ID A0A3Q2W0E3_HAPBU Unreviewed; 618 AA.
AC A0A3Q2W0E3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Mitogen-activated protein kinase kinase kinase 3-like {ECO:0000313|Ensembl:ENSHBUP00000014408.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000014408.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000014408.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005912371.1; XM_005912309.2.
DR AlphaFoldDB; A0A3Q2W0E3; -.
DR STRING; 8153.ENSHBUP00000014408; -.
DR Ensembl; ENSHBUT00000033366.1; ENSHBUP00000014408.1; ENSHBUG00000016292.1.
DR GeneID; 102293509; -.
DR CTD; 100126011; -.
DR GeneTree; ENSGT00940000164858; -.
DR OMA; PRSYIPQ; -.
DR OrthoDB; 145974at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06653; STKc_MEKK3_like_u1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR48016; MAP KINASE KINASE KINASE SSK2-RELATED-RELATED; 1.
DR PANTHER; PTHR48016:SF50; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT DOMAIN 354..614
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 383
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 618 AA; 69742 MW; 07A5A614D2E85F8F CRC64;
MMTVNMDDGL QNGSGQHRNS QDDEEALNSI MKDLAALGRC YTQHNSHKPK NRTLLYKQDL
RVKLEHEREK RIILFQRPLK IKELLQKVTE AFGQQMDMFF MEKELLLPLK TQEDLDQAVL
TLGCSSGANG LLRILLKTPK NNHYLQVNSR DKQSEMKSSR SLGDLKGSLL KGSERVRKHS
TGSLHTGRTS PPPGSVPEEQ QQIARQGSYT SIHSEGEFIP ENPDQSMLDP FGSADNSLSS
SCQSIDQALD SPPYSQNTRD NNYLNLNFEY KGRHGKGGTF PRQFQLPNRS KDYGDRRRTL
PRSFMPQENL FQLVPSSRTR SYNGDSTLQY SDLRSLGKSS QRGTAKSPRA PVNWRQGKLL
GRGAFGEVYL CYDADTGREL AAKQVPFDPD CQETSKEVNA LECEIQLLKN LRHERIVQYY
GCLRDLDQRK LTIFVEFMPG GSIKDQLKAY GALTEKVTKR YTRQILQGVS YLHSNMIVHR
DIKGANILRD SSGNVKLGDF GASKRIQTIC MSGTGIKSVT GTPYWMSPEV INGEGYGRKA
DVWSVACTVV EMLTQKPPWA EYEAMAAIFK IATQPTKPTL PEGVSDACRD FLRQVFVEEK
WRPTADFLLS HPFVQGSF
//
