ID A0A3Q2WUH2_HAPBU Unreviewed; 489 AA.
AC A0A3Q2WUH2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Ammonium transporter Rh type C 2-like {ECO:0000313|Ensembl:ENSHBUP00000030534.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000030534.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000030534.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an ammonia transporter. May play a role in the
CC elimination of ammonia in the gill. {ECO:0000256|ARBA:ARBA00025220}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000256|ARBA:ARBA00011036}.
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DR RefSeq; XP_005915259.1; XM_005915197.1.
DR AlphaFoldDB; A0A3Q2WUH2; -.
DR STRING; 8153.ENSHBUP00000030534; -.
DR Ensembl; ENSHBUT00000021645.1; ENSHBUP00000030534.1; ENSHBUG00000015655.1.
DR GeneID; 102310185; -.
DR CTD; 100038797; -.
DR GeneTree; ENSGT00950000182844; -.
DR OMA; WQIAMVI; -.
DR OrthoDB; 5483564at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR PANTHER; PTHR11730; AMMONIUM TRANSPORTER; 1.
DR PANTHER; PTHR11730:SF30; AMMONIUM TRANSPORTER RH TYPE C; 1.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
DR SUPFAM; SSF111352; Ammonium transporter; 1.
PE 3: Inferred from homology;
KW Ammonia transport {ECO:0000256|ARBA:ARBA00023177};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 22..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..451
FT /note="Ammonium transporter AmtB-like"
FT /evidence="ECO:0000259|Pfam:PF00909"
SQ SEQUENCE 489 AA; 53996 MW; 14FEADEA558324FA CRC64;
MGNCCERAGN FFGPQNNTYI RVSLPAVCFV WQIAMVILFG VFIRYDEESD EKGWHEFKKS
HNITSNIEND FYFRYPSFQD VHVMIFVGFG FLMTFLKRYS FGGVGFNFLI AAFGLQWALL
MQGWFHSLDP VTGKITIGIE SLINADFCCA GSLIAYGALL GKVSPVQLMI VTLFGVTLFA
VEEYIILDLL HCRDAGGSMV IHTFGGYYGL AISWVLYRPN LNLSKRLNGS VYHSDLFAMI
GSLFLWMFWP SFNSAITNHG AGQHRTVINT YLSLAACVLT TFAISSMGQK KGKLDMVHIQ
NASLAAGVAM GTSAEFMITP YGSIIVGFCC GIISTFGYLY VTPFLEKRLK LQDTCGIHNL
HAVPGMLGGF VGAVVAAAAT EEVYGKEGLV ETFGLSGKFE NRSMSTQGAY QAAGTCVAIA
FGLVGGVCVG FILRFPLWGD PADDFCFDDE AYWELPEDEE TIPPVLEYNN HMINKHQDTH
ESQFSLEES
//
