ID A0A3Q2W1Y5_HAPBU Unreviewed; 845 AA.
AC A0A3Q2W1Y5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Follistatin like 4 {ECO:0000313|Ensembl:ENSHBUP00000019223.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000019223.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000019223.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_005923151.1; XM_005923089.2.
DR RefSeq; XP_005923152.1; XM_005923090.1.
DR AlphaFoldDB; A0A3Q2W1Y5; -.
DR STRING; 8153.ENSHBUP00000019223; -.
DR Ensembl; ENSHBUT00000028503.1; ENSHBUP00000019223.1; ENSHBUG00000021437.1.
DR GeneID; 102314445; -.
DR CTD; 23105; -.
DR GeneTree; ENSGT00940000158076; -.
DR OrthoDB; 3043918at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05736; IgI_2_Follistatin_like; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR10913; FOLLISTATIN-RELATED; 1.
DR PANTHER; PTHR10913:SF9; FOLLISTATIN-RELATED PROTEIN 4; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF07648; Kazal_2; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF75011; 3-carboxy-cis,cis-mucoante lactonizing enzyme; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..845
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018550252"
FT DOMAIN 94..141
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 179..214
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 257..327
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 345..430
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 25..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 845 AA; 94133 MW; DDBC7ABBBDBF9DD1 CRC64;
MGSMGVWAVA VAALLGTSGC WLAEGHKSSR RSSGDTVSVS RTSSQEPRAM EKGKADGNID
QSLSDLDGDP CRRTYCGRGR QCVLMAETGR AECVCQEKCR PSFVPVCGSD GRFYENHCEV
YRTACLERRR IYVVHSKDCF FKGNACTMSE YNKLKSMLLD MQPKALKAGE QNQKRDMEEK
RALVDTMFKY LDANQDGRLI SDELEKISMK EHLEDSLLEC TMQDLLRYDD YNNDGHLSLH
EFYTAFQVVQ LSLAEDQRIS VSTVTVGLSA VLTCAIQGTL RPPVIWKRNG IILNFLDLED
INDFGDDGSL YITKVTTIHM GNYSCHAYGY EDLYQTHVLQ VNVPPVILVY PETQAQEPGV
SASLHCHADG IPNPKLLWLK NGMDLQPRSS KQLSLIANGS ELFIGSVRYE DTGAYTCIAK
NEVGVDEDIS SLFVEDSAKK TLANILWREE GLSVGNMFYV FSDEGITLLQ PSECEIRRHL
KRTERIVATY EEMCPKGEGV SPQHCVWSSA VNIRDKYIYV TQPLQSRVLV VDIQAQKVVQ
AVTTDPFPVK MLYDKSHDQV WVLTWGDMDK THPTLQVIPQ ASVGEVHHAI RTTFQRVNDF
FIPPTNLIIT HVRFAFVFLK NEPAIHKIDL ETLHRVKTIS LKNNSCIPVS MAYTHLSGFY
FIQCQTKSLL APQQLLIDSV TDAVIGPNLN VTGQAFVSPD GRYIVTPDPQ SSKLIVQTVS
FQGELSLNQE IDEPVAVSDL VFQPSFTESN QHVAVATSGS GTDLLFADLS SGHTEVLRSL
KQPLAPQAWP WGGPNRVVVS SGLFGQYLVT PSAESLFVLN GKQRTPHCEV SDIKRGNTVV
WVGEV
//
