ID   A0A3Q2W0S8_HAPBU        Unreviewed;      2028 AA.
AC   A0A3Q2W0S8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Ral GTPase activating protein catalytic subunit alpha 2 {ECO:0000313|Ensembl:ENSHBUP00000017945.1};
GN   Name=RALGAPA2 {ECO:0000313|Ensembl:ENSHBUP00000017945.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000017945.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000017945.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_014189070.1; XM_014333584.1.
DR   Ensembl; ENSHBUT00000026846.1; ENSHBUP00000017945.1; ENSHBUG00000020011.1.
DR   GeneID; 102304850; -.
DR   CTD; 57186; -.
DR   GeneTree; ENSGT00950000183139; -.
DR   OrthoDB; 21929at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   InterPro; IPR046859; RGPA/RALGAPB_N.
DR   InterPro; IPR027107; Tuberin/Ral-act_asu.
DR   PANTHER; PTHR10063:SF2; RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-2; 1.
DR   PANTHER; PTHR10063; TUBERIN; 1.
DR   Pfam; PF20412; RALGAPB_N; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT   DOMAIN          1770..1978
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          341..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          711..753
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          811..911
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1615..1634
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1689..1716
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        364..381
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        821..858
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        869..888
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2028 AA;  228270 MW;  63BF3CD989F238B2 CRC64;
     MFTRRGHGDV KKSTQKVLDP KKDVFTRFKH LRTLLDIIDK SELKTFFESN SSQIYFIFYE
     NFITLESNLK QKGNKSQREE LDSILFIFEK ILQNLPEKIY NRWQFHSIGS ILKKLLHTGN
     SFKIRCEGIR LFLLWLQALR DHCAEEQFLI FACLVPGFPA VPSSRGPCTL DTIIYNPFSN
     PPDAKVVPEE ITPLVPAVAG EKAADDLTCF ILEILLKYMV IQASSLEWKN KENQDTGFRF
     LFTLFKKYYL PHLFPSFTKL TNLYKPLLDL PHHRPKPLYV PVTRNNESTF CTRDQYLAPR
     VAFITWLVTF FLEKKYISSA ASAQSAKNGT EVIPKLIQTV TAGSSSQEKD KTSDGDANGP
     AGEPEKSHSN SSTLSDRRAS DSSLCSVEEE HRHVYDMVQS ILLSTRDNVN FVNEIFHQAF
     LLPSCEASAT RKVIKVYRKW LLQEKPSFMA EPDRTAREDE VDECSEQIIS TETNNMHVQM
     MESHSHKRSS SWGRTYSFSS AINQGFITEE ENRNIKAGIQ PTLQVFLTSS SNVFLLEPCQ
     DVPKLLENQV EVCKGVLSIY RHMIMEHSMN TQTWEQMLQV LLRITEAVMK RPQDNQRKDS
     FAESLASLLF RTIIVAWVRA NLCVFISREL WDELLAVLSS LTCWEELVTE WASIMDSLTA
     VLARSVYGLD MANLPLDKLS EQKEKKQRGR GVIQDSQKAA AVARSFSLSW RNHGEQGGPP
     VQEPMRTRSA TTSGAPGVEK ARNNVRQKAS AKRSQSISNC VHLYEALPTT KSVPMLLHTV
     SSFLPGISSG NSACSHRLSD VEECQLSECG GEEELGGRDS PLPRSSSTSD ITQQLSETLP
     VQQREYSPTS CGSDSRMSEG RTESSEPPVI LIRRTSSSAE TECNTEGHAN YTRPKLREKS
     ESVSSETSNG YLNEAEVTWQ TFDEEADNQS TQSAHMDVTV DPQSQGSLLL SHNEALAGPE
     CALPTHSASP SYHHNHQNHY HYPQNPPASP ALLVHTECPR DCPLDDTMHQ SVLHMPHHLD
     SSEFLADDVS IIAGGTLTGW HADSAFVLWR RILGILGDVN NIRCPKIHAK VFSYLYELWH
     KLAKIRDNLG ISVDNQSSPP QPAFIPPLRM LASWLFRATM LPAEYKAGKL QAFKLICEMM
     TRHQDVLPNS DFLVHLYHIM HKGFMSDDPD VLNTIIRSCS PRFFFLGLPG FTMLIGDFIA
     AAACVLTSGS SEAPRVEAQT ILGSLVCFPN LYLQIPILHR VPGSDDISVS NEDIKNYLVN
     ILLETATKEH YEGARCIAVC SLGLWVCEEL MQKNIHPQVK DAINVLGVTL KFGNKAVAQV
     ACDVFQLLIS HWEHLQRLEP TFPKKIIEIF VATIAFLLPS AEHSTVEADK KLMVSLLLCL
     LDWCMAVPLS LLLEPITMPS LEDHTAHKAP LLDYIYRVLH CCVAGSNLHT QQSHYLLTLS
     DLSSDYDLML GQVKRCEPPP SQTPTMDLGN LLTVAEEKRR RNMELIPLTA RMVMTHLVNH
     LGHHPLSGGP ALLHSLVSEN HDNPYVESSE LSSEVFKSPN LQLFVFNDST LVSYLQIPAE
     TPTVGESLHT SSQVRVIVRD ISGKYSWDGA ILYCTAHEDF DVGAFKPVDP SLSAATAVSH
     SSNPPPSPVA GPHKRHCSGS DCLSNSCEED EFDVLDKLLE DLGHSSPECL PQPRLKLNQP
     AASPHGMNLE QENAILEAIH RQTQQEEEQV RRWEADVSFR ADCQSEPSHQ EPKAPFYFCR
     LLLNDLGMNS WDRRKSFHLL KKNSKLLREL KNLDSRQCRE THKIAVFYIG EGQEDKCSIL
     SNSTGSQDYE DFVSGLGWEV DLATHCGFMG GLQRNGSTGL TAPYYATSTV EVIFHVSTRM
     PSDSDDSLTK KLRHLGNDEV HIVWSEHTRD YRRGIIPTDF GDVLIVIYPM KKHMYFIQIM
     KKPQVPFFGP LFNGAIVTGM LLPSLVRATC INASRAVKSR LTLYQSFYEE RALYLEAIVQ
     NHREVMTFED FASQVFSPSP GYPMSGTACR RWPGMVWDME YPWAKLDY
//