ID A0A3Q2WE92_HAPBU Unreviewed; 1271 AA.
AC A0A3Q2WE92;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=DEAH box protein 9 {ECO:0000256|ARBA:ARBA00031576};
DE AltName: Full=Nuclear DNA helicase II {ECO:0000256|ARBA:ARBA00033216};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000023365.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000023365.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR RefSeq; XP_005945842.1; XM_005945780.2.
DR RefSeq; XP_005945843.1; XM_005945781.2.
DR RefSeq; XP_014196668.1; XM_014341182.1.
DR AlphaFoldDB; A0A3Q2WE92; -.
DR STRING; 8153.ENSHBUP00000023365; -.
DR Ensembl; ENSHBUT00000011296.1; ENSHBUP00000023365.1; ENSHBUG00000004129.1.
DR GeneID; 102289773; -.
DR CTD; 1660; -.
DR GeneTree; ENSGT00940000155924; -.
DR OMA; RFKCELR; -.
DR OrthoDB; 1095660at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0033679; F:3'-5' DNA/RNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-KW.
DR CDD; cd17972; DEXHc_DHX9; 1.
DR CDD; cd19854; DSRM_DHX9_rpt1; 1.
DR CDD; cd19855; DSRM_DHX9_rpt2; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044447; DHX9_DEXHc.
DR InterPro; IPR044445; DHX9_DSRM_1.
DR InterPro; IPR044446; DHX9_DSRM_2.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF119; ATP-DEPENDENT RNA HELICASE A; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW Transcription {ECO:0000256|ARBA:ARBA00022472};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00022472};
KW Transcription termination {ECO:0000256|ARBA:ARBA00022472}.
FT DOMAIN 3..71
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 197..269
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 415..581
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 652..825
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 603..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1271 AA; 139735 MW; DE98F438B9EFA165 CRC64;
MADIKNFLYA WCGKKKLTPN YDIRAAGNKN RQKFMCEVRV DSFNYIGMGN STNKKDAQTN
AARDFVNYLV RIGEMNAAEV PALGASAPIA DQPDAAADAG FGNLPSSGPL PPHLVVKAEQ
GDSSVSGPVP GVTGLGYAGA GNSGWGRGGS DGGAQWDRGA NLKEYYAKRD EQEAQATLES
EEVDLNANLH GNWTLENAKA RLNQFFQKEK TSAEYKYSQV GPDHNRSFIA EMQLFVKQLG
RRITAREHGS NKKLAAQSCA LSLVRQLYHL GVIEAYSGVT KKKEGETLEA FEVNVSPDLQ
QQLACVVQEL GVSVPPPPAD PSSPVSLVQG KLAYFEPSQR QTGAGVVPWS PPQVNWNPWT
SSNIDEGPLA YCPPEQISGD LHDELQYQLE HDENLQKILM EREQLPVKQF EEEIMAAIDK
SPVVIIRGAT GCGKTTQVPQ YILDRFIKGG RASDCNIVVT QPRRISAVSV AERVAFERAE
DLGKSCGYSV RFESVLPRPH ASILFCTVGV LLRKLEAGIR GISHVIVDEI HERDINTDFL
MVVLRDVVQA YPDVRIILMS ATIDTTMFRE YFFSCPVIEV FGRTFPVQEY FLEDSIQMTK
FVPPPMDRKK KDKDEEGGDD DTNCNVICGP EYTPETKHSM SQINEKETSF ELVEALLKYI
ETLQVAGAVL VFLPGWNLIY SMQRHLESNP HFGSNRYRIL PLHSQIPREE QRRVFEPVPD
DIRKVILSTN IAETSITIND VVYVIDSCKQ KVKLFTSHNN MTNYATVWAS KTNLEQRKGR
AGRVRPGFCF HLCSRARFDK LETHMTPEIF RTPLHEIALS IKLLRLGGIG HFLSKAIEPP
PLDAVIEAEH TLKELDALDS NDELTPLGRI LARLPIEPRL GKMMIMGCIF HVGDAMCTIS
AASCFPEPFI NEGKRLGFVH RNFAGSRFSD HVALLSVFQA WDDVRINGEE AESRFCDHKR
LNMSTLRMTW EAKVQLKEIL VNSGFPEECL MTQMFNTVGP DNNLDVVVSL LTFGSYPNVC
YHKEKRKILT TEGRNALIHK SSVNCPFSSH DMIYPSPFFV FGEKIRTRAI SAKAMTLVSP
LQLLLFACKK VTSNGEIVEL DDWIKLTIAH EVAGNILALR ASLEAVVVEV TKDPEYIRQM
DQTNERLLNV IRHVSKPSAA RLNMMVTNQR MGDGPRPPKM PRFDGGGGGR GYQGGGGYRG
GYGGGGGGYR GGGGYGGGGG YRGGGGYGGY RGGGGYGGGG GGYRGGGGGG GGGYRGGGGG
YRGGGGYRGG Y
//
