ID A0A3Q2WH09_HAPBU Unreviewed; 432 AA.
AC A0A3Q2WH09;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Eukaryotic translation initiation factor 5 {ECO:0000256|ARBA:ARBA00018059};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000021049.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000021049.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family.
CC {ECO:0000256|ARBA:ARBA00010397}.
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DR RefSeq; XP_014196183.1; XM_014340697.1.
DR RefSeq; XP_014196184.1; XM_014340698.1.
DR RefSeq; XP_014196185.1; XM_014340699.1.
DR AlphaFoldDB; A0A3Q2WH09; -.
DR STRING; 8153.ENSHBUP00000021049; -.
DR Ensembl; ENSHBUT00000030819.1; ENSHBUP00000021049.1; ENSHBUG00000001036.1.
DR GeneID; 102296143; -.
DR CTD; 1983; -.
DR GeneTree; ENSGT00390000016478; -.
DR OMA; YRYKMEK; -.
DR OrthoDB; 5475947at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11561; W2_eIF5; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.20.25.350; -; 1.
DR Gene3D; 3.30.30.170; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045196; IF2/IF5.
DR InterPro; IPR002735; Transl_init_fac_IF2/IF5_dom.
DR InterPro; IPR016189; Transl_init_fac_IF2/IF5_N.
DR InterPro; IPR016190; Transl_init_fac_IF2/IF5_Zn-bd.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23001; EUKARYOTIC TRANSLATION INITIATION FACTOR; 1.
DR PANTHER; PTHR23001:SF7; EUKARYOTIC TRANSLATION INITIATION FACTOR 5; 1.
DR Pfam; PF01873; eIF-5_eIF-2B; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00653; eIF2B_5; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF100966; Translation initiation factor 2 beta, aIF2beta, N-terminal domain; 1.
DR SUPFAM; SSF75689; Zinc-binding domain of translation initiation factor 2 beta; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT DOMAIN 229..388
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 142..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..400
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 49276 MW; 83D7F4D889C2946B CRC64;
MSVNVNRSVS DQFYRYKMPR LIAKVEGKGN GIKTVIVNMV DVAKALNRPP TYPTKFFGCE
LGAQTQFDTK NDRYIVNGSH EANKLQDMLD GFIRKFVLCA ECDNPETDLH VNPKKQTIGT
SCKACGYRGM LDTRHKLCTF ILKNPPESND SGSASVKKEK EKKNRKKDKE NGSGSGEAGN
HDNFDAPEAV DRDDDDEDWA EETTEEAQRR RMEEISDHAK NLTLSEDLEK PLEDRVNLFY
SFVKNKKESG TIDAADKEIL AEAERLDVKA MGPLILSELL FNENIRDQIK KYKRHFLRFC
HNNKKAQKYL LGGFECVVKL HQVQLLPRVP IILKDLYDAD LLEEDVIFAW AEKVSKKYVS
KELAKEIHAK AAPFVKWLKE AEEESEGSEE EEEEDDENVE VVYSSSAREL KVETVKPDTP
EKEEDDIDID AI
//
