ID A0A3Q2WT50_HAPBU Unreviewed; 1807 AA.
AC A0A3Q2WT50;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Tubby-related protein 4-like {ECO:0000313|Ensembl:ENSHBUP00000029381.1};
GN Name=TULP4 {ECO:0000313|Ensembl:ENSHBUP00000029381.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000029381.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000029381.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TUB family. {ECO:0000256|ARBA:ARBA00007129}.
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DR STRING; 8153.ENSHBUP00000029381; -.
DR Ensembl; ENSHBUT00000019427.1; ENSHBUP00000029381.1; ENSHBUG00000013811.1.
DR GeneTree; ENSGT00940000155913; -.
DR OMA; YAVHSIG; -.
DR Proteomes; UP000264840; Unplaced.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR025659; Tubby-like_C.
DR InterPro; IPR000007; Tubby_C.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR16517; TUBBY-RELATED; 1.
DR PANTHER; PTHR16517:SF115; TUBBY-RELATED PROTEIN 4; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF01167; Tub; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR SUPFAM; SSF54518; Tubby C-terminal domain-like; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 90..121
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 155..231
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT DOMAIN 1686..1801
FT /note="Tubby C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01167"
FT REGION 531..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 986..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1532..1673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 916..964
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 775..791
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1534..1561
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1567..1589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1590..1607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1638..1664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1807 AA; 200305 MW; 70EF405AD3FBCF22 CRC64;
MSRNYEPGQS VGMLAAVEHG PILCSDSNIL CLSWKGRVPK SEKDKPVCRR RYYEEGWLAT
GNGRGVVGVT FTSSHCRRDR STPQRINFNL RGHNSEVVLV RWNEPFQKLA TCDMEGGIFV
WIQYEGRWSV ELVNDRGAQV SDFTWSHDGT QALIAYRDGF VLVGSVSGQR HWSSEINLES
QITCGIWTPD DQQVLFGTAD GQVIVMDCHG RMLAHVLLHE SDGIVSMSWN CPDFLVEDST
ESDTDSDDNI LPLVRRVKPL LTVTFLSGDI SLMNNYDDLS PSIIRSGLKD VEAQWCSQGD
LLAVAGMERH GLPSDSACAS IMRNALVKFY NVQGEHIYTL ETPAQRPITT ICWGHRDSRL
FLACGPALYV VRVEHRVASL QLLCQQGIAS ALREEKDVGK LNMPSLLCSY VTTAFIPTIK
PPIPDPNNIR DFVSYPTAGN ERLHCTMKRA EDSPEAGGPC YTLYLEYLGG LVPILKGRRI
SKLRPEFVIM DPKTDGKAEE VCVNPMISYT DSCNCSDSSD IELSDEWVGK KSPKLSRGNR
LNMESRKSPK LSRANQEGQR SPRLPTKKPP VRSPSLTRRE FSMDGITEHN YLAQVTSNIW
GTKFKIVGLA SFLPTNLGAV IYKTSLLHLQ PRQMTIYLPE VRKISHDFMS LPVFNPNVFS
EDEDDLPVMG PSGVAGDNPP CTVNIPIAPI HSPAQAMSPT QSIGLVQSLL ANQNIQLDVL
TNPTATAAAA AAAAAASVPV TDHGQDAVAS PYPVPTRYTS PGQMIFNGLE MGPLLPGTLP
PPPPPHHLPP QPHSQRSHSQ QPRQQPSKQS QQIQTQQQQK MHHHQQQQGQ LQQQQHHHPS
QSQQQLQQQQ QLQQQQHQQL QQLHHQQGQQ QQQQHHHPSQ SQQLQQHQQL QQLHHQQTLH
QQQQHQQHQV QQHQQMQQAQ QQVTNQQLQQ QQIQQQQQQM QMQHEQMQQQ HQQMQQQLKI
QMSLPPPPSG YPTISLQQIH LLPQMPPPTT EPGLDRGDHG HTLKPSLPRT LPPSFNDTDG
SVEIQMRKIN PPPPYPGTVV SAAAASAAAP PQTLITNCDS PSILAPDPCL KKDEFLLHPV
TLQYPTPLGY ERITTFDSSG NVEEVCRPRR RLIRNQNAYA VHSIGGSATL KVTSSENKKI
QLPYSSATLS RLSVPRYTIP SGDPPPYPDP ANQVTATLPP PQRIDSSLIH ATLRRERRDV
GLKVPQMMDS SRTLPTKAKM NSALALSYQQ RVPTALYTCT QCSSNSSSTS VSVSGGGTTS
SGIAGGTVVR QDFPSGKGAH HSTIIVHSKN ASPMASQSSY SLLGGVDNSR DRTVYVNSAF
TEDETLNQQC HLEKSVRQLT LGDVSLTVKR PPPYQWDTSA TEDFWLTPDQ TMLAPPPHKP
PPLIISQAQH LDVTRLPFVL TTKPPTSPST STLTFPSGYQ ISLSPFPPGV GHSGPPLQTL
QNPPQQCSPN EVVAPVPFAQ QDPNLVLPPG YPPNLANLAC CPLPPLYPGA SSCAGLQLHP
VSLHPWNPYP CPPPMQDPPA PPLPTKTHQI LEKPILSPPP PTAPPPPPPL PPPPPPTELP
PSKSATEDLA ESANNFPEPS SLNESPVPQE SERFNKKSRK RLDSRAEEAN MPTVSEGKSR
KEGRALSDFN TLIASPRLGS REKKKPKGQR EQLNKTKKMN RTTNEFQDSS ESEPELFISG
DELMNQNQSS KKSWKNKRSM RMASELEEIK CRKANEREDR SLGSQGFVYV MANKQPLWNE
ATQVYQLDFG GRVTQESAKN FQIELDGRQV MQFGRIDGNA YILDFQYPFS AVQAFAVALA
NVTQRLK
//
