ID A0A3Q2WH46_HAPBU Unreviewed; 378 AA.
AC A0A3Q2WH46;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000025468.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000025468.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005914689.1; XM_005914627.2.
DR RefSeq; XP_005914690.1; XM_005914628.2.
DR RefSeq; XP_005914691.1; XM_005914629.2.
DR AlphaFoldDB; A0A3Q2WH46; -.
DR STRING; 8153.ENSHBUP00000025468; -.
DR Ensembl; ENSHBUT00000005887.1; ENSHBUP00000025468.1; ENSHBUG00000000778.1.
DR GeneID; 102306465; -.
DR CTD; 7474; -.
DR GeneTree; ENSGT00940000158894; -.
DR OMA; LVERCNC; -.
DR OrthoDB; 2874082at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF33; PROTEIN WNT-5A; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
SQ SEQUENCE 378 AA; 42527 MW; 9CA6E549A9429CE6 CRC64;
MNLGLGCVRR PICWPFGSVL DSRHCVFALT LLTLLMQVVV EANSWWSLAM NPLLIPEAYI
IGAQPLCSQL VGLSQGQKKL CQLYQDHMQY IGEGAKTGIR ECQYQFRHRR WNCSTVDNSS
VFGRVMQIGS RETAFTYAIS AAGVVNAVSR ACREGELSSC GCSRAARPKD LPRDWLWGGC
GDNLNYGYRF SREFVDARER EKSFPKGSHE NARLLMNLHN NEAGRRIVSD LAHVSCKCHG
VSGSCSLKTC WLQLADFRKV GDALKEKYDS AVAMKLNSRG KLVQMHSRFN PPTNHDLVYI
EQSPDYCLKN QSTGSLGTVG RLCNKTSEGM DGCELMCCGR GYDQYKAQIV ERCHCKFHWC
CYVKCKRCTK VVDQFVCK
//
