ID A0A3Q2WHP1_HAPBU Unreviewed; 684 AA.
AC A0A3Q2WHP1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=T-box transcription factor 2 {ECO:0000313|Ensembl:ENSHBUP00000024765.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000024765.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000024765.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR RefSeq; XP_005930918.1; XM_005930856.1.
DR AlphaFoldDB; A0A3Q2WHP1; -.
DR STRING; 8153.ENSHBUP00000024765; -.
DR Ensembl; ENSHBUT00000007742.1; ENSHBUP00000024765.1; ENSHBUG00000006339.1.
DR GeneID; 102309032; -.
DR CTD; 30253; -.
DR GeneTree; ENSGT00940000158439; -.
DR OMA; EQCKPER; -.
DR OrthoDB; 5323209at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0036302; P:atrioventricular canal development; IEA:Ensembl.
DR GO; GO:0048318; P:axial mesoderm development; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0003205; P:cardiac chamber development; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl.
DR GO; GO:0042074; P:cell migration involved in gastrulation; IEA:Ensembl.
DR GO; GO:0021538; P:epithalamus development; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0070365; P:hepatocyte differentiation; IEA:Ensembl.
DR GO; GO:0072068; P:late distal convoluted tubule development; IEA:Ensembl.
DR GO; GO:0030903; P:notochord development; IEA:Ensembl.
DR GO; GO:0043704; P:photoreceptor cell fate specification; IEA:Ensembl.
DR GO; GO:0021982; P:pineal gland development; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0035777; P:pronephric distal tubule development; IEA:Ensembl.
DR GO; GO:0072019; P:proximal convoluted tubule development; IEA:Ensembl.
DR GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR GO; GO:0046549; P:retinal cone cell development; IEA:Ensembl.
DR GO; GO:0042671; P:retinal cone cell fate determination; IEA:Ensembl.
DR GO; GO:0046548; P:retinal rod cell development; IEA:Ensembl.
DR CDD; cd20188; T-box_TBX2_3-like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR022582; TBX2/3_TAD.
DR InterPro; IPR048387; TBX2_3_RD.
DR InterPro; IPR002070; TF_Brachyury.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF82; T-BOX TRANSCRIPTION FACTOR TBX2; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF12598; TBX; 1.
DR Pfam; PF20627; TBX2-3_RD; 1.
DR PRINTS; PR00938; BRACHYURY.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 97..275
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 268..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 74717 MW; 556F449DE64F2D11 CRC64;
MRDPVFTGTA MAYHPFHAHR PTDFPMSAFL AAAQPSFFPA LSLPPGALTK PITDHGLAGA
AEAGLHPALS HHQAAHLRSM KSLEPEEEVD DDPKVTLEAK DLWDQFHKLG TEMVITKSGR
RMFPPFKVRI NGLDKKAKYI LLMDIVAADD CRYKFHNSRW MVAGKADPEM PKRMYIHPDS
PATGEQWMAK PVAFHKLKLT NNISDKHGFT ILNSMHKYQP RFHIVRANDI LKLPYSTFRT
YVFPETEFVA VTAYQNDKIT QLKIDNNPFA KGFRDTGNGR REKRKQLSMP SLRMYEDQCK
ADREGADSDA SSSEAPAGRD TVHSPLGAGT SPLRFSRPSR DDKTCTDSEQ ELEHQDERCT
GSNSPGPEPV SPYSSRCEER MRERAVAEKK DDSLFSIRSL EKDKVESRHR KDTTDVLTKD
SEAGGISATK DAFSPLVVQT ESPSHFSPGH LQSLALSGLH SQQFFNPLNT GSPLLFHPGQ
FAMAPGAFSA MGMGHLLASV SGTSGLENGS LSTQGTGGTP NPFPFHLSQH MLASQGIPMP
PFGGLFPYPY TYMAAAAAAA SASALPATST SSPLSRNPFL GSSRPRLRFN PYQLPVSLPQ
SSSLLTTSLQ GSINPGSESS KPGSRETSPA PEHHSNHKTG GSSGRVTSPK TSVKDSVNEL
QSIQRLVSGL EGQREPSPNT DCPK
//
