ID A0A3Q2WSA3_HAPBU Unreviewed; 930 AA.
AC A0A3Q2WSA3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Complement component C6 {ECO:0000256|ARBA:ARBA00018265};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000028640.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000028640.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Constituent of the membrane attack complex (MAC) that plays a
CC key role in the innate and adaptive immune response by forming pores in
CC the plasma membrane of target cells. {ECO:0000256|ARBA:ARBA00002409}.
CC -!- SUBUNIT: Component of the membrane attack complex (MAC). MAC assembly
CC is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds
CC sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit
CC C9. {ECO:0000256|ARBA:ARBA00025836}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR AlphaFoldDB; A0A3Q2WSA3; -.
DR STRING; 8153.ENSHBUP00000028640; -.
DR Ensembl; ENSHBUT00000017991.1; ENSHBUP00000028640.1; ENSHBUG00000012538.1.
DR GeneTree; ENSGT00940000156804; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 3.30.60.30; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR048825; C7_KAZAL.
DR InterPro; IPR048831; C8A_B_C6_EGF-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR040729; Kazal_3.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF2; COMPLEMENT COMPONENT C7; 1.
DR Pfam; PF21330; C7_KAZAL; 1.
DR Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR Pfam; PF18434; Kazal_3; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00084; Sushi; 2.
DR Pfam; PF00090; TSP_1; 2.
DR PRINTS; PR00764; COMPLEMENTC9.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00057; FIMAC; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50923; SUSHI; 2.
DR PROSITE; PS50092; TSP1; 2.
PE 3: Inferred from homology;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 225..544
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 657..716
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 717..779
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 879..930
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DISULFID 193..211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 205..220
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 687..714
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 719..762
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 930 AA; 103057 MW; 49D358AEF151F626 CRC64;
MTSGLSLLRA VMVFMLLLFL YLFTECGMSW QRCRRTPRCV SVGSSCDVFT LWRSKEWRHL
PVESENSRKT VRRRLPDTLL AGYMSLSAIV LVQRRRLNSE EHIMKLNLAA ALALSLAFIS
PVCCQQPVNC RWGPYGDWSE CDGCTSTKVR TRHVEVFAQF GGVPCSGEAT QTQTCVPQKR
CPLEAGCGDR FRCTSGQCIS QSLVCNGDQD CEDGLDERNC GEDNSLATCD LDKTPPNSDF
TGRGYDVLTG KLRAGVINTR SFGGQCRKVF SGDHKVLYRL PHNILRYNFE VTVDNDESDE
SYESSWSYMQ HIQSNAFLVH DRRTFHKEVT NNKAYRLIIL KNKVELAQFQ NSAPQYLTLA
EGFWKALSLL PLTYDYSAYH QVLQKYGTHY LSEGSLGGEY QALLELDRQA LASTSTTDID
YQRCWRKVKR RFFRKKVKTV CEKLTKSVSS SHGSSVNKMP IKVNVFGGDI GLIGALSVLD
LENPEANGEV YDNWASSVKD FPEVINQKLR PLYELVKEVQ CAGLKKLHLK RATEEYLAEE
HPCHCQPCQN NGQPLLTGSE CRCVCRPGTS GRACENGAVI GEQPGVIHGS WSCWSSWGSC
SGGQRSRTRS CNNPAPSRGG QHCTGLQVEQ KPCDDPDIQY LQMMEPQCFS LSVTPPKTCG
PPPNLRNGFV QNPRDFYLVG NTVEYSCVDW YYLSGNAVAT CAENQKWTTG TRVCKSSTCG
IPSLNNLVVA TPTKQAYEIG DSVSLSCPEG SVIDREVSEI ICTPSLQWSP SPAVAHCTAA
PTAPSPPSGL TCKLWETLGK NECVCKMPNQ CTTSLQLCAT LRANRNMVLD VCKLGALRCM
GRNFVLTSDS DCRWPEKKFT SCEDCQPGTI CQEAERKCVC RNASECPKDS TPLCVSSGDG
STHVTTTECE AGARRCAGEQ VNVISIDPCQ
//
