ID   A0A3Q2VXM0_HAPBU        Unreviewed;       836 AA.
AC   A0A3Q2VXM0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000017413.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000017413.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q2VXM0; -.
DR   STRING; 8153.ENSHBUP00000017413; -.
DR   Ensembl; ENSHBUT00000026187.1; ENSHBUP00000017413.1; ENSHBUG00000019454.1.
DR   GeneTree; ENSGT01100000263513; -.
DR   OMA; KSPNCKM; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029495; NACHT-assoc.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF14484; FISNA; 1.
DR   Pfam; PF13516; LRR_6; 3.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   SMART; SM01288; FISNA; 1.
DR   SMART; SM00368; LRR_RI; 5.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS51450; LRR; 2.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        806..830
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          152..286
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
SQ   SEQUENCE   836 AA;  94712 MW;  BA3EB843DD815CC0 CRC64;
     VSQQTETDLD STFMVCTCAT TTFTSILFST SMLLFVDQWI VSVSNMDLME RHIFKGNALE
     NKTVIFCPRK LKSKLKKKFQ CVFEVVAKAG NPTLLNQIHT ELYFTEGGTA EVNDEHEVRQ
     IETASRKPDR PEKTIRREDI FKASPGRDEP IRTVLTKGVT GIGKTILIQK FSLDWAEGKA
     NQDIQFIFPF TFRELNVLKE KRFSLVELVH HFFTETKEAG ICSFEDFQVV FIFDGLDECR
     LPLDFHKNEI LTDPRKPTSV DVLLTNLIRG KLLPSARIWI TTHPAAANHI PPQCVDMVTE
     IRGFTDPQME EYFRKRFRDE EKGSRIISHI KTSQSLYIMC HIPVFCWITA TVLEDVLETR
     EGRQLPKSLT EMYIHFLVVQ AKVKKVKYDG GAETDPHWSP ESRRMIESLG KLAFDQLQKG
     NLIFYESDLI ECGIDIIAAS VYSGVFTQIF REERGLYQEK VFCFIHLSVQ EFLAALYVHL
     TFINSGVNVL EEQQTTSQKF KRSQSFDMLI FFQSAVDKAI QSPNGHLDLF LRFFLGLSLQ
     TNQTLLRGLL TQTGSSSQTN QETVQYIKEK LSENLSAEKS INLFHCLNEL NDRSLVEEIQ
     QSLRSGSFST DELSPSQWSA LVFVLLSSEK DLDVFDLKKF SASEEPLLSS QYCKLRELDL
     SNNNLQDLGV KLPNCKLEIL RLSSCFLSER SGYAISSVLS SQASRLRELD LSNNNIQDSG
     VKLLSAGLKS PHCKLATLRL SACNLSQRSC EALSSALSSQ SSSLRELDLS ENDIEDAGVK
     LLSVTLNSTH CILETLRSGF SLCHSALFRI CIALLNICLK VIVLTGAFYI PLVRLF
//