ID A0A3Q2W5B2_HAPBU Unreviewed; 2079 AA.
AC A0A3Q2W5B2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Desmoplakin-like {ECO:0000313|Ensembl:ENSHBUP00000020633.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000020633.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000020633.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004236}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 8153.ENSHBUP00000020633; -.
DR Ensembl; ENSHBUT00000036009.1; ENSHBUP00000020633.1; ENSHBUG00000022900.1.
DR GeneTree; ENSGT00940000154843; -.
DR OMA; EESCNQR; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 3.
DR Gene3D; 3.90.1290.10; Plakin repeat; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR23169:SF26; DESMOPLAKIN; 1.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR Pfam; PF00681; Plectin; 5.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00250; PLEC; 9.
DR SMART; SM00150; SPEC; 4.
DR SUPFAM; SSF75399; Plakin repeat; 3.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 480..545
FT /note="Desmoplakin SH3"
FT /evidence="ECO:0000259|Pfam:PF17902"
FT DOMAIN 580..657
FT /note="Desmoplakin spectrin-like"
FT /evidence="ECO:0000259|Pfam:PF18373"
FT REGION 190..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 344..371
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 414..473
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 637..751
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 882..943
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1139..1317
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1342..1436
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2079 AA; 235815 MW; 94FC79851977C2F4 CRC64;
MSAYGSQQAL NMLRRANSRG ELTGESTYQY ARSDGFHGGG NGYDQYGHDG HKTFTYSKSV
KGGGMASGMA SSMRAGTTRG MTWRGASMGG GAMSGAGGGA ISGMGGSTLT SINQKAAILQ
SQCNEYLQKA EYYIQAGGNP SEVEYFMGMA KEAIQNLKSC GADLRQMGQP NENVMRSVEM
YNSQLKGVHK AISGTTQRRK STKGGSIGWE EPGRSYHDAM GWIAQQKRLI ETASWGDDSA
AIEQQLMSHQ RFHSSIQRSV EFDRARDDLM KTGDKANLKA LDQEWDNLQK TSHDRMQQLR
EFQQIIQEIS KEIMWVNEKE EEELMFDWGD KNIDQYIPRK QESYSKLMSA LEVKEKDLNR
LKAKVDNLLK NDHPASDKIE AYSDTLQTQW SWLLQITKCI DTHLKENLAY SQFFKEANET
YSALQKEHET VRKNFICDKN TSLETLQELL RNLEREKEKI VENRRQVKHL VSKSKEIVRL
KPRNPEEKNT SGVIVKALCD FKQDQKVILK GNEAILKDNN QRSKWLVTGP GGLDMLVPSV
CLIVPPPNPI SISLANKNEQ YYEAILSIWS QLYINVKSLI SWQYCVMDIQ RINSLTISML
AKMRPEEYRK MIKSMETHYD EFIVNSVNSQ MFADEDKRSI ENQVNDAQTH YEQLVVQIPT
YIVQQEQLQQ TSGQQHQLII LQQQQVQAAA AEDARRLEEE ARMRQEEAWR LEEEARMHQE
EARRLEEERR RAELRRQAEK KAEAKKEVVR KEVIKVTKTD AGKRKVSTST SSSSHSLLEL
HSLRLRLEAA EDMLSQHIHV CFGDNGVQDC SLKISQLETV QRDVDSMRAE YLLLKERILN
ELESVNDSDK AQFLRSEIGV INQRLGSLES SSTAYVQRLR ALRDMLESVA RAEDIVKVYE
ARMTEKETTS LSPEEVEEYM STLKNIKAEL DQKKDILNAM EAELSKASHW NGQVGGSSHR
CDLMLTKYTE DVNMLSDRWR RIQLQLDTRM QDLRSYLPQL QHYKQTSTSI LEWIEATRRK
QVALQATKIE NVQALENLIN NQKALNAEIK VRRETVDSVL KDNEACVNAI KDYETDLAAY
TSGLETLLNI PVKRTMLKSP SVDLNHEATQ LQTRYMELLT LSDDYYRFLG DLLRNMEELK
IRNTRIDLLE EELRLLRDDM RDRNAKNKSL EDALAQYQRE LNQSKEQLLS MEEVKQTASL
QCSATKENLD NTQSQLAGLR DQVERLNYLL DEEKRKRKLA EERYTQQQEE YEAVLRKRQN
ELETVSWSKV EVEKTLSNKE LEIEQLRRQL ADETARFMEL QKEISKIRAT MQSLQSQYNE
IVTERDTLLL KLQLSEKDKD HILRLEEELS RIKLSLESEY RNKQRLQEEN ERVKRDLSHW
KDQCDSKHGL IRQYETDKDI SEREKKSLKS EIERLMRELR ELEESYKIKL SATQKELHEV
TIVRKNIETE LKTAREPPTL DPSTLIFDGV RKTVTADQLL NCGVLDKQTC NQLVKGHRTV
PEVSVDKKVN LKGTGPIAGV VVEGLKGPGS ISGPQFAKLT FTEAKNENLL PADAINLLLD
AQAATGHIID PRTNQKLTVE EACNHGVIDD KDRERLLAAE AAAVGYNGPG TNKPLSVFQA
MKMGLIDRNT TLRLLQAQES VGGILDPVLS VFLPKDTAIE RGLIDDNLCR ALSQRPELYL
DPENEDGVTY MSMKRRCKVE PHTGLLLLPV TEKIDPSKLI FDGVRKPVTA KQLLDCSVLD
KPTFKDLEKG KKTIPEVSVD KNVNLKGTGP IAGVVAGKQG KMSLSEAKRQ MLLPEDTADL
LLEAQAATGH IIDPQTNQKL TVEEACTRGV VDIRDRDKLL AAEAAAVGYK DPKVAKPLSV
FEAMKKGLID NKTALRLLQA QESVGGILDP NLSVFLPKDT AIKRNLLDEN LRHALKQDPE
CYIDPETEHD ASYETLKKRC KIEPHTGLLL LPVSEKLDPT KLVFDGVRKP VTAKDLLDCG
VLDKPTFNQL LKGEKTVPEV SADKKISLKG TGVIAGVVAG PLGKLSLSEA KKQMLMPLDS
VDLLLEAQAA TGHIIDPISN QKLTVEEACA RGVVDSSDR
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