ID A0A3Q2WH03_HAPBU Unreviewed; 1522 AA.
AC A0A3Q2WH03;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRD {ECO:0000313|Ensembl:ENSHBUP00000024485.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000024485.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000024485.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR RefSeq; XP_005935280.1; XM_005935218.2.
DR Ensembl; ENSHBUT00000008463.1; ENSHBUP00000024485.1; ENSHBUG00000005922.1.
DR GeneID; 102302568; -.
DR GeneTree; ENSGT00940000153617; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14624; R-PTPc-D-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR045905; R-PTP-delta_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..1522
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018699461"
FT TRANSMEM 873..896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..127
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 139..237
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 249..331
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 338..428
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 433..529
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 531..624
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 626..712
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 967..1222
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1142..1213
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1254..1513
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1431..1504
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 418..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1522 AA; 171597 MW; 337623EB29AE427D CRC64;
MLVPSCPTMR RARPTLLLPL LLVLGLLLHL ADAQTPPKFL RTPNDQTGVQ GGVASFICQA
TGDPRPKIVW NKKGKKVSNQ RFEVIEFDDG SGSVLRIQPL RTPRDEAIYE CVASNSVGET
SATTRLTVLR EDQLPPGFPT IDMGPQLKVV ERTRTATMLC AASGNPDPDI SWFKDFLPVN
TSNNNGRIKQ LRSESFGGTP IRGALQIEQS EESDQGKYEC VATNNDGTRY SAPANLYVRE
LREVRRVPPR FSIPPTDNEI MPGGSVNITC VAVGSPMPYV KWMMGAEDLT PEDDMPIGRN
VLELTDVRQS ANYTCVAMST LGVIEAAAQI TVKALPKAPG IPVVEERTAT SITLAWDSGN
PEPISYYIIQ HKSKYSDELY KEIDGVATTR YSVGGLSPYS DYEFRVVAVN NIGRGPPSES
IEAKTAEQAP STAPRQVRGH MMSATTAFIQ WDEPEEANGQ ITGYRVYYTM DPSQHPNHWE
KQIVRGSNIA TIQGLIPNKT YYIKILAYTS VGDGPLSPDL QIIAKTGVPS QPTDFKGEAK
SETSILLSWN AQTQTGQENQ VTGYELLYRK RDDKEEKRVS FEPTTTYLLK DLKPFTTYTF
RLAARSKHGV GAYTNEISAE TPQTLFAKNF HVKAAMKSSV LLTWEIPDTY NPAQPFTILY
DNGQSVEVDG KLTQKLITGL QPETQYSFLL TNRGNSAGGL QHRVSTMTAP DVLRTKPYLV
DKTNSDGMVT VELPAVETSE RVRGYYIVVV PLKKQRTGKF FKPWDSPDEM NLEELLKEIN
RTSRGLRFQR QAEPKAYIAA YFKDLPKQFT LGDGKIYGDF ENKQLQNGQE YIFFVLAVLE
MSENIMYATS PYSDSVVSAD IDPQPIIDEE EGLIWVVGPV LAVVFIICIV IAILLYKSKP
DRKRAESEAR KGSLPNSKEM PLHHPTDPVE LRRLNFQTPG MASHPPIPVM ELADHLERLK
ANDNLKFSQE YESIDPGQQF TWEHSNLEVN KPKNRYANVI AYDHSRVLLS AIDGIPGSDY
INSNYIDGYR KQNAYIATQG SLPETFGDFW RMLWEQRSAT IVMMTKLEER SRVKCDQYWP
TRGTETYGLI QVTLLDTVEL ATYCVRTFAL FKNGSSEKRE VRQFQFTAWP DHGVPEHPTP
FLAFLRRVKA CNPPDAGPMV VHCSAGVGRT GCFIVIDAML ERIKHEKTVD IYGHVTLMRA
QRNYMVQTED QYVFIHDALQ EAVNCGTTEV PARNLYAYIQ KLTQIEGGEN VTGMELEFKR
LANTKAHTSR FISANLPCNK FKNRLVNIMP YESTRVCLQP IRGVEGSDYI NASFIDGYRQ
QKAYIATQGP LAETTEDFWR MLWEHNSTIV VMLTKLREMG REKCHQYWPA ERSARYQYFV
VDPMAEYNMP QYILREFKVT DARDGQSRTV RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT
KEQFGQDGPI SVHCSAGVGR TGVFITLSIV LERMRYEGVV DIFQTVKMLR TQRPAMVQTE
DQYQFCYRAG LEYLGSFDHY AT
//
