ID A0A3Q2WQ61_HAPBU Unreviewed; 461 AA.
AC A0A3Q2WQ61;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Clusterin {ECO:0000256|ARBA:ARBA00020334, ECO:0000256|RuleBase:RU000629};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000028181.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000028181.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, secretory
CC vesicle, chromaffin granule {ECO:0000256|ARBA:ARBA00004248}.
CC Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004346}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004346}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004346}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the clusterin family.
CC {ECO:0000256|ARBA:ARBA00010069, ECO:0000256|RuleBase:RU000629}.
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DR RefSeq; XP_005931597.1; XM_005931535.1.
DR AlphaFoldDB; A0A3Q2WQ61; -.
DR Ensembl; ENSHBUT00000017083.1; ENSHBUP00000028181.1; ENSHBUG00000011798.1.
DR GeneID; 102311610; -.
DR CTD; 1191; -.
DR GeneTree; ENSGT00530000063668; -.
DR OrthoDB; 4321242at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0042583; C:chromaffin granule; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR000753; Clusterin-like.
DR InterPro; IPR016015; Clusterin_C.
DR InterPro; IPR033986; Clusterin_CS.
DR InterPro; IPR016014; Clusterin_N.
DR PANTHER; PTHR10970; CLUSTERIN; 1.
DR PANTHER; PTHR10970:SF1; CLUSTERIN; 1.
DR Pfam; PF01093; Clusterin; 1.
DR SMART; SM00035; CLa; 1.
DR SMART; SM00030; CLb; 1.
DR PROSITE; PS00492; CLUSTERIN_1; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..461
FT /note="Clusterin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018782578"
FT DOMAIN 34..229
FT /note="Clusterin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00030"
FT DOMAIN 230..454
FT /note="Clusterin C-terminal"
FT /evidence="ECO:0000259|SMART:SM00035"
FT COILED 67..115
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 461 AA; 52749 MW; 273166C9EF03F9FC CRC64;
MLMMMMMMKR KGSKESLTLV ALLVASASCI LPPTKEDLNQ ISIQGEKYLD RQIENAINGV
KEMKSVMQKS SEEHKRFLDD LEKTEQKKEE AMRTAQEMEA KLEKEEEVCN ETMKALWEEC
KPCLKNTCVK YYSRTCSSGS GLVGRQLEEV LNRTSPFSIW INGEKIDILE QEGQRQNREF
KNLEEKYTEM ADGVDNIFTD SMKVADYVHY SPPVIYLPNF LSPYARRGRS IRSLFHDPFH
GFQNLFSPMM GMSRNFFSSM GSMMDMDSDT VPNEDGNVNE DVIITKPYGN GRMTCREIRR
NSAGCFKFRD ECQKCKEIQH IDCSGKKPLE GPLKEELEEA LALAERFTQQ YNSLLKRFEE
QMLNTSSILD LFNSQFGWVS SLANNTSDGI FSVQAVMCKD SEKKVDGEEE PGETKVSVKL
FDSPSMNFTV PGEIPWNDPK FSEVVAQEAL DRYKETSVVV K
//
