ID A0A3Q2WT47_HAPBU Unreviewed; 3836 AA.
AC A0A3Q2WT47;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Zinc finger homeobox 3 {ECO:0000313|Ensembl:ENSHBUP00000028975.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000028975.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000028975.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR Ensembl; ENSHBUT00000018639.1; ENSHBUP00000028975.1; ENSHBUG00000013200.1.
DR GeneTree; ENSGT00940000156149; -.
DR OMA; SVCNKFS; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00086; homeodomain; 4.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR Gene3D; 1.10.10.60; Homeodomain-like; 4.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45891; ZINC FINGER HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR45891:SF4; ZINC FINGER HOMEOBOX PROTEIN 3; 1.
DR Pfam; PF00046; Homeodomain; 4.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00389; HOX; 4.
DR SMART; SM00355; ZnF_C2H2; 22.
DR SMART; SM00451; ZnF_U1; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR SUPFAM; SSF46689; Homeodomain-like; 4.
DR PROSITE; PS00027; HOMEOBOX_1; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 823..852
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1487..1517
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1528..1550
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1673..1704
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1724..1753
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 2125..2153
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 2285..2345
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 2382..2442
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 2471..2500
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 2668..2690
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 2776..2836
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 2848..2878
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 3075..3135
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 2287..2346
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 2384..2443
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 2778..2837
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 3077..3136
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1258..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1422..1460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1602..1663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1765..1844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2003..2068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2171..2229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2345..2386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2439..2458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2520..2573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2592..2652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2732..2783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2903..2938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2978..3025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3048..3081
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3271..3404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3508..3561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3673..3836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..127
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..183
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..704
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..905
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1277..1293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1312..1331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1433..1447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1765..1836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2009..2051
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2176..2204
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2213..2229
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2349..2366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2367..2386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2441..2458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2520..2568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2600..2614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2615..2652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2732..2750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2903..2927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3048..3065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3290..3344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3345..3368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3369..3389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3508..3528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3675..3694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3708..3732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3748..3790
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3813..3836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3836 AA; 419254 MW; 8120DD73F95AB8B1 CRC64;
MDSCESPVVS GTDDGLGSSQ QQQPPQPWND HNSSQVTCTN QAPSLDPLSL SGPYPSQSQN
SIAPHDRVRE LQSQQQQQPK QTSPRTHRDS SATGQLHPRG EGLDEEDQEG VSCGEEEESE
DLDEMEIDNC FPSLQPFPGM PIASGGGGMP TLLRHQPTQQ QGPPESGSEE GEEEEEEESS
DVENLAGEIV YQPDGSAYIV ESLSQLIQSS GGMVPGLLPT NSLSSGGKPG EPAGTSSSVY
PQIINTFHIA SSFGKWFGNS DQGFPNTSTM AGLSPVLHSF RVFDVRHKSN KDYLNSDGSA
KKSCVSKDVP NNVDFSKFDG LALYGKGKPI LMCFLCKLSF GYARSFATHA VHDHRMTLCE
DERRLLGDKH ASAIIQGIGK DKEPLISFLE PKNKSTPLPS TLLPLNSGQS FYGTFSGVHL
EPGSSSGGSE TLLNKDSDSG LQQQQQQQTP LGSVLSLGGL SIPKAPTLTS SPGSAKDSSA
LPKQGGRTEE PAGKELACKG EDGNTKGHES KAHLSSQTGG SEEDEELLLG AEEDEAESTA
MACGGNSSSG GGEAGEPAVS NQSISKSPLL MPSSTLQPSP CTSAVSSTLN SKALASISSS
VKEEGSTADG GGRTSELPLS FNCQGPTVPM ALVTAAVRRS EDETSGTSSS PLSTNAAPDE
SANRDSATAP EPNDCPAEGE EENGALLHHH HVHHHHHHLH PSSHGHSHPL PGGSCDITGM
GECSQNHGPS GSGVSGVECP KCDTVLGSSR SLGGHMTMMH SRNSCKTLKC PKCNWHYKYQ
QTLEAHMKEK HPDSGGSCVY CSSGQSHPRL ARGESYTCGY KPFRCEVCNY STTTKGNLSI
HMQSDKHLNN MQTLQNGGSI GSAQDQVFGH TPGGVVAVPS VTQASSHHPP HHHPSQSSTH
MSGPCGVPSP TKPKSKPSWR CEVCDYETNV ARNLRIHMTS EKHMHNMMLL QQNVTQMQHG
RLGLGAMPSP SEAELYQYYL TQNMSLPPSL KIDPAGAEAQ FLMGSFHLDP NMAALAPALV
GGEIPMDVRL GGGQLVSEEL MTLGESLSQT IDPSLKLFQC AVCNRFTTDN LDVLGMHMGA
ERSLPEEEWR AVVGDSHQCK LCHYTTQLKA NFQLHCKTDK HVQKYQLVAH IKEGGKGNEW
RLKCVAIGNP VHLKCNACDY YTNSLEKLRM HTVNSRHEAS LKLYKHLQQH ENAVEGDACY
YHCVLCNYST KAKLNLIQHV RSMKHQRSES LRKLQRLQKG LPEEEEDLSS IFTIRKCPSS
DTGELSEDVE AASETTTDQE DQTKDRESGG EKELTKGTAL SGHLERHQSG SPIPSKRPSS
RSEASESPLS SKRPRTAEKG AAEQMYQCPY CKFTNTDLNR LRMHVMTQHS VQPMLRCPLC
QDMLNNKIHL QFHLTHLHSV APDCVDKLIA TVTTTEALPA SMFIPVPSPD REPQSTPHAT
SNSNAEDTKK QADADPEKGV SLPTEIAEAR KSPLEDQQSE REDATGFLCW KKGCNQLFKT
SNSLQMHFNE VHNKRHQLPV SDRHVYKYRC NQCSLAFKTV EKLQLHSQYH VIRAATMCCL
CQRSFRTLQA LKKHLETSHL ELSEADIQQL YGGLLMNGDI MAMGDPSLGE EHGSLGEDDK
DGDESDPEEK QSPTGSDSGS LQEDSGSEPK RALPFRKGPN FTMEKFLDPS RPFKCTVCKE
SFTQKNILLV HYNSVSHLHK VKRALQESTT GQPEPTSSPD NKPFKCSTCN VAYSQSSTLE
IHMRSVLHQT KARAAKLEAA GGITSSASAT GLSSGGSGMS TSTSSPSPAS NSNTSSTNHS
SSGSQAAQNI LGGNHTSQTH NTENQGNSSV SCHSSPSENH EVKKSKFSDI LSARGQQQQQ
QLQQQQQLAQ AQAQAQAQLQ QELQQQAALL QSQLFNPALL QHFPMTTDAL LPLQQQQLLF
PFYIPGAEFQ LNPEISISSS ALGLAGSPSS LLEDLKNSAQ QSCLQQQLMH HHLQQQQQQQ
QQQQQQHQMA LLQQSASLLQ QAELKQKPPS SQNDKDREIQ RERHASEKNE DYVNKDSADS
RPKERESQHI SININHDTGL PPPRIASDAR GNATKALLEN FGFELVIQYN ENKQKAQKKT
AGPTGSSGPG GITRVIDPIG GLEKLECEAC GKLFSNILIL KSHQEHIHQA FFPFRSLERF
AKEYREHYDK LYPLRPPTPE AAPAPPPPPP PPPPPPPPQR APTPNIPVSN ASLTPPTVPP
PQAPVPMTQI PMPMDLPLFS PLMMQPMSLQ SLPTQLPPQL PSVEPSLASD LAQLYQQQLT
PAMLQQNKRP RTRITDDQLR VLRQYFDINN SPNEDQIKEM ADKSGLPQKV IKHWFRNTLF
KERQRNKDSP YNFNNPPTTT LEDTKIDSKP PSPEPQKHEY YGSKRSSRTR FTDYQLRVLQ
DFFDANAYPK DDEFEQLSNL LSLPTRVIVV WFQNARQKAR KNYENQGDGG KDGERRELSN
DRYIRTSNLN YQCKKCSLVF QRIFDLIKHQ KKLCYKDEDE DGQYDSQNED SMDFSHECYT
PSGSSCHTPM PSSSSLCPLP PTTSAFSHLP STEKEEASPA TTSNLYDEKP KQLPEITADP
RENQTSIKQE IVHQPQSEVQ HQRPQREDKI QNVSKPSKHS TPSFSQQQQQ SGLSASQTSQ
PSSQSSHMGL NPHLTSATQQ LAQQMIPYQC EQCKIGFPSF EHWQEHQQLH FLSVQNQFIH
PQFLDRPIDM SFMLFDPSNP LLATQLISGM PQIPSSSATS PSTPTSTMNS LKRKLEEKAS
TSPGENDSTN SGEEPQRDKR LRTTITPEQL EILYQKYLLD SNPTRKMLDH IAVEVGLKKR
VVQVWFQNTR ARERKGQFRA VGPAQAHRRC PFCRALFKAK TALEAHIRSR HWHEAKRAGY
NLTLSGMLPE QENMQIKMDA LDTSGYSQLP PTTNSDGQSS SMSPMNKGLD LSPRGLLSPS
SIKVEGMEDF ESATMSSMNL NFDQSKLDND DCSSVNTAIT DTTTGDEANA DNDSADAKHS
QNSGDYLSKS GGTAPILEND DQMSSGLVSP ATSYYAKDYE NENMIDHSET SSLADPCSPS
PGASGSRSLE GGDRPGQKRF RTQMTNLQLK VLKSCFNDYR TPTMLECEVL GNDIGLPKRV
VQVWFQNARA KEKKAKLNMA KHFGINQTSY EGPKTECTLC GVKYSARLSV RDHIFSQQHI
SKVKDTIGSQ IDKEKEYFDP ATVRQLMAQQ EMDRIKKANE VLGLAQQQAM QQQGMFDNPA
MQALNLQSAY PNLQGIPPVL LPGVGSPSLP SFNSSNSALT PPKPSNLLNM PGASVPSPSL
PTSGLPNKPP SSSSLTASSP AQTNTSTSHS NSTSNSTSST SQSRPEPPKE RDAERVKEKE
KAKEKTEKPS TPSSTGSTPA PSTSAASAKK EKPETAVPAT SMPTPGMEYV VDPAQLQALQ
AALASDPTAL LTNQFLPYFM PGFSPYYTPQ IPGALQGGYL QPMYGMESLF PYNPALSQAL
MGLSPGSLLQ HYQQYQQSLQ EALQQQQRQL QQIQQPKASQ TSVPPQTLGD RKDSAKDPAK
SEEQKGNPQI PSEQNEMDGK PVDTHLDQYI VPKVQYKLAC RKCQAVFTKE EAAITHLKSN
CFFGQSVANL QEMLLRVPGG VGVGAGSLYD CLACDTTLDG EKALSQHLES ALHKHRTIKR
SVRNAKEHAT SLLPHSSACF PNPNTASTSQ SATHPISSPP PPPTTSATMP SSAVSSSLCS
SSTTQLNTTA AGKPWPQAPF PRALAGKPNA SPSSSSSSFP PVSSPSTVTS SSLSTSGVQT
SIPTDVFTDE SDSDSSQKSA NRLGRTAEEP QQPGFVKDSN SCSSNLASVG TDSIRL
//
