ID   A0A3Q2WBT5_HAPBU        Unreviewed;      1073 AA.
AC   A0A3Q2WBT5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=ferroxidase {ECO:0000256|ARBA:ARBA00013107};
DE            EC=1.16.3.1 {ECO:0000256|ARBA:ARBA00013107};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000023268.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000023268.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O;
CC         Xref=Rhea:RHEA:11148, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.16.3.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001830};
CC   -!- SIMILARITY: Belongs to the multicopper oxidase family.
CC       {ECO:0000256|ARBA:ARBA00010609}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_005923949.1; XM_005923887.1.
DR   AlphaFoldDB; A0A3Q2WBT5; -.
DR   STRING; 8153.ENSHBUP00000023268; -.
DR   Ensembl; ENSHBUT00000011549.1; ENSHBUP00000023268.1; ENSHBUG00000003968.1.
DR   GeneID; 102305063; -.
DR   CTD; 1356; -.
DR   GeneTree; ENSGT00940000155866; -.
DR   OMA; HVTDHIS; -.
DR   OrthoDB; 537265at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 4.
DR   InterPro; IPR011707; Cu-oxidase-like_N.
DR   InterPro; IPR011706; Cu-oxidase_C.
DR   InterPro; IPR033138; Cu_oxidase_CS.
DR   InterPro; IPR002355; Cu_oxidase_Cu_BS.
DR   InterPro; IPR008972; Cupredoxin.
DR   PANTHER; PTHR46806:SF7; COAGULATION FACTOR VIII; 1.
DR   PANTHER; PTHR46806; F5/8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF07731; Cu-oxidase_2; 2.
DR   Pfam; PF07732; Cu-oxidase_3; 2.
DR   SUPFAM; SSF49503; Cupredoxins; 6.
DR   PROSITE; PS00079; MULTICOPPER_OXIDASE1; 2.
DR   PROSITE; PS00080; MULTICOPPER_OXIDASE2; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..1073
FT                   /note="ferroxidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018545483"
FT   DOMAIN          96..206
FT                   /note="Plastocyanin-like"
FT                   /evidence="ECO:0000259|Pfam:PF07732"
FT   DOMAIN          262..358
FT                   /note="Plastocyanin-like"
FT                   /evidence="ECO:0000259|Pfam:PF07731"
FT   DOMAIN          811..870
FT                   /note="Plastocyanin-like"
FT                   /evidence="ECO:0000259|Pfam:PF07732"
FT   DOMAIN          959..1064
FT                   /note="Plastocyanin-like"
FT                   /evidence="ECO:0000259|Pfam:PF07731"
SQ   SEQUENCE   1073 AA;  122349 MW;  1F95AE6ED08AE354 CRC64;
     MLRLDLRAVL LLFCVVTCVS GMRREYFLKI EEVSWNYAPT GMNIIQNRSI QDDEEASVFL
     KSGPQRIGST YKKAVYKQYS DATYRTELTK AEWLGYLGPL LMAEEGDTLI VHLKNTASRP
     YSAHPHGLNY TKGNEGALYP DGTGPELKRD DSVPPGQTVT YEWTLAESHS PTSHDSNCMT
     RFYHSHVSPP KDINSGLIGP LIVCKRGTLD LHGDSSADYQ YALLFMVSDE NFSWYLDENI
     RTYITNPARN LKEDEDFIES NKMHGINGLL YGNLRGLSMC QGNKIQWHLF ALGNEVDMHS
     VHFHGQILTT MNHHTDTISL FPALSTTAEM VADNPGHWLL ACSVNDHLMA GMQALFEIKK
     CFPNVHKPRP YGEQRQYFIA AEEEVWDYAP TVPTDGAAET FVTRGRNRIG SRYKKVRYVE
     YTDNTFMTKM LRSPEDQHLG ILGPVLKAEE KDTIRVVFKN KASRPYTIQP HGVQYSVEQD
     GTLYHNELEE SYTDKKLREL KRLPRVVTPP PAALVRPGMV HIYEWMVPVG AGPVEGEADC
     LTYLYYSAVD PVKDTSSGLV GPLLICRPKS LKKGVQKNYN KEFHLMATVF DENLSWYLDD
     NIRTFTTAPN TVNKEDEGFI ESNKMHAING FVYNNLPGLT MCKGDKVSWH LSGLGSETDI
     ISLYFQGNRF IYEQNRRDTI SVFPHISHTV TMEPDSMGQF EVVSATVNHY RNGMRANYTV
     EKCSILHRQS EMMLHSKTYY IAAMEIDWDY APNRTWEVEM FRGMESPAPV FLDKQGGFIG
     SRYKKVVYRQ FTSDKFTKQV ERTADMEHLG IMGPMIHANV GDKVKVVFKN MATRPYSIHA
     HGVKTENPSV HQTQPGEIHT YYWYVNKNTG PTTEQEECSV SAYYSTVDVA KDLYSGLIGP
     LVVCRRSWGR TLGLKKEVEE FALLFLVFDE NESWYLDENI RAQIRNPRPN LKDDEDFIES
     NKMHAINGYV YANLNGLNME VDDKVYWYLM GMGNEVDIHT AHWHGHSVEY KLGGGAHRAD
     VYELFPATFQ TVKMRPQYPG TWLLHCHVTD HIKAGMEAMY TVTEKPKKSG IFG
//