ID A0A3Q2VV35_HAPBU Unreviewed; 1169 AA.
AC A0A3Q2VV35;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Tyrosine-protein phosphatase non-receptor type {ECO:0000256|PIRNR:PIRNR000934};
DE EC=3.1.3.48 {ECO:0000256|PIRNR:PIRNR000934};
GN Name=PTPN21 {ECO:0000313|Ensembl:ENSHBUP00000015866.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000015866.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000015866.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|PIRNR:PIRNR000934};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR000934}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649,
CC ECO:0000256|PIRNR:PIRNR000934}.
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DR AlphaFoldDB; A0A3Q2VV35; -.
DR Ensembl; ENSHBUT00000033982.1; ENSHBUP00000015866.1; ENSHBUG00000017930.1.
DR GeneTree; ENSGT00940000155613; -.
DR OMA; TEWDYIA; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13188; FERM_C_PTPN14_PTPN21; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR014392; PTP_non-rcpt_14/21.
DR InterPro; IPR041782; PTPN14/21_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF3; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 21; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PIRSF; PIRSF000934; Tyr-Ptase_nr14; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR000934};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR000934}; Hydrolase {ECO:0000256|PIRNR:PIRNR000934};
KW Protein phosphatase {ECO:0000256|PIRNR:PIRNR000934};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 23..305
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 893..1162
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1073..1153
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 312..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1103
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
SQ SEQUENCE 1169 AA; 133399 MW; 17D0C9FA79D64019 CRC64;
MPLPFGLKLK RTRRYTVSSK SCLVTRIQLL NGEFVEFTLS VESTGQECLE AVAQRLELRE
ITYFSLWYLN KQNQQRWIDL EKPLKKQLDK YGLEPTVYFG VVFYIPSVTQ LQQEITRYQY
YLQLKKDVLE GRISCSLEQA IRLASLAVQA DFGDFNRYDS QEFLQKFELF PIDWIQDERV
LEEAIQKVAL LYQGLPVPEA EMLYMQEVEK MEGYGQETFQ AKDNTGADVT LGSCLDGIFV
KHKSERPLVL YRWHDINNMS HNRSFFALEL ANREESVQYQ TEDMETSKYV CRMCLARLKF
YKINMSSLQP QPTVVNPVRR RSSTRVSLPK PQTYMMPPPQ MHYNGHFTEP YTSSQDNLYM
NSQNGFYYHS QTSLDCSPLE YSSGGRLRNG SVYSAHSTSS LTNPQHYLQP SPMSSNPSIT
SDITRPDYVP SHRHSALIPP SYRATPDYES VMRQKNRGAG GGMVLSQEHR QSHSMRNLNI
GNSYAYSRPD PLVYSQPEIR GEHGGAAQHH HYPLHLGSSF HSPSPYPYPT ERRSVVGAVS
VPELTNVQLQ QAQEYPAPNI MKTHVYRSPP PYPYAHPRPA NSTPDLSRHL YVSSSNPDLI
ITRRVHHSVQ TFQEDSLPVA HSLQEVSEPL YSGPPQRQQY HAQKRNSIEI AGLAQSFEGI
RVKERTASSS AAEMATPPPV LHGGRSQGSQ LNVFLEQKNP EDIEDIKEDV QYGHKKSLSD
ATMLVHSSGE EEDFEDDSGR HTPLSQEPPP AYPIGSSLDP SITGTLTYKV HTLIHEREPL
YLVSELQQPR IMPSVSEGDL SGQEKPRPKK DFKKRPVSDV PPGKKAVEGL PPAGMKKGAK
SEVKKMGPLK VAHLNGLSIS RQPVHSEIKD EPERASNDER CKVLEQHMEK GEVLKEYESI
PKRPRGEYTI AQLPESGDRN RFQDVLPYDD TRVELVPTKE NNTGYINASH IRVSLGGQEW
NYIASQGPMS HTCQDFWQMV WEQGVSIIAM VTAEEESGRE KSFRYWPRLG SRHNTVTYGR
FKITTRFRTE SGCYATTGLK IKHLLTQQER TVWHLQYTDW PDHGCPEDFK GFLTYLEEIQ
SVRRHTNSIS DPKNSNQPVL VHCSAGVGRT GVVILSEIMI ACLEHNEPLD VPKHLLALRN
QRMLMVQTLS QYTFVYRVLI QYLRNSRLI
//
