ID A0A3Q2WRF2_HAPBU Unreviewed; 185 AA.
AC A0A3Q2WRF2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Erythropoietin {ECO:0000256|ARBA:ARBA00015421, ECO:0000256|PIRNR:PIRNR001951};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000028300.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000028300.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Erythropoietin is the principal hormone involved in the
CC regulation of erythrocyte differentiation and the maintenance of a
CC physiological level of circulating erythrocyte mass.
CC {ECO:0000256|PIRNR:PIRNR001951}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR001951}.
CC -!- SIMILARITY: Belongs to the EPO/TPO family.
CC {ECO:0000256|ARBA:ARBA00005782, ECO:0000256|PIRNR:PIRNR001951}.
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DR RefSeq; XP_005939243.1; XM_005939181.2.
DR AlphaFoldDB; A0A3Q2WRF2; -.
DR STRING; 8153.ENSHBUP00000028300; -.
DR Ensembl; ENSHBUT00000017313.1; ENSHBUP00000028300.1; ENSHBUG00000011982.1.
DR GeneID; 102311730; -.
DR CTD; 100004455; -.
DR GeneTree; ENSGT00390000017226; -.
DR OMA; AMEFPRL; -.
DR OrthoDB; 4338688at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005128; F:erythropoietin receptor binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-UniRule.
DR GO; GO:0048823; P:nucleate erythrocyte development; IEA:Ensembl.
DR GO; GO:0048793; P:pronephros development; IEA:Ensembl.
DR GO; GO:0014823; P:response to activity; IEA:Ensembl.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001323; EPO_TPO.
DR InterPro; IPR003013; Erythroptn.
DR PANTHER; PTHR10370; ERYTHROPOIETIN; 1.
DR PANTHER; PTHR10370:SF0; ERYTHROPOIETIN; 1.
DR Pfam; PF00758; EPO_TPO; 1.
DR PIRSF; PIRSF001951; EPO; 1.
DR PRINTS; PR00272; ERYTHROPTN.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001951-1};
KW Erythrocyte maturation {ECO:0000256|ARBA:ARBA00023057,
KW ECO:0000256|PIRNR:PIRNR001951}; Hormone {ECO:0000256|PIRNR:PIRNR001951};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Secreted {ECO:0000256|PIRNR:PIRNR001951}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..185
FT /note="Erythropoietin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018704487"
FT DISULFID 32..180
FT /evidence="ECO:0000256|PIRSR:PIRSR001951-1"
FT DISULFID 54..58
FT /evidence="ECO:0000256|PIRSR:PIRSR001951-1"
SQ SEQUENCE 185 AA; 20464 MW; DE0DB911B38683E4 CRC64;
MLQKTGRGLL ALLLLVLDWT QPGLSSPLRP ICDLRVLNHF IQEARDAEGA MKSCREGCGL
SQSVTVPQTT VDFDVWEKKN AQEQAQEVQT GLWLLQQSLN TLQTSVTNTA MHSHIDNTIR
NLLSINAVLR SLNIQEFTPP ANATDLEGTW RVSLATDLLQ VHVNFLRGKV HLLLSSAQAC
KPDVS
//
