ID A0A3Q2WA78_HAPBU Unreviewed; 563 AA.
AC A0A3Q2WA78;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Shisa family member 9 {ECO:0000313|Ensembl:ENSHBUP00000021720.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000021720.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000021720.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Regulator of short-term neuronal synaptic plasticity in the
CC dentate gyrus. Associates with AMPA receptors (ionotropic glutamate
CC receptors) in synaptic spines and promotes AMPA receptor
CC desensitization at excitatory synapses.
CC {ECO:0000256|ARBA:ARBA00037492}.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendritic spine membrane
CC {ECO:0000256|ARBA:ARBA00029429}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00029429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the shisa family. SHISA9 subfamily.
CC {ECO:0000256|ARBA:ARBA00038448}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005938066.1; XM_005938004.1.
DR AlphaFoldDB; A0A3Q2WA78; -.
DR Ensembl; ENSHBUT00000015513.1; ENSHBUP00000021720.1; ENSHBUG00000001583.1.
DR GeneID; 102293604; -.
DR CTD; 541382; -.
DR GeneTree; ENSGT00940000163663; -.
DR OMA; MTHNLMT; -.
DR OrthoDB; 5350575at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0032591; C:dendritic spine membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31774:SF1; PROTEIN SHISA-9; 1.
DR PANTHER; PTHR31774; PROTEIN SHISA-9-RELATED; 1.
DR Pfam; PF13908; Shisa; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..563
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018774651"
FT TRANSMEM 136..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 400..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..439
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 563 AA; 61024 MW; C7107FFA28B17CA1 CRC64;
MRGKHFLPCF LLLKLMALVC KAGGIPGALG GFVMIATSNG STPEESVSEQ TPHTEERCRG
YYDVMGQYDP PFICKTGVYL YCCGTCGFRF CCSIKESRLD QETCTNYDTP MWMKSGQTPY
KKTNKPHDST KDKTNLIVYV ICGVVAIMAL VGIFTKLGLE KAHRPQRENM YRVVANVLQG
GCPGEQYRGE EALGMHSQHY VARATNIQGG QINNNVGPAS NMGQQHPYPA LGQLSHVYEQ
QQQQQQLHQQ QQQQQQNKDL NKYASLKAVA AKYNGELYNK RRLMVEMPAK GLPLQPMGNS
RPSMASMGNM SSVTPQMTTN PMASNPMSAN PINHVMTPMT SMTPMTSLTP MTSMTPMTSL
TPMTSMTPMT SLGPLTPEPV ATYVTEMPSI SSVSTLPTER HIAAGGGGGH KPNGQKPKVS
HGHTAHSSHS SHSSHTHLHS HSSKPPGLGA TSLAHMAGTM PGGTSLGISR AAETVIGHGS
ATMGRPLAYS SNTIASSHAM GLGLKGWDGT ETVGRRKTYG HKRPQCTILE PNQLHSTRGH
SHSQHFLPTQ PYFVTNSKTE VTV
//