ID A0A3Q2VVI6_HAPBU Unreviewed; 592 AA.
AC A0A3Q2VVI6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Interleukin 1 receptor accessory protein {ECO:0000313|Ensembl:ENSHBUP00000015800.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000015800.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000015800.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
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DR AlphaFoldDB; A0A3Q2VVI6; -.
DR Ensembl; ENSHBUT00000024159.1; ENSHBUP00000015800.1; ENSHBUG00000017775.1.
DR GeneTree; ENSGT01090000260076; -.
DR OMA; YICTVRY; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890:SF20; INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN; 1.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00409; IG; 3.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..592
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018661299"
FT TRANSMEM 372..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..130
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 147..239
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 252..362
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 411..555
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 592 AA; 67837 MW; 0CF09DC188CB258D CRC64;
RATFISALVF LLAVMGGTSP AASQSSAPTE PMCYDWGESS EGAVSVVEGE VGWLSCPLFS
HPSVYNYTST QSAGHNLFWY RLPEGHDLEQ PIISRLSKDR ERLFLQPAAA ADTGQYICML
RNKSSCSKIA IRLKVLRPDD VVKCALPVAV APIEDLIPLQ EGKTLDCPDL QDATKMSESA
PKVQWYFVCD WYPFWDSDRE QKGNSLQVHL MMEQYQGLYY CRVQYQRRNQ TLNFTRSINV
TAILPLSLPK EPSIMNPTHD QIFTVKTGTE VRLVCRGQLP FVLDKPWREI WWTVDGKTLD
KLPDRFTQIN RVVRDHFRDL TIENILVIQD FQSKDLKREF YCSVKNERGF DTRRAQLEEE
VSLPTLELGC GLGVTLLLML ILFVVYHVFW LELLLLYRSW FGTDERHTDD KEFDVYISYA
RNSEEEQFVL LTLRRVLENE LGYSVCIFDR DSLPGGTITD ETLSFVARSR RLLVVVSPGY
ASQGSQALLE LKAGIDTMAL AGHLRVILVQ YKPVRRKGWV RELRRARVAL ALVRWQGDKS
RELSSRFWKR LRVELPVRRD MKKSTAMLAA LSVFTPENIS HQQANVFISV AL
//
