ID A0A3Q2W0E1_HAPBU Unreviewed; 1009 AA.
AC A0A3Q2W0E1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN Name=MAN2B2 {ECO:0000313|Ensembl:ENSHBUP00000018021.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000018021.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000018021.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR RefSeq; XP_005925907.1; XM_005925845.2.
DR AlphaFoldDB; A0A3Q2W0E1; -.
DR STRING; 8153.ENSHBUP00000018021; -.
DR Ensembl; ENSHBUT00000026936.1; ENSHBUP00000018021.1; ENSHBUG00000020161.1.
DR GeneID; 102308899; -.
DR CTD; 23324; -.
DR GeneTree; ENSGT01030000234638; -.
DR OMA; LWMILGS; -.
DR OrthoDB; 5474711at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10811; GH38N_AMII_Epman_like; 1.
DR Gene3D; 2.60.40.1360; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF28; EPIDIDYMIS-SPECIFIC ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Signal {ECO:0000256|RuleBase:RU361199};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT CHAIN 22..1009
FT /note="Alpha-mannosidase"
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT /id="PRO_5018377859"
FT DOMAIN 355..438
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1009 AA; 115784 MW; 4F8E1E3F2742B6E9 CRC64;
MGFVAAVVFA VCCWFSHGVA GQEEPIQTFV IPHSHMDVGW VYTIQESMHA YAANVYSSVT
EELSKVKERR FIAVEQEFFR LWWDTVASVT QKKQVRQLIK EGRLEFIIGG QVMHDEAVTD
LDDDILQMME GHGFLYETFG VRPQFSWHVD PFGASATTPV LFALAGFNAH LISRIDYDLK
DTMQKNKKLQ FVWRGSPSLK SQQEIFTHTM DQFSYCTPSY LPFSNRSGFY WNGVALFPDP
PKDGIYPNMS LPVIKETVHA YAKTMVENIK QRAAWFRTHH VLWPWGCDKQ FYNSSVQFNN
MDPLMKYINQ NSKEFGVTVQ YATLSEYFQA IYQSNLTWEV RGSEDFLPYS TEPYQAWTGF
YASRNVLKGV ARQASSKLYA AETLFARYRI SFPDGPVAKD WALDKLRALR WAVSEVQHHD
GITGTESPKV ADMYLQHLLQ AMMGAEELLA ALFLLPHNLM SPSTLGERYP TKADVDQALE
QHVIVYNPLA WNITTIVNVT VTQPSAAVFD DDGQPVPAQI QGSAHSNATY DLFIVVELGG
LQYRKYLIKF PENSKAYEAK AASFERRGVK DRAKAGRRLL PVLSECYELL FDQDTNLLHS
ITYLEEKRRV MITQDFWEYD ANGDVKAGPI SDNYIFSANG SAVRAYKAVE MEIIPGKIVT
EIRQYFYREE SDKDYAYSIT TRVPECFGTK LPCHRLEQTY SLGPLSLNTE VVLRTSTSVK
NNRTLYSDDN GYQMMKRTYR KFTNNTLARN YFPMVRTAYI EDDLSRLVLV SDRAHGVSSQ
TDGQLEVMLH RRLWNNLQWN LGYNLTLNDS SVVRPTLWMM LGSVSATSKL YQREAVQLQH
RPVVMPIDQP QKPWQVKEPK RGSPLRSVVL PPNLHLLSLS VPGWNYCSNH SVHLSHIQSG
KDLHSQPDYD RILLRIMHLF EEGEDPELSK PVTINLKEAL QGMGEVKGVE ERSLTGTWDV
ASLQRWKWKT ADNLENDNKQ QRTRDDNFTV TISPKEIRTF FVHFVSRNF
//
