ID A0A3Q2WXI0_HAPBU Unreviewed; 689 AA.
AC A0A3Q2WXI0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Neurexin-2-like {ECO:0000313|Ensembl:ENSHBUP00000027129.1};
GN Name=NRXN2 {ECO:0000313|Ensembl:ENSHBUP00000027129.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000027129.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000027129.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR RefSeq; XP_014192050.1; XM_014336564.1.
DR AlphaFoldDB; A0A3Q2WXI0; -.
DR Ensembl; ENSHBUT00000001595.1; ENSHBUP00000027129.1; ENSHBUG00000010203.1.
DR GeneID; 102303057; -.
DR CTD; 560420; -.
DR GeneTree; ENSGT00940000155978; -.
DR OrthoDB; 2999458at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR InterPro; IPR027789; Syndecan/Neurexin_dom.
DR PANTHER; PTHR15036:SF52; NEUREXIN-2; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF01034; Syndecan; 1.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 614..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 114..314
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 486..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..595
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 689 AA; 74873 MW; 1C609CA0E95CC9D8 CRC64;
MFTSCVCRMR GRGLTILSGP TPMEQEVEVE VDGGLLMVSR PSAASPVVWA SPAFLFRLVL
SLALLVFPCP AVAARVSSSL STTHHVHHFH NKHGTVPIAI NRMPFLTRGG HAGTTYIFGR
GGALITYTWP PNDRPSTRAD RLAVGFSTQL KEAVLVRVES ARGLGDYLEL HIERGKVGVI
FNVGTDDITI EESAVMVSDG KYHVVRFTRS GGNATLQVDN QPVIERFPSG NFDNERLAIA
RQRIPYRLGR VVDEWLLDKG RQLTIFNSQA FIKIGGGEKG RHFQGQISGL YYNGLQVLKL
AAEGDPNVQT QGNLRLVGDV PSVLTTDTTS TTPLADMSTT IMETTTTMAT TTTRKQRSPT
MRDSVTQNSD DLLVASAECP SDDEDLEECE PGNGGELVLP IITVDSLDPP SIATHYPVIP
PPPTTYRPFL TLLETTKESL PLPNGRPPCP LDQEDCEETI EVSAYGSGEM TESDDEDYYK
NSALVTDRTV LPPPPAVEGG VQNPRDRHFS RFPNSRPPLS STPTANPDQL NPRIKSAGGG
SSSSSNNIPA GKMNTRDQVL LPPAQPSLDP GHRRVPGITY PPNFPHVPTP DPTSPERGLP
GAVEVQQSSS TTGMVVGIVA AAALCILILL YAMYKYRNRD EGSYQVDQSR NYISNSATQS
NGALVKEKQP STAKTVTKNK KNKDKEYYV
//
