ID A0A3Q2WWU1_HAPBU Unreviewed; 731 AA.
AC A0A3Q2WWU1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial {ECO:0000256|ARBA:ARBA00013888};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000030451.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000030451.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the complex I 75 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00005404, ECO:0000256|RuleBase:RU004523}.
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DR RefSeq; XP_005948784.1; XM_005948722.1.
DR AlphaFoldDB; A0A3Q2WWU1; -.
DR STRING; 8153.ENSHBUP00000030451; -.
DR Ensembl; ENSHBUT00000021490.1; ENSHBUP00000030451.1; ENSHBUG00000015547.1.
DR GeneID; 102311881; -.
DR GeneTree; ENSGT00940000153514; -.
DR OMA; TMTACNT; -.
DR OrthoDB; 19999at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR CDD; cd00207; fer2; 1.
DR CDD; cd02773; MopB_Res-Cmplx1_Nad11; 1.
DR Gene3D; 3.10.20.740; -; 1.
DR Gene3D; 3.30.200.210; -; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR000283; NADH_UbQ_OxRdtase_75kDa_su_CS.
DR InterPro; IPR010228; NADH_UbQ_OxRdtase_Gsu.
DR InterPro; IPR019574; NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
DR InterPro; IPR015405; NDUFS1-like_C.
DR NCBIfam; TIGR01973; NuoG; 1.
DR PANTHER; PTHR43105:SF13; NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF13510; Fer2_4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF10588; NADH-G_4Fe-4S_3; 1.
DR Pfam; PF09326; NADH_dhqG_C; 1.
DR SMART; SM00929; NADH-G_4Fe-4S_3; 1.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS51839; 4FE4S_HC3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00641; COMPLEX1_75K_1; 1.
DR PROSITE; PS00642; COMPLEX1_75K_2; 1.
DR PROSITE; PS00643; COMPLEX1_75K_3; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Translocase {ECO:0000256|ARBA:ARBA00022967}.
FT DOMAIN 34..112
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
FT DOMAIN 112..151
FT /note="4Fe-4S His(Cys)3-ligated-type"
FT /evidence="ECO:0000259|PROSITE:PS51839"
FT DOMAIN 249..305
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 731 AA; 79133 MW; 2D8BE0F2BA7E24EA CRC64;
MLRLPTVGRA LAGAAKGSLA SSNPVRTPVR AASNMVEVFV DGKPVEVEPG TTVLQACEKV
GVQIPRFCYH ERLSVAGNCR MCLVEIEKAP KPVAACAMPV MKGWNILTNS EKTQKAREGV
MEFLLANHPL DCPICDQGGE CDLQDQSMQF GSDRSRFSEG KRAVEDKNIG PLIKTIMTRC
IQCTRCVRFA SEIAGVEDLG TTGRGNDLQI GTYVEKMFMS ELSGNVIDIC PVGALTSKPY
AFTARPWETR KTESIDVLDA VGSNIVVSTR GGEVMRILPR LHDDINEEWI SDKTRFAYDG
LKRQRLTQPM VKDESGQLTP TTWEDALTRV AGALQSVQGS EVAAIVGGMA DAEALVALKD
LLNRLNSENL CTEELFPMAG AGTDLRSNYL LNSRIAGIED CDLLLLVGTN PRYEAPLFNA
RIRKSWLHNE LQIATVGHKV DLSYTYDHLG EDTSVLKQLA NGTHAFCKVL SAAKRPVVVV
GSGALQREDG VAILSAVSTI AQNARASSGV EGSWKVLNVL HRVASQVAAL DLGYKAGVDA
IRKNPPKVLF LLGADAGCIS RADLPKDSLI IYQGHHGDVG APMADIILPS AAYTEKNGTY
VNTEGRSQHT KIAVTAPGVA REDWKIIRAL SELTGVTLPY DSLDEIRSRL AEVSPNLVRY
DDVEEANYFK QANELAMTVN QELLAAPLVP PQLTVKDFYM TDSISRASQT MAKCVKAVTE
GAAAVDEPSV C
//
