ID A0A3Q2W2Q6_HAPBU Unreviewed; 2795 AA.
AC A0A3Q2W2Q6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Neural-cadherin-like {ECO:0000313|Ensembl:ENSHBUP00000018725.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000018725.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000018725.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003318};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU003318}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 8153.ENSHBUP00000018725; -.
DR Ensembl; ENSHBUT00000027881.1; ENSHBUP00000018725.1; ENSHBUG00000021000.1.
DR GeneTree; ENSGT00940000164020; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0060429; P:epithelium development; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 15.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.60.40.60; Cadherins; 15.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF438; CADHERIN-RELATED 23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 12.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF02210; Laminin_G_2; 2.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 14.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49313; Cadherin-like; 16.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 6.
DR PROSITE; PS50268; CADHERIN_2; 15.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 224..298
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 318..416
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 417..517
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 527..619
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 620..726
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 730..835
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 836..935
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 936..1047
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1048..1162
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1163..1264
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1265..1371
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1380..1491
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1492..1599
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1609..1705
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1705..1826
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2068..2107
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2108..2303
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2306..2345
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2348..2510
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2553..2589
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 2723..2773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2729..2756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 2097..2106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2335..2344
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2557..2567
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2579..2588
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2795 AA; 307349 MW; 87B8F732C8B3AA7D CRC64;
MQRKLIFLPV ISELHLESRS LCGCVQFAAS GGLVMIWVVV LPFFISCAFG NRTVEQVPFF
HGHVFENSSP GCRVNGLSVP LKRLNSQRLC GAGEPSSAAA HLKLLGEGSE NFRVFAHHKR
GHILLKTSRV LDREERAEYA LGLGLCCGQC AGLSREEEDI LDDATALNGS FYVVPKTGDI
LLVDSILGLD EPIKFEVFAR DRGWPPRTSQ GITVEINPRS VLESDSPVLI NVSEDAGIGS
VVMNLNPVRF QSATFELVEP DVESSPVSVS RDTGDIIITR KLDRETEPLV EITVRVQDKR
GGVHPGQVTS LSQEWSMVPA PYLAVVSPDA SAGSLVYKLF AEDGDEGNNG EVEYFLSDGG
DGRFEVDRKT GQVRTTGLPL QRDREYLLTV VAADRLGSRS APAVISVVAG PRPPQFTNAS
FTIAIPENTP EGQPFLATPA VSFQKKPISY SLLINPSSLF SISAETGEIS LTRPIDYESD
QHRYLLLVRA SEGIESMSSA AEVRVVITDE NDCVPEFLQS IYSKDGVPET VTTATSLLQV
SANDCDSEEN AELTYYTLSP DFTISPHGTI FPAGPLDYER PNHLYEFVVM AIDKGEVPRT
GTTTVRIRMA NVNDEAPEFS QHIYRTFVSE DAGPNTLVAT VLAKDPDGDG ITYKITTGNE
EGNFVIDNQK GLIRLRSSPP PRLQGVEYVL NVTATDDNAS GGPQALSSTA QVIVGVDDVN
NNKPVFEKCQ QYRESTSVLE NQPAGTFVLQ VHAVDADEGS NGRVTYGFMH KDSTVPAFSI
HPETGVIVTA RKFDRERQRE YAVTVTATDQ AADPLIGICQ LNILILDQND NSPKFENLRY
EYFLREDTMI GTSFLRVAAH DDDFGTNAAI TYSMSNEQPE YLRVNPLTGW VYVNQPISQR
TYITRDIVAT DGGNRSSSVE LAVTITNVKN QPPQWEKDNY NVVIPENTVR DTPIVTIKAT
SPLGDPRVTY NLEDGMVPET NMPVRFYLTP NREDGSASIL VAEPLDYETT KNFMLRVRAQ
NVAAVPLAAF TTVYVNVTDV NDNVPFFTSS IYEASVTEGA ESGALVFQVS ANDLDLGPNG
KISYSLLEDR SGDHQYFRID PELGFIYTQA VFDRETKSSY LLEVQSVDGW ESARPGKHGQ
PNSDTAYVRI FISDVNDNKP EFAQASYEVD VDEDADVGFA ILTVSANDGD EGGNAKLRYQ
ITSGNTGGVF DVEPEVGTIF IAQPLDYEQN KRYKLHLLAS DGKWEDYTTV TVNVVNKNDE
APVFTVNEYY GSVTEELDGS PVFVLQVTAT DPDKDADQEA LRYSLHGQGA DSEFIIDEVT
GKIYAQRTLD REERAVWRFV VLATDEGGEG LTGFTDVIIN VWDINDNAPI FTCAPSCHGE
VAENSAAGTS VMEMTATDLD DSAVGQNAVL SYRIVGSLDA TNAELGGVPT FSEMFTINPT
TGTITVGIGG LDREQVESYL LVVEARDGGG MAGTGTATIL IKDVNDHAPR FTDHSCLARI
SENAEPNAEV LDLAAEDRDI GENAQLTFSV VSGDQEQKFY MVSHKQEQRG TLRLKKRLDY
ERHSEQRFNL TLKVEDLDFS SLLHCVVEVE DYNDHAPVFI PHFMSLAPLP EDIVVGTSVA
HLVASDSDSG QNRDITYSLS EDSDPEGLFT IDQSGLLSVA RPLDRERIPQ HHLVVIATDH
GVPALTGSAT VQLPLLDVND NGPEFEAAYS PIVFENVSGP QVVRLNQTST LLQAVDHDSP
ENGPPFHFAV PPEYRYSNDF YLQDNLNGTA TLTALRTFDR ERQKEFLIPI IMSDSGSPAK
TVTSTLTVTI GDQNDHAHVA GEKEIFINSH RGRMPTTVLG KVYSPDPDDW DNKTYVFEGH
VPSYFILNKR TGFLIIKENA PPGTYQFQVR VSDGIWPDAV STVTVHVREL RDDAIYNSGS
LRLADITAKE FIELRGKQRS RYELLVDFLS EMLSVPPDDV NIFSLMDVKE RMLDVRFAVH
SGPSFLQPEK MHGYLAAHKQ KLQSFLQVSV FQVRVDECPS SECGGTGGCS NTLNVRDTPT
VVDCGTMSLV SVTVESTAVC SCPGREQSHQ PCATYPRNPC YNGGVCVDTQ HGYRCQCPAQ
FEGPECQQNK HSFHGNGYAW FPPMMPCFES HVSLEFITDV ADGLVLYSGP LAQLQAWDHE
DFMAIELIDG TPTLKINHGS GTVVLQLPGN VNVADRRWHR LDVRSNSKVG LRFTLDRCSG
AAVKELVGSW LTSQDHSSCE VMGVTHLNMS QVLQLGGVNE DIPYIYPQLQ HKHFTGCVRN
LIVDSKLYDL GSPADSQSSS PGCLTTDSSC VNMGYPSCGH RGRCHGEWGS FSCQCIPGYT
GHQCEEEVPE YSFDGHSHVR YQLASPLPAR RTWIQVLVRT RKHSSVLFSL ISKEQSEYLR
LEVSGLLCVF YNLGDGDYNL TLPTYRLDNG EWHEVFLDRH DNEMTLRMDG GGGQREVSGL
QGRSREIIID PTVVMLGNTF PSGINKSFQG RCQPRDGVSQ VSVQGLSVGC SSDSCKRNQC
SPPFTCVDLW RVHECRCPPG HMISVNGTKK SCVYTLCAMR PCHRGTCVAQ SPSKFTCHCP
EGYRGHRCET TLAIYREDVG LSFSSLFAIC ICFMALLGKS WLKEGVYHVS AHHDGWEDIR
ENVLNYDEEG GGEEDQNAYD MAELQKSLQP SPAQSVLRRD VPPTRLPAQG QARPSQLARR
SLSFSSQDLA RYLCEIIRDA DQHPDTGPFD SLQVFSTEGG GSPAGSLSSF SSAGLDGGSS
GEGGVEARRE ETLGEWGPRF EKLRALYERA EASDL
//