ID A0A3Q2WNC8_HAPBU Unreviewed; 301 AA.
AC A0A3Q2WNC8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000023614.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000023614.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-
CC bisphosphate + H(+) + thyroxine sulfate; Xref=Rhea:RHEA:26422,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343,
CC ChEBI:CHEBI:58910, ChEBI:CHEBI:305790; EC=2.8.2.n2;
CC Evidence={ECO:0000256|ARBA:ARBA00036007};
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|ARBA:ARBA00005771, ECO:0000256|RuleBase:RU361155}.
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DR RefSeq; XP_005937096.1; XM_005937034.2.
DR AlphaFoldDB; A0A3Q2WNC8; -.
DR STRING; 8153.ENSHBUP00000023614; -.
DR Ensembl; ENSHBUT00000010672.1; ENSHBUP00000023614.1; ENSHBUG00000004506.1.
DR GeneID; 102296435; -.
DR CTD; 391365; -.
DR GeneTree; ENSGT00940000159084; -.
DR OMA; FMSGEVC; -.
DR OrthoDB; 3083090at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:Ensembl.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR11783:SF341; SULFOTRANSFERASE 6B1; 1.
DR PANTHER; PTHR11783; SULFOTRANSFERASE SULT; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361155}.
FT DOMAIN 55..288
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
SQ SEQUENCE 301 AA; 34167 MW; BDA88B42202121F1 CRC64;
MSGEGPMGPL QAKMLKAKEM SNEEKVYRYN GVLYLTVLSP EEHLKCLEKM QAREDDIMLV
AYPKCGFNWM VGVIKKIITA ATGVKSESKL PPLIEFHGPE NLKNVEEAPS PRLLGAHLHP
DNIPASFYEK KTKILVVFRN PKDTMVSFYH FSNSNPALPS AKSWDTFYSQ FMSGEVPWGS
YFDHALGWEK KMDDPNVMVV TYEELKQDLS ENIRRISSFY GFSLTEAQVQ QIADASTFKA
MKESSSSSHG NMGNVFFRKG EVGDWKNYFT PEQSREMDEV FNKRLAGTKI GAKLNYQAHC
Q
//
