ID A0A3Q2WV61_HAPBU Unreviewed; 310 AA.
AC A0A3Q2WV61;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Fucolectin-1-like {ECO:0000313|Ensembl:ENSHBUP00000030804.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000030804.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000030804.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a defensive agent. Recognizes blood group fucosylated
CC oligosaccharides including A, B, H and Lewis B-type antigens. Does not
CC recognize Lewis A antigen and has low affinity for monovalent haptens.
CC {ECO:0000256|ARBA:ARBA00002219}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SIMILARITY: Belongs to the fucolectin family.
CC {ECO:0000256|ARBA:ARBA00010147}.
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DR RefSeq; XP_005929499.1; XM_005929437.2.
DR AlphaFoldDB; A0A3Q2WV61; -.
DR STRING; 8153.ENSHBUP00000030804; -.
DR Ensembl; ENSHBUT00000022172.1; ENSHBUP00000030804.1; ENSHBUG00000016062.1.
DR GeneID; 102306104; -.
DR GeneTree; ENSGT01060000248575; -.
DR OMA; FTCNGMD; -.
DR OrthoDB; 5306009at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0042806; F:fucose binding; IEA:UniProt.
DR GO; GO:0010185; P:regulation of cellular defense response; IEA:UniProt.
DR GO; GO:0001868; P:regulation of complement activation, lectin pathway; IEA:UniProt.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR006585; FTP1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR45713; FTP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45713:SF8; V-FBPL-RELATED; 1.
DR Pfam; PF00754; F5_F8_type_C; 2.
DR SMART; SM00607; FTP; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR PROSITE; PS50022; FA58C_3; 1.
PE 3: Inferred from homology;
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..310
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018692651"
FT DOMAIN 156..307
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
SQ SEQUENCE 310 AA; 33925 MW; 11936FD89CC6177E CRC64;
MKTSVFLLLL LLRTSSTSTY QNVALRGTAA QSISEDHVLS AAHNAIDGNR NSDFRAGSCT
LTSAQNRPWW RVDLLQSYII TSVTITNRGD CCHERLNGLK IHIGNSLNNE GLGNPKVGEI
SEVGAGISFS VTFTDRAEGR YVILTLPGSR KILTLCEVEV YGYRSPTGDN LALEGKATQS
SLYGFGFAYN AIDGNRNSKW EEGSCTHTNN NISPWWRLNL RKTHKVFSVK IVNIDSNPER
LNGAEIRIGD SLDNNGNNNP RCAVITNIAG GAVANFTCNG MDGRYVNIVI PAREEFLSLC
EVEVYGSKLD
//
