ID A0A3Q2W8I6_HAPBU Unreviewed; 525 AA.
AC A0A3Q2W8I6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=T-box transcription factor TBX5-A-like {ECO:0000313|Ensembl:ENSHBUP00000021331.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000021331.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000021331.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR RefSeq; XP_005930121.1; XM_005930059.1.
DR AlphaFoldDB; A0A3Q2W8I6; -.
DR STRING; 8153.ENSHBUP00000021331; -.
DR Ensembl; ENSHBUT00000031164.1; ENSHBUP00000021331.1; ENSHBUG00000023661.1.
DR GeneID; 102296810; -.
DR CTD; 30071; -.
DR GeneTree; ENSGT00940000156506; -.
DR OMA; YPLAQEH; -.
DR OrthoDB; 5323209at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0003294; P:atrial ventricular junction remodeling; IEA:Ensembl.
DR GO; GO:0036302; P:atrioventricular canal development; IEA:Ensembl.
DR GO; GO:0003190; P:atrioventricular valve formation; IEA:Ensembl.
DR GO; GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0061026; P:cardiac muscle tissue regeneration; IEA:Ensembl.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IEA:Ensembl.
DR GO; GO:0003146; P:heart jogging; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0060174; P:limb bud formation; IEA:Ensembl.
DR GO; GO:0021554; P:optic nerve development; IEA:Ensembl.
DR GO; GO:0003344; P:pericardium morphogenesis; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0003342; P:proepicardium development; IEA:Ensembl.
DR GO; GO:0060042; P:retina morphogenesis in camera-type eye; IEA:Ensembl.
DR CDD; cd20189; T-box_TBX4_5-like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF28; T-BOX TRANSCRIPTION FACTOR TBX5; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 57..237
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 58330 MW; 571748D6BA9043EF CRC64;
MADQEETFVL QNSPGGSDSR ELQSDNKSEK QNGTSSKSPS SQTTYIQQGM EGIKVYLHER
ELWTKFHEVG TEMIITKAGR RMFPSFKVKV TGLNPKTKYI LLMDVVPADD HRYKFADNKW
SVTGKAEPAM PGRLYVHPDS PATGAHWMRQ LVSFQKLKLT NNHLDPFGHI ILNSMHKYQP
RIHIVKADEN NGFGSKNTAF CTHVFPETSF IAVTSYQNHK ITQLKIENNP FAKGFRGSDD
MELHRMSRMQ STKEYPVVPR STVRQRVGSS QSPFSGEVQG LATPNSLSSQ YSQCENGVTS
SSQDMLPQSG SYPLPHEHGQ EYHCIKRKVD DDCHSGDHSY KKAYLESSSS EEDHYYRPVG
YAQSLSLSGG PYRSESSQRQ ACMYASASQS AEPVPSLEDI SCNTWASVSP YGSCSVTTMQ
PMDRLPYQHF SAHFTSGSLV SRLGGVGGHA SPQLGDGHHA AMYQSSMTHQ TLGRQCSPGA
GIQSPAASLQ GNEYLYTHGI PRTLSPHQYH SVHSVSIMPE WSENS
//
