ID A0A3Q2VTP7_HAPBU Unreviewed; 1071 AA.
AC A0A3Q2VTP7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIK5 {ECO:0000313|Ensembl:ENSHBUP00000015758.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000015758.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000015758.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR RefSeq; XP_005925199.1; XM_005925137.2.
DR AlphaFoldDB; A0A3Q2VTP7; -.
DR STRING; 8153.ENSHBUP00000015758; -.
DR Ensembl; ENSHBUT00000033927.1; ENSHBUP00000015758.1; ENSHBUG00000017741.1.
DR GeneID; 102310534; -.
DR CTD; 2901; -.
DR GeneTree; ENSGT00940000158852; -.
DR OrthoDB; 511851at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd06394; PBP1_iGluR_Kainate_KA1_2; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF351; GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Signal {ECO:0000256|RuleBase:RU367118};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT CHAIN 28..1071
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT /id="PRO_5027149523"
FT TRANSMEM 555..575
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 634..655
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 814..838
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 426..795
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 436..500
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 925..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 996..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1028
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1071 AA; 118847 MW; B63BB527194C37B8 CRC64;
MPALPALLLS IHFLSFLLVT MPPRSLSQAP LLSSVRMAAI LDDQSVCGRG ERLALALARE
NINSVMEGPA RARVEVDIYE LQKDSQYDTT DTMCQILPKG VVSVIGPASS PASGSTVSHI
CGEKEIPHVK IGPEETPRLP YLRFASVTLY PSNEDLSLAI GAILRSFSYP SASLVCAKAE
CLLRLEELVR RFLISRETLS VRMLDDNLDP TPLLKEIRDD KVATIIIDAN ASVSYLILKK
ASELGMTSAF YKYILTTMDF PLLRLDDIVD EQSNIVGFSM FNTTHPFYLE FIRSLNLSWR
EGCDLTYPGP ALSSALMFDA VHVVVGAVRE LNRSQEIGVK PLSCTSPQIW QHGTSLMNYL
RMVEYDGLTG RVEFNSKGQR TNYTLRILEK HRGGHKEIGI WYSNNTLAMN STSLDINVSE
TLANKTLIVT TILENPYVMR KDNYQDFQGN DQYEGFCVDM LRELADILKF SFKIKLVDDG
LYGAPEPNGS WTGMVGELIN RKADLAVAGF TITSEREKVI DFSKPFMTLG ISILYRVQLG
RKPGYFSFLD PFSPAVWLFM LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ERRDMLENQY
TLGNSLWFPV GGFMQQGSEI MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV
PIESPDDLAD QTNIEYGTIH GGSTMTFFMN SRYQTYQRMW NYMNSKQPSV FVKSTEEGIA
RVVNSKYAFL MESTMNEYHR GLNCNLTQIG GLLDTKGYGI GMPLGSPFRD EITLAILQLQ
ENNRLEILKR RWWEGGQCPK EEDHRAKGLG MENIGGIFVV LICGLIIAVF VAIMEFVWST
RRSAETDEVC PHTCPRRPHR HTPVSVCQEM ITEFRNAVSC KKSSRMRRRR PLSSSAALRH
PTRIALGAPR PLRLVREMRL SNGKLYSGAG PLTGGAGGGA GGTGQPDLGP GPQRILDDPL
GANTTPPPPA PTPVMLPARS CTHVRICQEC RRIQSLRSGS SIGSASTRIP PSSAPLPRIP
PPPPPSSSNT DSEGGGVPSP RRLHHSPPAH TPRPIPPPQS SNTSDLLGDQ D
//