ID A0A3Q2WC34_HAPBU Unreviewed; 522 AA.
AC A0A3Q2WC34;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Acid sensing ion channel subunit 1 {ECO:0000313|Ensembl:ENSHBUP00000022786.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000022786.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000022786.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. ASIC1 subfamily. {ECO:0000256|ARBA:ARBA00038517}.
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DR RefSeq; XP_005943319.1; XM_005943257.2.
DR AlphaFoldDB; A0A3Q2WC34; -.
DR Ensembl; ENSHBUT00000012748.1; ENSHBUP00000022786.1; ENSHBUG00000003248.1.
DR GeneTree; ENSGT00940000168601; -.
DR OMA; MECSPED; -.
DR OrthoDB; 3415680at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR Gene3D; 1.10.3590.10; acid-sensing ion channel 1 domain; 2.
DR Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 2.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF170; ACID-SENSING ION CHANNEL 1; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 45..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 522 AA; 59894 MW; 3929D45A09B80D63 CRC64;
MDLKADSEDM DYRRPAPIEV FAARSTLHGI SHMFTYKRMY IKRTLWILFF LASVGVLVMV
CVDRVQFYFE YPHVTKLDEV AASLIIFPSV TFCNLNSFRF SRVTRNDLYH AGEFLALLNG
RYEIRDPHLV EENVLQILKE RADFDSYKPR PFNMREFYDR TGHDIKDMLL SCSYRGEECA
AEDFKVIFTR YGKCYTFNSG KDGKPLQVTT KGGMGNGLEL MLDIQQDEYL PVWGETDETS
FEAGIKVQIH TQDEPPFIDQ LGFGVAPGFQ TFVSCQEQRL TYLPPPWGDC KSTPMDSDFF
SSYSITACRI DCETRYLVDN CNCRMVHMPG NAPYCTPEQY KECADPALDF LVEKDNDFCV
CETPCNLTRY GKELSFVKIP SKASAKYLAK KYNKTEQYIA DNILVLDIYF EALNYETIEQ
KKAYELAGLL GDIGGQMGLF IGASILTILE LIDYLYEVIK YKVCRCMKKK HKGRKNNDRG
AVLSLDDVKH HAPCENLRTP STYPGNMLPH HPGQGNFEDF TC
//
