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Database: UniProt
Entry: A0A3Q2W2Q6_HAPBU
LinkDB: A0A3Q2W2Q6_HAPBU
Original site: A0A3Q2W2Q6_HAPBU 
ID   A0A3Q2W2Q6_HAPBU        Unreviewed;      2795 AA.
AC   A0A3Q2W2Q6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Neural-cadherin-like {ECO:0000313|Ensembl:ENSHBUP00000018725.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000018725.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000018725.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC       {ECO:0000256|RuleBase:RU004357}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003318};
CC       Single-pass type I membrane protein {ECO:0000256|RuleBase:RU003318}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   STRING; 8153.ENSHBUP00000018725; -.
DR   Ensembl; ENSHBUT00000027881.1; ENSHBUP00000018725.1; ENSHBUG00000021000.1.
DR   GeneTree; ENSGT00940000164020; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0060429; P:epithelium development; IEA:UniProt.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 15.
DR   CDD; cd00054; EGF_CA; 3.
DR   CDD; cd00110; LamG; 2.
DR   Gene3D; 2.60.120.200; -; 2.
DR   Gene3D; 2.60.40.60; Cadherins; 15.
DR   Gene3D; 2.10.25.10; Laminin; 3.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR000233; Cadherin_Y-type_LIR.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR001791; Laminin_G.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   PANTHER; PTHR24027:SF438; CADHERIN-RELATED 23; 1.
DR   Pfam; PF01049; CADH_Y-type_LIR; 1.
DR   Pfam; PF00028; Cadherin; 12.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF02210; Laminin_G_2; 2.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 14.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00179; EGF_CA; 4.
DR   SMART; SM00282; LamG; 2.
DR   SUPFAM; SSF49313; Cadherin-like; 16.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR   SUPFAM; SSF57196; EGF/Laminin; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00232; CADHERIN_1; 6.
DR   PROSITE; PS50268; CADHERIN_2; 15.
DR   PROSITE; PS00022; EGF_1; 3.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 3.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003318};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003318};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          224..298
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          318..416
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          417..517
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          527..619
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          620..726
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          730..835
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          836..935
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          936..1047
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1048..1162
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1163..1264
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1265..1371
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1380..1491
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1492..1599
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1609..1705
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1705..1826
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          2068..2107
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2108..2303
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          2306..2345
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2348..2510
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          2553..2589
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REGION          2723..2773
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2729..2756
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        2097..2106
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        2335..2344
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        2557..2567
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        2579..2588
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   2795 AA;  307349 MW;  87B8F732C8B3AA7D CRC64;
     MQRKLIFLPV ISELHLESRS LCGCVQFAAS GGLVMIWVVV LPFFISCAFG NRTVEQVPFF
     HGHVFENSSP GCRVNGLSVP LKRLNSQRLC GAGEPSSAAA HLKLLGEGSE NFRVFAHHKR
     GHILLKTSRV LDREERAEYA LGLGLCCGQC AGLSREEEDI LDDATALNGS FYVVPKTGDI
     LLVDSILGLD EPIKFEVFAR DRGWPPRTSQ GITVEINPRS VLESDSPVLI NVSEDAGIGS
     VVMNLNPVRF QSATFELVEP DVESSPVSVS RDTGDIIITR KLDRETEPLV EITVRVQDKR
     GGVHPGQVTS LSQEWSMVPA PYLAVVSPDA SAGSLVYKLF AEDGDEGNNG EVEYFLSDGG
     DGRFEVDRKT GQVRTTGLPL QRDREYLLTV VAADRLGSRS APAVISVVAG PRPPQFTNAS
     FTIAIPENTP EGQPFLATPA VSFQKKPISY SLLINPSSLF SISAETGEIS LTRPIDYESD
     QHRYLLLVRA SEGIESMSSA AEVRVVITDE NDCVPEFLQS IYSKDGVPET VTTATSLLQV
     SANDCDSEEN AELTYYTLSP DFTISPHGTI FPAGPLDYER PNHLYEFVVM AIDKGEVPRT
     GTTTVRIRMA NVNDEAPEFS QHIYRTFVSE DAGPNTLVAT VLAKDPDGDG ITYKITTGNE
     EGNFVIDNQK GLIRLRSSPP PRLQGVEYVL NVTATDDNAS GGPQALSSTA QVIVGVDDVN
     NNKPVFEKCQ QYRESTSVLE NQPAGTFVLQ VHAVDADEGS NGRVTYGFMH KDSTVPAFSI
     HPETGVIVTA RKFDRERQRE YAVTVTATDQ AADPLIGICQ LNILILDQND NSPKFENLRY
     EYFLREDTMI GTSFLRVAAH DDDFGTNAAI TYSMSNEQPE YLRVNPLTGW VYVNQPISQR
     TYITRDIVAT DGGNRSSSVE LAVTITNVKN QPPQWEKDNY NVVIPENTVR DTPIVTIKAT
     SPLGDPRVTY NLEDGMVPET NMPVRFYLTP NREDGSASIL VAEPLDYETT KNFMLRVRAQ
     NVAAVPLAAF TTVYVNVTDV NDNVPFFTSS IYEASVTEGA ESGALVFQVS ANDLDLGPNG
     KISYSLLEDR SGDHQYFRID PELGFIYTQA VFDRETKSSY LLEVQSVDGW ESARPGKHGQ
     PNSDTAYVRI FISDVNDNKP EFAQASYEVD VDEDADVGFA ILTVSANDGD EGGNAKLRYQ
     ITSGNTGGVF DVEPEVGTIF IAQPLDYEQN KRYKLHLLAS DGKWEDYTTV TVNVVNKNDE
     APVFTVNEYY GSVTEELDGS PVFVLQVTAT DPDKDADQEA LRYSLHGQGA DSEFIIDEVT
     GKIYAQRTLD REERAVWRFV VLATDEGGEG LTGFTDVIIN VWDINDNAPI FTCAPSCHGE
     VAENSAAGTS VMEMTATDLD DSAVGQNAVL SYRIVGSLDA TNAELGGVPT FSEMFTINPT
     TGTITVGIGG LDREQVESYL LVVEARDGGG MAGTGTATIL IKDVNDHAPR FTDHSCLARI
     SENAEPNAEV LDLAAEDRDI GENAQLTFSV VSGDQEQKFY MVSHKQEQRG TLRLKKRLDY
     ERHSEQRFNL TLKVEDLDFS SLLHCVVEVE DYNDHAPVFI PHFMSLAPLP EDIVVGTSVA
     HLVASDSDSG QNRDITYSLS EDSDPEGLFT IDQSGLLSVA RPLDRERIPQ HHLVVIATDH
     GVPALTGSAT VQLPLLDVND NGPEFEAAYS PIVFENVSGP QVVRLNQTST LLQAVDHDSP
     ENGPPFHFAV PPEYRYSNDF YLQDNLNGTA TLTALRTFDR ERQKEFLIPI IMSDSGSPAK
     TVTSTLTVTI GDQNDHAHVA GEKEIFINSH RGRMPTTVLG KVYSPDPDDW DNKTYVFEGH
     VPSYFILNKR TGFLIIKENA PPGTYQFQVR VSDGIWPDAV STVTVHVREL RDDAIYNSGS
     LRLADITAKE FIELRGKQRS RYELLVDFLS EMLSVPPDDV NIFSLMDVKE RMLDVRFAVH
     SGPSFLQPEK MHGYLAAHKQ KLQSFLQVSV FQVRVDECPS SECGGTGGCS NTLNVRDTPT
     VVDCGTMSLV SVTVESTAVC SCPGREQSHQ PCATYPRNPC YNGGVCVDTQ HGYRCQCPAQ
     FEGPECQQNK HSFHGNGYAW FPPMMPCFES HVSLEFITDV ADGLVLYSGP LAQLQAWDHE
     DFMAIELIDG TPTLKINHGS GTVVLQLPGN VNVADRRWHR LDVRSNSKVG LRFTLDRCSG
     AAVKELVGSW LTSQDHSSCE VMGVTHLNMS QVLQLGGVNE DIPYIYPQLQ HKHFTGCVRN
     LIVDSKLYDL GSPADSQSSS PGCLTTDSSC VNMGYPSCGH RGRCHGEWGS FSCQCIPGYT
     GHQCEEEVPE YSFDGHSHVR YQLASPLPAR RTWIQVLVRT RKHSSVLFSL ISKEQSEYLR
     LEVSGLLCVF YNLGDGDYNL TLPTYRLDNG EWHEVFLDRH DNEMTLRMDG GGGQREVSGL
     QGRSREIIID PTVVMLGNTF PSGINKSFQG RCQPRDGVSQ VSVQGLSVGC SSDSCKRNQC
     SPPFTCVDLW RVHECRCPPG HMISVNGTKK SCVYTLCAMR PCHRGTCVAQ SPSKFTCHCP
     EGYRGHRCET TLAIYREDVG LSFSSLFAIC ICFMALLGKS WLKEGVYHVS AHHDGWEDIR
     ENVLNYDEEG GGEEDQNAYD MAELQKSLQP SPAQSVLRRD VPPTRLPAQG QARPSQLARR
     SLSFSSQDLA RYLCEIIRDA DQHPDTGPFD SLQVFSTEGG GSPAGSLSSF SSAGLDGGSS
     GEGGVEARRE ETLGEWGPRF EKLRALYERA EASDL
//
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