ID A0A3Q2WF62_HAPBU Unreviewed; 417 AA.
AC A0A3Q2WF62;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Cytohesin-2 {ECO:0000256|ARBA:ARBA00040245};
DE AltName: Full=PH, SEC7 and coiled-coil domain-containing protein 2 {ECO:0000256|ARBA:ARBA00042728};
GN Name=CYTH2 {ECO:0000313|Ensembl:ENSHBUP00000024011.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000024011.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000024011.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR AlphaFoldDB; A0A3Q2WF62; -.
DR STRING; 8153.ENSHBUP00000024011; -.
DR Ensembl; ENSHBUT00000009624.1; ENSHBUP00000024011.1; ENSHBUG00000005183.1.
DR GeneTree; ENSGT00940000160074; -.
DR OMA; GASHWRA; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF343; CYTOHESIN-2; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 71..258
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 276..393
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 35..69
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 417 AA; 48500 MW; A93F924EA1249D03 CRC64;
MTFDSELFMP KSKAPKMDDL DYIPVDLSPE ERSELEDIRR RKGVLLQEIQ RLREELREAI
LEVEGLETST EGSKTLQKSR HVAMGRKKFN MDPKKGIAFL VENELLRHTP EDIAQFLYKG
EGLNKTAIGD YLGERDDFNI KVLQAFVDLH EFTDLNLVQA LRQFLWSFRL PGEAQKIDRM
MEAFAQRYCH CNPGVFQSTD TCYVLSFAII MLNTSLHNPN VRDKPGVDRF ISMNRGINEG
GDLPEELLRN LYESIKNEPF KIPEDDGNDL THTFFNPDRE GWLLKLAGGR VKTWKRRWFI
LTDNCLYYFE YTTDKEPRGI IPLENLSIRE VEDPRKPNCF ELYIPNNRGQ LIKACKTEAD
GRVVEGNHMV YRISAPTPEE KDEWIHSIKS AVSVDPFYEM LAARKKRISL KKKEEQP
//