ID A0A3Q2W9U0_HAPBU Unreviewed; 397 AA.
AC A0A3Q2W9U0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Protein CYR61-like {ECO:0000313|Ensembl:ENSHBUP00000018204.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000018204.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000018204.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000256|ARBA:ARBA00008125}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR RefSeq; XP_005926772.1; XM_005926710.1.
DR AlphaFoldDB; A0A3Q2W9U0; -.
DR Ensembl; ENSHBUT00000027212.1; ENSHBUP00000018204.1; ENSHBUG00000020272.1.
DR GeneID; 102293850; -.
DR GeneTree; ENSGT00940000165172; -.
DR OMA; VRPCSSM; -.
DR OrthoDB; 2970572at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR012395; IGFBP_CNN.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR PANTHER; PTHR11348:SF20; PROTEIN CYR61; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR Pfam; PF00093; VWC; 1.
DR PIRSF; PIRSF036495; IGFBP_rP_CNN; 2.
DR SMART; SM00041; CT; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..397
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018694402"
FT DOMAIN 15..90
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 94..160
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 301..375
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
SQ SEQUENCE 397 AA; 43881 MW; 92D3097DC32BF04C CRC64;
MGTLLLFAAL QVVTVASVTA ECPVVCECPA VPPSCPPGVS SVPDGCGCCK VCAAQLNQDC
HEGRPCDHHK GLECNYGNDV GRTHGICRAK AEGRSCEYSG RIYQNGENFR AGCKHQCTCI
DGAVGCVPLC PSHVPLASPS CPAPQLVKVP GQCCLSIDCH KGTTVMPPVY RRPQPPAFPP
YPPFIPYPVY PYPKPFPKPY RKFYTYKHKK EKDTLGNELV EAVRKWGKPR GNKHLAAWKQ
TSDECVVQTT SWSECSRSCG MGVSSRVTND NAQCKMIKET RLCNIRPCSS MSIPVKKGRK
CSRTHKAPEP HRLSYAGCRS TRLYRPNYCG VCRDGRCCSP RRTRTANVTF ACPDGERFSR
SVMFIQSCKC SDECNHLNEA VMPPQLWLYG DTHKFND
//
