ID   A0A3Q2VWT8_HAPBU        Unreviewed;      1285 AA.
AC   A0A3Q2VWT8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Cell migration inducing hyaluronidase 1 {ECO:0000313|Ensembl:ENSHBUP00000016300.1};
GN   Name=CEMIP {ECO:0000313|Ensembl:ENSHBUP00000016300.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000016300.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000016300.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CEMIP family.
CC       {ECO:0000256|ARBA:ARBA00007586}.
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DR   Ensembl; ENSHBUT00000024782.1; ENSHBUP00000016300.1; ENSHBUG00000018354.1.
DR   GeneTree; ENSGT00940000153636; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-EC.
DR   CDD; cd13938; PANDER_like_TMEM2; 1.
DR   InterPro; IPR019316; G8_domain.
DR   InterPro; IPR039477; ILEI/PANDER_dom.
DR   InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR   InterPro; IPR039473; TMEM2_PANDER-like.
DR   InterPro; IPR025155; WxxW_domain.
DR   PANTHER; PTHR15535:SF15; CELL MIGRATION-INDUCING AND HYALURONAN-BINDING PROTEIN; 1.
DR   PANTHER; PTHR15535; TRANSMEMBRANE PROTEIN 2-RELATED; 1.
DR   Pfam; PF10162; G8; 1.
DR   Pfam; PF15711; ILEI; 2.
DR   Pfam; PF13330; Mucin2_WxxW; 2.
DR   SMART; SM01225; G8; 1.
DR   SUPFAM; SSF51126; Pectin lyase-like; 1.
DR   PROSITE; PS51484; G8; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lectin {ECO:0000256|ARBA:ARBA00022734};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          12..130
FT                   /note="G8"
FT                   /evidence="ECO:0000259|PROSITE:PS51484"
SQ   SEQUENCE   1285 AA;  143784 MW;  81C6019409BD73D3 CRC64;
     TYICPDKEPG LQPWMPGHSE DHRVTISNNR TVLLTTSATV HSIEILSGGK LVIADTNRPI
     LLRTKHILIG NKGELHIGSP DCPYKGNLTI LLFGSDEEHS YFGRKYIGVG SGGTLEIHGE
     RKLSWTFLNK TLHPRESSQN SYLFQRSWGN RGIIIHVIDP KTGEVLHDDR FDTYRSKNES
     YRLAKYVDGI KPGLILAMMV NDEGSNNLED SAKKSISRLG SKHIGSLGFR HPWTFIVTKG
     DVSSVVEDTA VYQEAEWSNW FDRDDERGSG DWEKLSDLHK AYPDRLCSSP LDIQAETHDG
     IPSNQTGDVI HKKHKDYGFV CLNKDQTHGL CHNYRVRFLC GKLVRPQASV SIDTMSNSSI
     LELADHPAGW GPGDRVVVAS TDYSMHQAEE FTLLPCPTCA SNQLKVRGKA KFIHMGEEVD
     GVDMRAEVGL LSRNILLRGE MEPSCYGNEA CKFFNFDTFG GHLKVEHGFR AVHISGMELQ
     HMGQQTMGHY PVHFHMNGDV DERGGYDPPT SVSDLSIHHS FSRCVTIHGS NGLMVKDVVG
     YDTLGHCFFT EDGPEERNTF EHCLGLMVRA GTLLPSDRDS KMCRDITDGA YPGYVPNPRQ
     DCSATSTFWI ANPNNNLINC AAAGSEETGF WFIFHHNATG PSNGSYSPGY TEHTPMGQFT
     NNRAHSNFRA GMILDNGVKT TQANNKDKRP FLSLIGARYG PHQDSDPFKP RVPALIHHFT
     AYKNQYHGAW LRGGDVWLDD CQFADNGIGL TLASGGTFPD DDGSHQQVKN SLFVGESDNH
     GMPFPDKRIW GPGGPDLTDR TLPRGIDFPI RGMQIYDGPI NVQNCTFRKY TALNGRHTSA
     FGFRLNNSWQ SCPNNNVTSI TFDHVPITSR VFFGEPGPWF SKMQMDGDKT TIFHDIDGSV
     SEYPGAFLVK EDNWLLRHPD CIDVPDWKGA ICSGHYAQVG QQSSQTQMDE YPDRPLTLEG
     ALEKRKHYQQ FQPVVTLAKG YTIHWDQAAP AEVTIWLINF NKNDWINVGL CYPQGTTFTI
     LSDIHNRLTK QTRKTGVFVR TTHKKKINHL HLARGYFYWE EDTGLLFLKV KAHNHRETFA
     FCSVKGCERV KIKAIVPKGS PPSNCLAKAY PKHAELPIVD VPMPRKIPTA RLVSNEIKMI
     PTPHYFPVEL ALFMSLEVNG KTLHQPEDGV HLTVIDGHDG KVVDTKGFRN SILQGIPAEI
     DNYISGLRDN SIVLMTSKGR LVTRGSWTKV LGKLGAEKSV SLKDKLAFVG FKGSFHPDWV
     YLEADSERAK IHQVLPIPVI HKMKL
//