ID A0A3Q2WDC4_HAPBU Unreviewed; 622 AA.
AC A0A3Q2WDC4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=REL proto-oncogene, NF-kB subunit {ECO:0000313|Ensembl:ENSHBUP00000023868.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000023868.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000023868.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005949296.1; XM_005949234.2.
DR AlphaFoldDB; A0A3Q2WDC4; -.
DR STRING; 8153.ENSHBUP00000023868; -.
DR Ensembl; ENSHBUT00000010017.1; ENSHBUP00000023868.1; ENSHBUG00000004908.1.
DR GeneID; 102309923; -.
DR CTD; 5966; -.
DR GeneTree; ENSGT00940000158732; -.
DR OrthoDB; 1059550at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR PANTHER; PTHR24169:SF4; PROTO-ONCOGENE C-REL; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 16..193
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 395..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 70438 MW; 7AFACF61EB63A5D8 CRC64;
MDVLMSSVLR DEAHLLPEPG IQIFEQPKQR GMRFRYKCEG RSAGSIPGEK SSDNNRTYPS
LQILNYCGKG KVRVYLVTKN EPYRPHPHDL VGKDCKDGFY EAEFGPDRRV IAFQNLGIQC
VRRREVKEAI IQRITRGINP FNVPREQLLQ TEEYDLNVVR LCIQVFLQDE NGHYTRALNP
IVTNPIYDNR APNTAELRIC RVNRNSGSVR GGDEIFLLCD KVQKDDIEVR FFSPDGWEAK
GSFSQADVHR QVAIVFKTPP YHNTSITDSV TVHMQLRRPS DQEVSEPMDF RYLPDDKDPY
GYNEKKRRRE HLMKISGLSG GPFSGLTMNR PKAVPQSTMS HLKRDMGNAY PRQQQQPSMF
TQAYQQAPQN LMAPNLQLSH AWANSNPTLS MDTVTINPGA SNLPRPVSRQ QPPNRSYQHR
VDHNSCENNA LPQLSMRDLQ CLDTGSQAPV MREPEQLFHQ QNQREELRSE TPNQAQNHLV
SQNQGIQWSN FTTMGSVPNP FNGSGGGGGS QGVGSFPFLE GIEENDFLKN MAGAPQPCFQ
LKQESQISVG QESHTPLMQS PRESQGNTYT NLLPRPMSNG TNRDPMRPDG TAIKNLHSPY
VNNGMTAEAH YATLEDWMNQ ND
//
