ID A0A3Q2WRP2_HAPBU Unreviewed; 360 AA.
AC A0A3Q2WRP2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Perforin 1.2 {ECO:0008006|Google:ProtNLM};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000028786.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000028786.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
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DR AlphaFoldDB; A0A3Q2WRP2; -.
DR STRING; 8153.ENSHBUP00000028786; -.
DR Ensembl; ENSHBUT00000031995.1; ENSHBUP00000028786.1; ENSHBUG00000012773.1.
DR GeneTree; ENSGT00530000063725; -.
DR OMA; HKACEAN; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR46096:SF5; PERFORIN 1.3-RELATED; 1.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00239; C2; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 14..360
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 185..301
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 360 AA; 40020 MW; 36801AD6DAC58903 CRC64;
IPLCLPSSVS FIGTPQECEK AHFVPGYNLG GEGFDIVTME RKGAYVIDTE TWKIGNGNCR
MYCNRYMNGE KQKVPVAVVD WRTLPKCSLK VSSVVYDSVE TLVSDSTSSV SNNWTIGLDV
PVDPSAKVGV GLGGSHSRDS TFAMKKSKQD RYTFLHHSIN CKFYGYRLAT SPPLSQEFKS
ALDIPPYSSK TAPLYHNLID TYGTHYITQV SLGGEIKATT ATDGSVEVTY GDQKKRTDII
SNDDNPRWRE TFEFGTITIN MKNKLKFSVY DEDSYWNSDL LGECSFDLRA GKVSDSCMLN
HGTFFFSYIV ECAPSLSGNQ CQEYIPSAMS PSLAEVFHTR NGVLLGKMGN KYEKPANERL
//
