ID   A0A3Q2VWV8_HAPBU        Unreviewed;       883 AA.
AC   A0A3Q2VWV8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000017088.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000017088.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC       {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR002291}.
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DR   AlphaFoldDB; A0A3Q2VWV8; -.
DR   Ensembl; ENSHBUT00000025779.1; ENSHBUP00000017088.1; ENSHBUG00000019245.1.
DR   GeneTree; ENSGT00940000155206; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 2.60.40.1150; -; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.30.310.10; TATA-Binding Protein; 1.
DR   InterPro; IPR026739; AP_beta.
DR   InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR015151; B-adaptin_app_sub_C.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR   InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR   InterPro; IPR013037; Clathrin_b-adaptin_app_Ig-like.
DR   InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR11134; ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER; 1.
DR   PANTHER; PTHR11134:SF9; AP-2 COMPLEX SUBUNIT BETA; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   Pfam; PF02883; Alpha_adaptinC2; 1.
DR   Pfam; PF09066; B2-adapt-app_C; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 2.
DR   SMART; SM00809; Alpha_adaptinC2; 1.
DR   SMART; SM01020; B2-adapt-app_C; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR   SUPFAM; SSF55711; Subdomain of clathrin and coatomer appendage domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002291};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR002291};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR002291}.
FT   DOMAIN          653..763
FT                   /note="Clathrin adaptor alpha/beta/gamma-adaptin appendage
FT                   Ig-like subdomain"
FT                   /evidence="ECO:0000259|SMART:SM00809"
FT   DOMAIN          772..882
FT                   /note="Beta-adaptin appendage C-terminal subdomain"
FT                   /evidence="ECO:0000259|SMART:SM01020"
FT   REGION          551..571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   883 AA;  98804 MW;  EE4A51DFFD648E54 CRC64;
     MTDSKYFTTN KKGEIFELKA ELNNEKKEKR KEAVKKVIAA MTVGKDVRYT FSDVSCTQDC
     EDPNPLIRAL AVRTMGCIRV DKITEYLCEP LRKCLKDEDP YVRKTAAVCV AKLHDINAQM
     VEDQGLSTLH LYLYLSQKIS ESHPNSNLLD LNPQNINKLL TALNECTEWG QTFILDCLSN
     YNPKDEREAQ SICERVTPRL SHANSAVVLS AVKVLMKFLE LLPKDSDYYN TLLKKLSPPL
     VTLLSGEPEV QYVALRNINL IVQKRPEILK QEIKVFFVKY NDPIYVKLEK LDIMIRLASQ
     ANIAQVLAEL KEYATEVDVD FVRKAVRAIG RCAIKVEQSA ERCVSTLLDL IQTKVNYVVQ
     EAIVVIRDIF RKYPNKYESI IATLCENLDS LDEPDARAAM IWIVGEYAER IDNADELLES
     FLEGFHDEST QVQLTLLTAI VKLFLKKPSE TQELVQQVLS LATQDSDNPD LRDRGYIYWR
     LLSTDPVTAK EVVLSEKPLI SEETDLIEPT LLDELICHIG SLASVYHKPP SAFVEGSHGI
     HRKHLPVQHS SIDTGESPVS GGPAAAMDQP HVIPSQGDLL GDLLNLDLGP PVNVPQVSSM
     QMGAVDLLGG GLDSLVIPNT FAPSPTPAPP ATSSGLNDLF ELSTGMAITT GGYAVPKAVW
     LPAVKAKGLE ISGTFSRRQG HMYMDMTFTN KALQHMTDFA IQFNKNSFGV IPTSPLPVHT
     PLMPNQSIEV SLPLNTIGPV MKMDPLNNLQ VAVKNSIDVF YFSVLIPLNV FFVEDGKMER
     QVFLATWKDI PNENELQYQI KDCHLNADTV SGKLQNNNIY TIAKRNVEGQ DMLYQSLKLT
     NGIWILAELR IQPGNPNYTL SLKCRAPEVS QYVYQMYDSV LKN
//