ID   A0A3Q2WUJ3_HAPBU        Unreviewed;       688 AA.
AC   A0A3Q2WUJ3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Protein Smaug homolog 1 {ECO:0000256|ARBA:ARBA00041183};
DE   AltName: Full=Sterile alpha motif domain-containing protein 4A {ECO:0000256|ARBA:ARBA00041298};
GN   Name=SAMD4A {ECO:0000313|Ensembl:ENSHBUP00000030559.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000030559.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000030559.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Synapse, synaptosome {ECO:0000256|ARBA:ARBA00034102}.
CC   -!- SIMILARITY: Belongs to the SMAUG family.
CC       {ECO:0000256|ARBA:ARBA00008232}.
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DR   AlphaFoldDB; A0A3Q2WUJ3; -.
DR   Ensembl; ENSHBUT00000033126.1; ENSHBUP00000030559.1; ENSHBUG00000015778.1.
DR   GeneTree; ENSGT00940000157933; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0030371; F:translation repressor activity; IEA:InterPro.
DR   GO; GO:0043488; P:regulation of mRNA stability; IEA:InterPro.
DR   CDD; cd09557; SAM_Smaug; 1.
DR   Gene3D; 1.25.40.170; Smaug, PHAT domain; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR037093; PHAT_dom_sf.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR037634; Smaug_SAM.
DR   PANTHER; PTHR12515:SF8; PROTEIN SMAUG HOMOLOG 1; 1.
DR   PANTHER; PTHR12515; STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Synapse {ECO:0000256|ARBA:ARBA00022599};
KW   Synaptosome {ECO:0000256|ARBA:ARBA00022599};
KW   Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT   DOMAIN          347..410
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|SMART:SM00454"
FT   REGION          154..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          257..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          458..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          608..688
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..292
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        619..633
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        645..688
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   688 AA;  74483 MW;  3EE7666B229BAA41 CRC64;
     MMFRDQVGVL ASWFKGWNEC EQTVALLSLL KRVSPTQARF LQLCLEHSLA ECTELQVLEG
     EANNPGIISQ WQSEPKERVI SLVLTHLPLL KPGNVEAKGE YMRLLPRILA HTIEHGHHLE
     ESRQLLSYAL IHPATSPEDR AALALWLNHL EERERDSLER PPPAGPHHHH QSTPPSTLTS
     SGSCSSTNTS SSGIPYLHHH QRYGSDDRLN GWQSSRDSGI GGGWHQHGCE NGHLPLYPSS
     SVPATINTVG IGGGSNAILT SGGGSQQHSP LKRSVSLTPP MSGPNNQPLG HAWLSQEDLR
     TARGPAPDHA PLSPQSSIAS SGSGGSEHLE DAGLGGGSGL HRSSFHEEGS GMRDVPAWLK
     SLRLHKYAAL FSTMTYDEMM ALTEEQLEAQ KVTKGARHKI VISIQKLKER QNLLRSLEKD
     VLEGGNLRAP LQELHQMIMT PIKAFSGGEE ASLHRPLLTP EGKSAAPGSH LSGGSGGEAE
     SGTSVIAEGG IPGQFTRVMG KVCTQLLVSR SDEDNISSYL QLIDKCLIHE SFTETQKKRL
     LSWKQQVQRL FRSIPRKNLL DIAGYRPQRS RFGQSNSLPT TGCVGGSVSA RRSLHQFQMP
     SRSLPGARLG LLGSGGLLGP TPRSSSSTPT GPKQGRHGPW FANPGGSNSM PSRTHSSVQR
     TRSLPVHTTP QTVVTFQQAD GADRTSTI
//