GenomeNet

Database: UniProt
Entry: A0A3Q2WF62_HAPBU
LinkDB: A0A3Q2WF62_HAPBU
Original site: A0A3Q2WF62_HAPBU 
ID   A0A3Q2WF62_HAPBU        Unreviewed;       417 AA.
AC   A0A3Q2WF62;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Cytohesin-2 {ECO:0000256|ARBA:ARBA00040245};
DE   AltName: Full=PH, SEC7 and coiled-coil domain-containing protein 2 {ECO:0000256|ARBA:ARBA00042728};
GN   Name=CYTH2 {ECO:0000313|Ensembl:ENSHBUP00000024011.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000024011.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000024011.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q2WF62; -.
DR   STRING; 8153.ENSHBUP00000024011; -.
DR   Ensembl; ENSHBUT00000009624.1; ENSHBUP00000024011.1; ENSHBUG00000005183.1.
DR   GeneTree; ENSGT00940000160074; -.
DR   OMA; GASHWRA; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd01252; PH_GRP1-like; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663:SF343; CYTOHESIN-2; 1.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT   DOMAIN          71..258
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   DOMAIN          276..393
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   COILED          35..69
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   417 AA;  48500 MW;  A93F924EA1249D03 CRC64;
     MTFDSELFMP KSKAPKMDDL DYIPVDLSPE ERSELEDIRR RKGVLLQEIQ RLREELREAI
     LEVEGLETST EGSKTLQKSR HVAMGRKKFN MDPKKGIAFL VENELLRHTP EDIAQFLYKG
     EGLNKTAIGD YLGERDDFNI KVLQAFVDLH EFTDLNLVQA LRQFLWSFRL PGEAQKIDRM
     MEAFAQRYCH CNPGVFQSTD TCYVLSFAII MLNTSLHNPN VRDKPGVDRF ISMNRGINEG
     GDLPEELLRN LYESIKNEPF KIPEDDGNDL THTFFNPDRE GWLLKLAGGR VKTWKRRWFI
     LTDNCLYYFE YTTDKEPRGI IPLENLSIRE VEDPRKPNCF ELYIPNNRGQ LIKACKTEAD
     GRVVEGNHMV YRISAPTPEE KDEWIHSIKS AVSVDPFYEM LAARKKRISL KKKEEQP
//
DBGET integrated database retrieval system