ID A0A3Q2WUQ6_HAPBU Unreviewed; 1434 AA.
AC A0A3Q2WUQ6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRU {ECO:0000313|Ensembl:ENSHBUP00000030042.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000030042.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000030042.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR Ensembl; ENSHBUT00000020597.1; ENSHBUP00000030042.1; ENSHBUG00000015066.1.
DR GeneTree; ENSGT00940000157151; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF10; PROTEIN-TYROSINE-PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1434
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018606453"
FT TRANSMEM 747..770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..183
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 282..377
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 380..482
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 488..588
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 901..1132
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1052..1123
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1164..1427
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1343..1418
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 824..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1434 AA; 161573 MW; BAB3E3D23D508860 CRC64;
HQNSQRTQLM RFSFFLPLAV AGCTFDEDSD PGLCEYRQGQ EDDFDWQLIR TYNWPHPTPD
LLRGSFMMVN SSQHYGGQRA QLLLLPLSEN DTHCIQFSYF LYSRDGHSPG DLQVYVRVNS
GPKGSAVWNI SGSQGRQWHQ VELAVSTFWP SEYQVIFEAT VSEERQGYIA LDDIVLLNYP
CYKVAHFSRL GDVEVNAGQN ASFQCVATGK VSEAEPFLLE RRNGVLLDTS MLTRLSHKRL
MATFQVEAQR GEQDLYRCIT LSPRGAAVSN FGELIVRVPP TPIAPPQLLR AGPTYLIIQL
NTNSIVGDGP VIRREIQYRA SQSTWTETHG VGSLTYKVWH LEPDTEYHIS VLLTRPGEGG
TGAPGPPLIS RTKCAEPMRA LRGLTATEIQ PRQLTLQWEP LGYNLTRCHT YTLSLCYRYS
MPTGGSGGNN ATVRECLSVD RNTSHFTLRD LPPFRAVHVR LALANPEGKK ESREVTFQTE
EDIPGGIAPE SLTFTPLDDM IFLKWEEPIE PNGLITQYEI SYQSIESSDP GINVPGPRRT
VSKLRNETYH MFSGLHPGTT YLVSVRARTA KGFGQTALTE ITTNISAPVF DYEDIPSPLS
ESESTITVLL RPALGRGAPV SAYQVVVVEE DGSRHVKRRE LGTVDCFPTP NSHNEAQAKG
APHYYTAELA PSSLPEATPF TVGDNHTYNG YWNSPLDPTK NYLIYFQATS NFRGETRINC
IRIARKAACK DSKRALEVSQ HAEDMGLILG ACAGGLVVLI LLLGAIVIIV KKGKKVAINK
AAMSYRQEKS RKLSSLDCSM TEQSTLQQDE RMAHSFMDAH GCNARNEQRS SVNESSSLLG
GSPQRHCRRK SSPYHTGQLH PAVRVADLLQ HINQMKTAEG YGFKQEYESF FDGWDVTKKK
DKTKGRHDSL LSHDRHRVKL HSLLADPSSD YVNANYIDGY QRSNHFIATQ GPKQEMIYDF
WRMVWQENCF SIVMITKLVE VGRMKCCKYW PDDTELYGDI KITLLKTETL AEYTVRTFAM
ERRGYPAKHE VCQFHFTSWP EHGVPYHATG LLAFLRRVKA STPPDAGPVV VHCSMGAGRT
GCYIVLDVML DMAECEGVVD IYNCVKTLCS RRINMIQTEE QYVFIHDAIL EACLCGETAI
PVTEFALTYK EMLKVDSQSN SSQLKEEFQT LNSVTPHLDV EECSISLMPR NREKNRSMDV
LPPDRSLAFL VTTEGESSNY INAALADSFL RPAAFVVTPH PLPGTTTDFW RLVYDYGCTS
VVMLNQLNQS NSAWPCLQYW PEPGLQQFGP MTVELLSRTA DDDVIIRLFR VQNITRLQEG
QLVVRHFQFL RWSPYRDVPD SKKAFLSLLA QVHNWQRECG EGRTIVHCLN GGGRSGTFCA
CTMILEMIRH HSIVDVFFAA KTLRNSKPNM VETMEQYRFC YDLAQEYLDC LEVR
//
