ID A0A3Q2WF91_HAPBU Unreviewed; 1068 AA.
AC A0A3Q2WF91;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Pleckstrin homology and RUN domain containing M1 {ECO:0000313|Ensembl:ENSHBUP00000024673.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000024673.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000024673.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005913675.1; XM_005913613.2.
DR RefSeq; XP_005913676.1; XM_005913614.2.
DR STRING; 8153.ENSHBUP00000004889; -.
DR Ensembl; ENSHBUT00000007929.1; ENSHBUP00000004889.1; ENSHBUG00000006225.1.
DR Ensembl; ENSHBUT00000007942.1; ENSHBUP00000024673.1; ENSHBUG00000006225.1.
DR GeneID; 102291052; -.
DR CTD; 9842; -.
DR GeneTree; ENSGT00940000155111; -.
DR OMA; HVLNCDL; -.
DR OrthoDB; 126314at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR CDD; cd00821; PH; 1.
DR CDD; cd17679; RUN_PLEKHM1; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047326; RUN_PLEKHM1.
DR PANTHER; PTHR12326; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12326:SF5; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50826; RUN; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 41..182
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 530..621
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 692..789
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 267..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1068 AA; 119545 MW; C6C9B053EFC065C0 CRC64;
MLATQTEAHH ETKDVKKIKE KLAQSLKALQ KRYVASDSVV TSDDSDANLL CCALEAIFIH
GIKSKYIRSE SRSSSRKGDR GPLPQPFFWS LLKSVTHRDV ITELEKISFV GTDVGRCRAW
LRLALNHGLL ECYLVSLFRE DSKLQAHYQP SALLLNPEER EVLLSYLQGL ASLTFSLSYK
SSVLNEWTTT PLALAGLCPL SQADLLDLPL NGGDPPTSKP IWKEIWDTVS QSSGSSDALD
VQRGCPVLVG RGSDLLQGSQ TALRSSNLSL DTTGSSQLSS SLSSDSLLQG QDPRSPTGEH
WSSCDLEAAI NPNICTKRPQ KDSLTDFRES GHCSQDSTQE DSFVSSMGPS QFSEKGIISD
SEPQASEYQP PNFGQLDLEQ PETTTELQSS DDDKCPAEVC KSASSELHSD ICLVSAVSEP
AEPVEEVSVT VEPVQEEKPT ESSEKTNADS AVHQCPRRST SILSRKPSSD SLSHSYSWIS
DDDIYKPHLE NLPDSDDAPV SPPAPEPSIS PSRPSVVHRR QIGLSNPFRG LLKLGHLERR
SAVGLWRDYY CELSPFEFRL YGNADERTCC ENCSLVRCED VHITSTDGRF DLTFPGKRLY
LRAANRDEAE DWVDRIIEAV NKSRPVPHGE QWEVLHTGCE NGVDERAVSS PPLSPSSPEQ
GPSGSDACGG QDSPSPPQQE FDWTSTTNLE TDSIKEAVLY FSTDPEARTW ERMVFSLSLE
TLKGFLVKEG RKLQRLNYPV EEIRDVVPDV SQGGPAFFKL LTIRETLRFR AENDKEARFW
RKFIREALDS YLENGECEGS EVPLEATGNL YRLVQHRLKE DGALLVHLFK VPSEKGLDTQ
GFKCAGCPQK IGLSLGRARL CEFSGLYYCE SCHKGDTSII PSRMVHNWDV AQREVSKKAL
WLLKQVEQEP LLNLEQLNPE LVAHTESMGQ AHEQRQKLCL LGEYLRTCRS GACKKLQARM
GQRTYLLESN HLYSVKDLRQ VAEGQYVNFL RRLVQHASNH VFSCDLCTQR GYICQICHSD
DTIFPFQFET TTRCEDCKAL FHISCKADEQ SCPRCQRMRK YMERDLQD
//
