ID   A0A3Q2W5I8_HAPBU        Unreviewed;       801 AA.
AC   A0A3Q2W5I8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=HHIP-like protein 1 {ECO:0000313|Ensembl:ENSHBUP00000016459.1};
GN   Name=HHIPL1 {ECO:0000313|Ensembl:ENSHBUP00000016459.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000016459.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000016459.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the HHIP family.
CC       {ECO:0000256|ARBA:ARBA00010658}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR   RefSeq; XP_005949622.1; XM_005949560.1.
DR   AlphaFoldDB; A0A3Q2W5I8; -.
DR   STRING; 8153.ENSHBUP00000016459; -.
DR   Ensembl; ENSHBUT00000034214.1; ENSHBUP00000016459.1; ENSHBUG00000018418.1.
DR   GeneID; 102307847; -.
DR   CTD; 84439; -.
DR   GeneTree; ENSGT00940000162083; -.
DR   OrthoDB; 344738at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR018143; Folate_rcpt-like.
DR   InterPro; IPR012938; Glc/Sorbosone_DH.
DR   InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   PANTHER; PTHR19328; HEDGEHOG-INTERACTING PROTEIN; 1.
DR   PANTHER; PTHR19328:SF32; HHIP-LIKE PROTEIN 1; 1.
DR   Pfam; PF03024; Folate_rec; 1.
DR   Pfam; PF07995; GSDH; 1.
DR   Pfam; PF00530; SRCR; 1.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00202; SR; 1.
DR   SUPFAM; SSF50952; Soluble quinoprotein glucose dehydrogenase; 1.
DR   SUPFAM; SSF56487; SRCR-like; 1.
DR   PROSITE; PS50287; SRCR_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00196}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          692..793
FT                   /note="SRCR"
FT                   /evidence="ECO:0000259|PROSITE:PS50287"
FT   REGION          648..681
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        666..681
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        762..772
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ   SEQUENCE   801 AA;  90677 MW;  74CF58CD2C6FF8F0 CRC64;
     MQRCCGKITS HLWLWSTLLF LTLCFAPVML HPQCLDFKPP FRPQKELEFC IMYKEFGCCD
     YQKDQELMSK YYQIMDNFDY SGYTSCAGFI FDLLCQECSP YAAHLFDAED PSTPVRTIPG
     LCSEYCFQFW NKCSFTIPFL SGDPYIANFR ENQTSLCHYL EIHDKDYCYP YLLNNQQLTQ
     NLGGIQVNSD GCLQLCLEEV ANGLQNPLAM VHANDGTHRF FVAEQVGLVW TYLPDRSKLE
     RPFLNITQAV LTSSWEGDER GFLGLAFHPK YKYNGKLYVY YSVEVGFDER IRISEFHVSA
     NDMNEVDHTS ERVILEIDEP ASNHNGGQLL FADDGYLYIF TGDGGMAGDP FGKYGNAQNK
     SALLGKVLRI DVDDNQRGPL YRIPPDNPFI HEQGARPEVY AYGVRNMWRC SVDRGDPWTK
     DGKGRIFCGD VGQNKFEEID IIEKGRNYGW RAKEGFSCYD KKLCANSSLD DVLPVYAYPH
     RMGKSVTGGY VYRGCEYPNL NGIYIFGDFM SGRLMSLQED KKTGNWKYNE ICMGMGLTCA
     FPGLINNYHQ YIISFAEDES GELYFMSTAI PSATSPSGVV YKVIDPSRRA PPRQCHYDPL
     PVRVKSNLIK FVPQETLVGI DLPNENFEPQ STESYQWHQE LSDHRGETGA GLITPVPATG
     TSKTTKNSRR KGRHRKNKSK LERAPHIQTG AVRLVGDSRS DRGRVEIYIN GEWGTVCDDL
     WTLVNARVIC RQLGFQHALK AAKNSEFGEG KDLRILLDDV KCVGTESSLL DCRHAGVGTH
     NCAHYEDAGV ICGNSSYVAE V
//