ID   A0A3Q2WAF9_HAPBU        Unreviewed;       504 AA.
AC   A0A3Q2WAF9;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=T-box transcription factor 22 {ECO:0000313|Ensembl:ENSHBUP00000022116.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000022116.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000022116.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00201}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_005916608.1; XM_005916546.1.
DR   AlphaFoldDB; A0A3Q2WAF9; -.
DR   STRING; 8153.ENSHBUP00000022116; -.
DR   Ensembl; ENSHBUT00000014510.1; ENSHBUP00000022116.1; ENSHBUG00000002184.1.
DR   GeneID; 102295824; -.
DR   CTD; 50945; -.
DR   GeneTree; ENSGT00940000155566; -.
DR   OMA; KPLHCRD; -.
DR   OrthoDB; 5323209at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0009790; P:embryo development; IEA:UniProt.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd20200; T-box_TBX22-like; 1.
DR   Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR   PANTHER; PTHR11267:SF116; T-BOX TRANSCRIPTION FACTOR TBX22; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00201};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          109..296
FT                   /note="T-box"
FT                   /evidence="ECO:0000259|PROSITE:PS50252"
FT   REGION          19..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..104
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   504 AA;  56531 MW;  E8800CE95EF77677 CRC64;
     MQGLSSRAHA FSVEALVGKP CKRIKVSEEH EPSSADTSGD RSIFPDQNKY PINQLQKACP
     TPRRGEDPSA CDPQGQTDRS QTEDSDPSSE EKKPKESDCR PDREVRVELQ GSELWRRFYE
     IGTEMIITKA GRRMFPSVRV KVRNLDPCQQ YYIAMDVMPV DSKRYRYVYH SSQWMVAGNT
     DHSCISPRLY VHPDSPCAGE TWMRQVISFD RVKLTNNEMD DKGHIILQSM HKYKPRVHII
     KHNPRMDLSQ IQSLPADGVH SFSFPETEFT TVTAYQNQQI TKLKIDRNPF AKGFRDPGRN
     RGVLDGLLES YPWRGPFSLD FKPFTIQLQG SSGSPTSSVK SLLPVSSSSS LHPLSCQEAA
     VHAFTLPLYS KTSTTSPSIS PLPSRAFSSL GADRLRGFSP LPPLTDLPLF SALQGKKPPH
     CRDPCPHESP GSPCLLPLHC PLSPQSSPLP PHLSDTVSPY CLYRYSFPLN PQLAAISRHP
     KLAEDTTDCL LRQPPWLPTT NHCL
//