ID   A0A3Q2WTB6_HAPBU        Unreviewed;       785 AA.
AC   A0A3Q2WTB6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Amyloid beta A4 precursor protein-binding family A member 2-like {ECO:0000313|Ensembl:ENSHBUP00000029456.1};
GN   Name=APBA2 {ECO:0000313|Ensembl:ENSHBUP00000029456.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000029456.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000029456.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2WTB6; -.
DR   Ensembl; ENSHBUT00000019561.1; ENSHBUP00000029456.1; ENSHBUG00000013928.1.
DR   GeneTree; ENSGT00940000158943; -.
DR   Proteomes; UP000264840; Unplaced.
DR   CDD; cd00992; PDZ_signaling; 2.
DR   CDD; cd01208; PTB_X11; 1.
DR   Gene3D; 2.30.42.10; -; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   PANTHER; PTHR12345:SF12; AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2; 1.
DR   PANTHER; PTHR12345; SYNTENIN RELATED; 1.
DR   Pfam; PF00595; PDZ; 2.
DR   Pfam; PF00640; PID; 1.
DR   SMART; SM00228; PDZ; 2.
DR   SMART; SM00462; PTB; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50106; PDZ; 2.
DR   PROSITE; PS01179; PID; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          411..591
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   DOMAIN          604..689
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          695..771
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          1..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          194..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          277..390
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..88
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        96..120
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..145
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        196..220
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        277..293
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        311..326
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..354
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..389
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   785 AA;  86835 MW;  08915EF9FA5288D2 CRC64;
     MAAPGPASCP TTHATESCDL KAVAARQRPH RYPKESREPK PLPLPHSCKA QYSSPKSQDT
     GRSHPEADAD QEEEVKRYSN HEPDAELQDQ RPATPSTPEH NHDRDDPNQG DFHGGADSLD
     DDSSSDYINN TSDDDDYDDG LAEEDEGVTY YIRYCPEDDS YLEGMDCNNQ GDCNHSHSRG
     DCTSTMQLAV EGWTEEGEGQ EAESEDYCPN EDEEEEGEEE ERNGRAYTGD YYAPEDNGNS
     VRVSPYRSRK VLVVEGETGE EAEEDIDQIV AEIKMSMSMG SLSSGTDQSP EELAQDPAPS
     DYPHSKPDAA PYPPPHHRHD SRPKSLNLPS MHHNNPDLQR GHKTHPRSPD DRQRWPQEQV
     SNGAEQPRKQ QRSDLNVPLE NNNVPEPTKK VASFPSFVDV PGPCEPEDLI DGIIFAANYL
     GSTQLLSERN PSKNIRMMQA QEAVSRVKVL KNTHSYGDAQ TLTEVDLFIS TQRIKVLNAD
     SQETMMDNAL RTISYIADIG NIVVLMARRR MPRTASQDCI ETTPGAPEAK KQYKMICHVF
     ESEDAQLIAQ SIGQAFSVAY QEFLRANGIN PEDLSQKEYS DIINTQEMYN DDLIHFSNSE
     NCKELQLEKS KGEILGVVIV ESGWGSILPT VILANMMNGG PAARSGKLSI GDQIMSINNT
     SLVGLPLATC QGIIKGLKNQ VQVKMNIVSC PPVTTVLIKR PDLKYQLGFS VQNGIICSLM
     RGGIAERGGV RVGHRIIEIN GQSVVATAHE KIVQALSNSV GEIHMKTMPA AMFRLLTGQE
     TPMYI
//