ID   A0A3Q2WW04_HAPBU        Unreviewed;      1509 AA.
AC   A0A3Q2WW04;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=IQ motif containing GTPase activating protein 2 {ECO:0000313|Ensembl:ENSHBUP00000026549.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000026549.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000026549.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   STRING; 8153.ENSHBUP00000026549; -.
DR   Ensembl; ENSHBUT00000003192.1; ENSHBUP00000026549.1; ENSHBUG00000009270.1.
DR   GeneTree; ENSGT00950000183076; -.
DR   OMA; CANKYYD; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR   GO; GO:0003094; P:glomerular filtration; IEA:Ensembl.
DR   GO; GO:0072015; P:podocyte development; IEA:Ensembl.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 1.20.5.190; -; 2.
DR   Gene3D; 2.20.70.10; -; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000593; RasGAP_C.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001202; WW_dom.
DR   PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR   PANTHER; PTHR14149:SF12; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00612; IQ; 3.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF03836; RasGAP_C; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00015; IQ; 4.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF143885; RGC domain-like; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS50096; IQ; 4.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT   DOMAIN          41..157
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          531..558
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   DOMAIN          849..1082
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          262..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          779..803
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          171..198
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        266..284
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1509 AA;  173708 MW;  B0076FFEFD0734A4 CRC64;
     MYHEETAALH RPRYGTIQDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW MEACLEEDLP
     PTTELEERLR NGVYLGKLAN FFAPKMVSEK RIYDRDQSRY KSKGLHFRHT DNTVQWLRAM
     ESVGLPKFYF HGMIYSVLYR FFFAQLLHRM CLCLFFFSSL YLYKLGIAPQ IQDLLGKVDF
     TEEEISNMRS ELEKYGIQMP AFSKIGGILA NELSIDEAAL HAAVIAINEA VDRGQASVTM
     GALNNPNAML RNTQEPLAQE YQDTLSQTKS RKRDQSSGRR SSVAAEERDV YEELLNQQEI
     QTCIDLVNSK SFPMFALHTF SLKHCHVSQM FLSLCEMVIM YLRIQTISGY ISPPFLRYSD
     MLIKERAEAL STGQEFLTWN DVQKCIDTVN VQVQEEHERI IAIAEINEAL NSGDHEQTLA
     ALLLPTAKLS GVNPATAKHY HDVLQNTKQL LCQSSGDESA VLWLDQIQEA ILTANQDEKE
     ALTVNEGDSQ NTLEALQAPS VGLRAVLPEC ADTYQDDLSQ KQRDCSTDGV WVKHCIKDKY
     DYFYNLETEQ GTWEEPEGFE QNSGHLSKEE IQNVVTCVTA EYNREQLWLA NECFMTKLQA
     RVRGYLVRKR HVQRMEYLHQ QEPHVIKLQA CWKGYKQRKV YKERMTLLQK NVASIVKIQS
     FVKMWKAKRE YNQRQQFFKD HEKEIVKIQA FLKANKARED YRTLTGAKDP PLSVVRKFVH
     LLEQSPLDLQ EEQEVTRLRE EVVTKIRSNQ QMEKDLNLMD IKIGLLVKNR ITLQDVVSHN
     KKMKSKKNKA SKEDPTAGDR LGIKGLSKGK RRKLEAYQHL FYLLQTNPSY LAKLIFQMPQ
     NKSTKFMDTV IFTLYNYASN QREEYLLLKL FKTALEEEIN SKVDQIQDIV TGNPTVIKMV
     VSFNRGARGH NTLRQLLAPV IKDIIEDKSL GLNTNPVEVY KAWVNQLESA TGEASKLPYE
     VTPEQAMSHE EVRNRLQASS QTLRSATDKV LNSIVSSLDN LPYGMRYIAK VLKNSLHEKF
     PDASEDELLK IVGNLLYYRY MNPAIVAPDG FDIIDLSAGG QLHQDQRRNL GSVAKMLQHA
     AAKNLFEGEN AHMTPMNNYI SQTYEKFRLF FQSACDVPEP EEKFNIDEYS DMVNLSKPII
     YISIEEIINT HSLLLEHLDA ISPERNDLLH ELLQDLGDVP DVEALLGEGA VDPNDQNRES
     ALSQLAKTEI SLTLTSKFEL LEGDDRDLKT LSTKTKKLIV DVIRIQHGET LPEILETPAT
     AAQESEHTRI VERRAVQDAQ TPEGLKSSPA LLEDSQLPLE QKKRKIIRNL RNLEQAGLAT
     ASNKYQDLIN EISKDIRYQR RYRQRRKAEL VKLQQTLTAL NSKTAFYQEQ MNYYDAYIKT
     CLDNLNRKNS RRSIKLDGKG EDKGSKKWKP QSLKYTAAKL HEKGVILEIE GLQTNQFKNV
     MFDISPTEEV GDFEVKAKFM GVEMEKVQLH FQDLLQLQYE GVAVMKMFDK AKVNVNLLIF
     LLNKKFYGK
//