ID A0A3Q2W3J5_HAPBU Unreviewed; 4582 AA.
AC A0A3Q2W3J5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSHBUP00000019898.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000019898.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000019898.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR STRING; 8153.ENSHBUP00000019898; -.
DR Ensembl; ENSHBUT00000029379.1; ENSHBUP00000019898.1; ENSHBUG00000022356.1.
DR GeneTree; ENSGT00940000154906; -.
DR OMA; HYEDTSD; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.490.160; -; 3.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 3.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF7; RYANODINE RECEPTOR 2; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08709; Ins145_P3_rec; 2.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 3.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 1.
DR PROSITE; PS50188; B302_SPRY; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50919; MIR; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4008..4027
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4235..4255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4286..4306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4437..4461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4482..4504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 175..230
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 236..293
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 971..1168
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1290..1495
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3762..3788
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1288..1319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2296..2319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4063..4095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4118..4207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4068..4087
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4121..4138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4154..4192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4582 AA; 521209 MW; F104725C1E022693 CRC64;
ISLGGQGLGL DDEVVLQCSA TIHKEQQKLC LAAEGFGNRL CFLESISNSK NVPPDLSICT
FVLEQSLSVR ALQEMLANTQ EKADGVSVGM HTHIREESIN KYTVGEACWW TIHPASKQRS
EGEKVRVGDD LILVSVSSER YLHLSYGNGS LHVDAAFQQT LWSVAPICSG SEVAQGFLIG
GDVLRLLHGH MDECLTVPSG EHGDEQRRTV HYEGGAVSCH ARSLWRLETL RVVWSGSHIR
WGQPFRLRHV TTGKYLSMVE DKSLLLMDKE KADVKSTAFC FRSSKEKLDL GVRKDVDGMG
TPDIKYGDSV CYIQHVDTCL WLTYQTVDAK CARMGGVQRK AIMHHEGHMD DGLTLSRSQH
EESRTARVIR STVFLFNCFI RGLDILRKKG RSFTLDLPID SVSLSLQDLI GYFQPPGDHL
EHEDKQNRLR ALKNRQNLFQ EEGMISLVLE CIDRLHVYSS AAHFAEAVGK EAGEAWSAIL
NSLYQLLAAL IRGNRKNCAQ FSGSLDWLIS RLERLEACSG ILEVLHCVLV ESPEALNIIK
EEHIKSIISL LDKHGRNHKV LDVLCSLCVC HGVAVRSNQH LICDNLLPGR DLLLQTRLIN
HISSMRPNIF LGVSEGSAQY RKWYYELIVD QVLPFVTAEA THLRVGWGNT NGYAPYPSGG
EGWGGNGVGD DLYSYGFDGL HLWSGCIART VSSPNQHLLR SEDVVSCCLD LSVPSISFRI
NGQPVQGMFE NFNSDGLFFP VASFSAGVKV RFLLGGRHGE FKFLPPPGYA PCYEAVLPRE
KLKLEASQDQ TATRDQLGPT VTLSQAAFTP IPVDTSQIIL PPHLERIREK LAENIHELWV
MNKIELGWIY GAVRDDNKRQ HPCLVEFSKL PEQERSYNLQ MSLETLKTLL ALGCHVGLAD
EHAVEKVKNM KLSSTYELSS GYKPAPLDLS HIKLTSTQEA MVDKLAENAH NVWARDRIRQ
GWTYGIQQDL KNRRNPRLVP YALLDERTKK SNKDSLREAV RTLLGYGYNL EAPDQDHAAE
SGLSNVSAER FRIFRAEKTY CVNTGKWYFE LEVLTAGEMR VGWARPGCLP DQELGSDDQA
FVFDGFKVQR WHQGNEHFGR AWQIGDVVGC MVDLNEHTMM FTLNGEVLLD DSGSELAFKD
FEVGEGFIPV CSLGVCQAGR MNFGKDVSTL KYFTICGLQE GYEPFAVNMN RDVTMWLSKR
LPQFVPVPLH HQHIEVTRID ETIESCPCLK VTQKSFGSQN SYTDITFYRL SMPIECAETR
CPPNGSLFSP KRELEDFENV SDFEVLMKSS HSHNGPNGPD RDEFNNHKDY NQEKPSKLKQ
RLTLKRNKPD NSCPSSARVS EEVMADDRVS SDFLMQASTY YYSVRIFPGQ EPSSVWVGWV
TSDFHQYDPC FELHKVRTVT VTLGDEKGKV HESIKRSNCY MVWGGESSSP SQGRNNGLEI
GCLVDTTNGL LTFTANGKEL STYYQVEPST KLFPAVFAKA TSPNVFQFEL GRIKNVMPLS
AGLFKSEKKN PVSQCPPRLH VQFLTPVLWS RVSNHFLKVS VSRANDRHGW LVQCNKPLQF
MSLHIPEENR SLDILELSEQ KDLLKFHYHT LRLYSAICAL GNNRVAHALC SHVDEAQLLY
AIENKYMPGL LRAGYYDLLI DIHLSSYATA RLMMNNEYIV PMTNDTKSIT LFPNEKKKHG
LPGIGLSTSL RPRMHFTSPN FVSRPGPSCF NNGNSGSGDC FQYSPEFPLD ILKVKTIEML
TEAVREGSMH VRDPVGGSTE FLFVPLIKLL YTMLIMGVFQ NGDLKNILRL IEPSVFCERR
NKQDALCMEL EVLKKGEAEG GGKEGVLNVP KEGLLEMKLP EPVKLQMCHV LQYLCDCQVR
HRIEAVVAFS DDFVACLQEN QRFRYNEVML ALNMSAALTA KKTKEFRSPP QEQINMLLNF
KDEKQECPCP EYIREQLLDF HEDLMRHCGI ELDEERGINC DSDFTIRGRL MSLVEKVAYL
KKKMANLPKE KKDRKPSTLQ QLISDTMVRW AQESVIEDPE LVRAMFVLLH RQYDGIGGQV
RALPKTYTIN SVSIEDTINL LAALGQIRSL LSVRMGREEE KLMIRGLGDI MNNKVFYQHP
NLMRALGMHE TVMEVMVNVL SGGDSKEITF PKMVANCCRF LCYFCRISRQ NQKAMFDHLS
YLLENSSVGL ASPSMRGSTP LDVAAASVMD NNELALALRE PDLEKVVQYL AGCGLQSCVM
LVRKGYPDIG WNPVEGERYL DFLRFAVFCN GESVEENANV VVRLLIRRPE CFGPALRGEG
GDGLLAAMEE AIKISQDPSR DGPSPMSESS KALDMPGEEE DDTIHMGNAI MTFYSALIDL
LGRCAPEMHL IHAGKGEAIR IRAILRSLIP IEDLVGVISI SFSMPNLAKD GLVVEPDMSA
GFCPDHKAAM VLFLDRVYGI EDQNFLLHLL EVGFLPDLRS AASLDTVALS ATDMALALNR
YLCTAVLPLL TKCAPLFAGT EPFASLIDSL LHTVYRLSKG CCLTKAQRDS IEECLLAVCG
KLRPSMMQHL LRRLVFDVPL LNEHTKMPLK LLTNHYERCW KYYCLAGGWG NFGVASDEEL
HLSRKMFWGI FDALSHKQYD QELFKLALPC LSAVAGALPP EYMESNYMAM MEKQSSMDSE
GNFTPQPADT TNVTVPEKLD CFITRYAEHI HEKWCIEKQT VTLQDKETYC WPIRESLKTM
LSWGWSIDRI REGDSVNLHN KPRRISQASQ VYMNATHSYI SFSPRPTDMS NVTLSRDLQS
MAELLAENYH NIWSRKKKLE LEARGGGNHP LLVPYDTLTA KEKSKDREKA QDILKFLQIN
GYIVSRLELD TPAIEKRFAY TFLQQIITYV DQAHQHMMEF GKNLLMPVRA TCLHHQPGCS
LCFFSRQRPA MGKCLAAFAA AFPVAFLEPH MNKFNSFSIY NSKGSKDRAA LGLPGQVGEV
CSLIPNLEKS LEEIVELAES GMKYTQMPHV MEVVLPMLCS YMSHWWEHGP ESDPDKANNC
CTSVTSEYMN TLLGNILKII YNNLGIDEGA WMKRLAVFSQ PIISKAKPQL LKTHFLPLME
KLKKKAAVVL LDEEHSKAEG RGEMSETELL IMDQFTILVR DLYAFYPLLI RFVDYNRARW
LKESNPEAEE LFRMVAEVFI FWAKSHNFKR EEQNFVVQNE INNMSFLITD TKCKMSKGIV
SDQERKKMKR KGDRYSMQTS LIVATLKRLL PVGLNICAPG EQELIALAKN RFTQKDTEDE
VREVIRNNLH LQGKSEDPAI RWQMALYRDL PNHYEDTTDP EKTVERILDI GHVLFHLEQF
TEWFSLCLQV EHPQRSKKAV WHKLLSKQRK RAVVACFRMA PLYNLPRHRA VNLFLQGYEK
SWIETEEHYF EDKLIEDLAK PGEQEPSEEE EGQKHKHIDP LHQLIQLFSR TALTEKCLYV
FFHLSPFLQS CHDEEDDDGE VKSFEEKEME KQKLLYQQAR LHDRGAAEMV LQTISASKGE
MGPMVASTLK LGIAILNGGN STVQQKMLDY LKDKKDVGFF QSLAGLMQSC SVLDLNAFER
QNKAEGLGMV TEEGSGEKVM QDDEFTCDLF RFLQLLCEGH NSDFQNYLRT QTGNNTTVNI
IISTVDYLLR VQESISDFYW YYSGKDVIDE QGQRNFSKAI NVAKQVFNTL TEYIQGPCTG
NQQSLAHSRL WDAVVGFLHV FAHMQMKLSQ DSSQIELLKE LMDLQKDMVV MLLSMLEGNV
VNGTIGKQMV DMLVESSNNV EMILKFFDMF LKLKDLTSSD GFKEYDPDGK GVISKRDFHK
AMESHKHYTQ SETEYLLSCA ETDENELLDY EEFVERFHEP AKDIGFNVAV LLTNLSEHMP
HDTRLQTFLE LAESVLNYFQ PYLGRIEIMG SAKRIERVYF EISESSRTQW EKPQVKESKR
QFIFDVVNEG GEKEKMELFV NFCEDTIFEM QLAAQMSDAG ERLAIKEESE REKPDEENPD
VGFFSVTTVY MALLALRYNI MLLIKVLSMK SLKKQMKKIK NMTVKDMVTT LVSTYWSVLL
GLLHVAFNVA RGFCRIFYNT FIGENLVEGA KTIKVSELLA NMPDPTQDEV RGEGENREKR
SDHSSTGEDL ADLTVNTSET ELLSDIFGLD LRREGGQYKI TPHNPNASFT ELLNSPVPLP
TPSTAPQPEV RWRHQSSASE EMESKLESKC EPQKTSESDD VEKQEKQSKN ETMKPKMRRH
HTSKSDEPDV QESAFLKKII AYQRKLLNYF ARNFYNMRML ALFVAFAINF ILLFYKVTVP
RMFFMPQKPV TVRFVLEESS GYMEPMLRIL AVLHTVISFF CIIGYYCLKV PLVIFKREKE
VARKLEFDGL YITEQPSEDD IKGQWDRLVI NTQSFPNNYW DKFVKRKVMD KYGEFYGHDR
ISELLGLDKA ALDFSDAHKK RKPRKDSSLA AVLNSVDVKY QIWKLGVVFT DNSFLYLAWY
MTMSILGHYN NFFFAAHLLD IAMGFKTLRT ILSSVTHNGK QLVLTVGLLA VVVYLYTVVA
FNFFRKFYNK SEDGELPDMK CDDMLTVSMT CIRLFFLMYL INKDETEHTG QESYVWKMYQ
ERCWEFFPAG DCFRKQYEDQ LN
//
