ID   A0A3Q2WZ41_HAPBU        Unreviewed;       538 AA.
AC   A0A3Q2WZ41;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Solute carrier family 40 member {ECO:0000256|RuleBase:RU365065};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000032389.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000032389.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC       {ECO:0000256|RuleBase:RU365065}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU365065}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365065}.
CC   -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC       subfamily. {ECO:0000256|ARBA:ARBA00006279,
CC       ECO:0000256|RuleBase:RU365065}.
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DR   AlphaFoldDB; A0A3Q2WZ41; -.
DR   STRING; 8153.ENSHBUP00000032389; -.
DR   Ensembl; ENSHBUT00000034324.1; ENSHBUP00000032389.1; ENSHBUG00000018677.1.
DR   GeneTree; ENSGT00940000164650; -.
DR   OMA; YPVFISY; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   CDD; cd17480; MFS_SLC40A1_like; 1.
DR   InterPro; IPR009716; Ferroportin-1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR   PANTHER; PTHR11660:SF50; SOLUTE CARRIER FAMILY 40 PROTEIN; 1.
DR   Pfam; PF06963; FPN1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Ion transport {ECO:0000256|RuleBase:RU365065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365065};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365065};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365065};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365065}.
FT   TRANSMEM        27..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        60..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        95..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        167..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        279..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        311..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        436..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        475..499
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        505..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
SQ   SEQUENCE   538 AA;  59388 MW;  F1351E98CEE2B112 CRC64;
     GALSMWGDRM WHFAISVFLI ELYGRNLLLT AVFGLVVAGS VLMFGALIGD WVDRNPRNKV
     AHASLFVQNI SVTICSIVLM LVFSYKQRIE QIWDGWLTVV CYTVVIVLAD VANLASTALT
     IAIQRDWIVV ITGYNRGHLA GMNATMRRID QVTNILAPLA VGQVMTLASN VVGCGFILGW
     NLVSLIVEFF FLSRVYRIVP ALSAKPPSVA VDQAYLQRIE RKRLQGEGNV ARPQALTEGN
     CNSSLHLKEI TDLPLCFRRF RWLVSTCKDG WMAYYRQPVF LAGMGLAFLY TTVLGFDCIT
     TGYAYTQGIS GSLLSLLMGV SAITGLMGTI MFTRLRKAYG LVNTGIISSC LHLGCLLLCV
     CSVFAPGSPM DLSLLMPDIS SNSSTALGGM TGQRQKHTYP MMGGSNQPLL PDRSSIHWTN
     NTVLFDNVPS GTAPESYISI ILLFLGVITA RIGLWSFDLT VTQLLQENIC ESERGVVNGV
     QSSMNYLMDL LHFIMVISAP QPQHFGILVI ISVFFITTGH TMYFLYAHKA KRKRRLDT
//