ID A0A3Q2W4B8_HAPBU Unreviewed; 467 AA.
AC A0A3Q2W4B8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Potassium channel subfamily K member 4-like {ECO:0000313|Ensembl:ENSHBUP00000019611.1};
GN Name=KCNK4 {ECO:0000313|Ensembl:ENSHBUP00000019611.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000019611.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000019611.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR RefSeq; XP_005932001.1; XM_005931939.1.
DR STRING; 8153.ENSHBUP00000019615; -.
DR Ensembl; ENSHBUT00000028992.1; ENSHBUP00000019611.1; ENSHBUG00000021852.1.
DR Ensembl; ENSHBUT00000029008.1; ENSHBUP00000019615.1; ENSHBUG00000021852.1.
DR GeneID; 102294680; -.
DR GeneTree; ENSGT00940000160310; -.
DR OMA; YMEGWSK; -.
DR OrthoDB; 600333at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003976; 2pore_dom_K_chnl_TREK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF30; POTASSIUM CHANNEL SUBFAMILY K MEMBER 4; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01499; TREKCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..467
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041077431"
FT TRANSMEM 87..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..137
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 175..256
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 287..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..311
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..436
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 467 AA; 52016 MW; 73BE5AC3E212A45B CRC64;
MRCSTLLAIL TGVLLYLVLG AVVFRALEAP QEEGVHMKLQ DTRRDFLLNF SCVDSDKLEV
LIEEVVEATG AGVDPIGNAT FVSKWDLASA FFFSGTIITT IGFGNISPKT EGGQLFCIFY
ALVGIPMFGI LLAGVGDHLG TGLRKTVAKI EKLFLKWRVS PTIVRVISAV LSILLGCVLF
VALPIFIFQE VEEWTLLESA YFVVITLTTV GFGDYVAGDS GKEGSDHWYK PLVWFWILLG
LAYFASILTM IGNWLRVLSK KTRAEMEELR AHATDWTQNI QNMSVDFRMP GKIDDPFKRR
RRKRRHGPRS HGHSVSANGV PEGQEEQRES QEESGSYSSS SSSSSNESGS GSETDSQATQ
TERVPEEKPA KPKQEEAPPD PHLSQPLDYF GENLAFIDES SDTQSGKLHL DPLLNPTKPN
PRQPKRRRHR RPVPQRNHKN NSPNSTNKKE PNRNPRSVPD LPPKPCE
//
