ID   A0A3Q2X332_HAPBU        Unreviewed;       852 AA.
AC   A0A3Q2X332;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Splicing factor Cactin {ECO:0000256|ARBA:ARBA00034534};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000033969.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000033969.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CACTIN family.
CC       {ECO:0000256|ARBA:ARBA00006895}.
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DR   RefSeq; XP_005920599.1; XM_005920537.2.
DR   AlphaFoldDB; A0A3Q2X332; -.
DR   STRING; 8153.ENSHBUP00000033969; -.
DR   Ensembl; ENSHBUT00000028287.1; ENSHBUP00000033969.1; ENSHBUG00000021214.1.
DR   GeneID; 102312894; -.
DR   CTD; 58509; -.
DR   GeneTree; ENSGT00950000183102; -.
DR   OMA; HIDFWND; -.
DR   OrthoDB; 558574at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0008595; P:anterior/posterior axis specification, embryo; IEA:Ensembl.
DR   GO; GO:0003407; P:neural retina development; IEA:Ensembl.
DR   GO; GO:0040019; P:positive regulation of embryonic development; IEA:Ensembl.
DR   InterPro; IPR019134; Cactin_C.
DR   InterPro; IPR018816; Cactin_central.
DR   PANTHER; PTHR21737:SF6; CACTIN; 1.
DR   PANTHER; PTHR21737; POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3; 1.
DR   Pfam; PF10312; Cactin_mid; 1.
DR   Pfam; PF09732; CactinC_cactus; 1.
DR   SMART; SM01050; CactinC_cactus; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT   DOMAIN          359..546
FT                   /note="Splicing factor cactin central"
FT                   /evidence="ECO:0000259|Pfam:PF10312"
FT   DOMAIN          728..852
FT                   /note="Splicing factor Cactin C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF09732"
FT   REGION          1..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          566..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          315..360
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..19
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..56
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        78..93
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..215
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..273
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        570..599
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        613..627
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   852 AA;  100036 MW;  FCC3E3A6ED49D803 CRC64;
     MSSKSRRRAR SKSRSRSRDR PNKSRGNKSR SPDERRDHSR SADGKTAARG RGRSFSRDSS
     DGSPAQRRPQ HRGRSGSSSG SESDRRRETQ SQMNRSKGRS SSPDSDNTKM RRRRKEQESH
     RTTSRERRKG RSQSSSDSHD GSGDRERRRR RSPERGSPSR DRQRREWDRE KERHKNSGRD
     GDKSRERRKK SEDRERGRSN RSQEKSDRGR GKQRFSSSES SESSESDCER GALKEKEERN
     KQKEMMKALE TPEEKRARRL AKKEAKEKKR REKMGWSEEY LGYTNADNPF GDNNLLGTFK
     WQKALDKKGI GHLGEKELKE RNKCIQEENR RELQKVKQLR LEREREKAMR EQELEMLQRE
     KEAEYFKTWA EQEDNFHLHQ AKLRSKIRIR DGRAKPIDLL AKYISAEDDD LAVEMHEPYT
     FLNGLTVTDM DDLLEDIKVY MELEQGKNVD FWRDMTTITE DEISKLRKLE ASGKGPGDRR
     EGINTAVSTD VQSVFKGKTY SQLQALHQNI EAKIRAGGSN LDIGYWESLL QQVKVYMARA
     RLRERHQEVL RQKLFKLKQE QGVESEPLFP IIKEEPRSEE DDERGGQTRE KKRNTETEPE
     EGPSTSTAGN QDEEGGEKGD KKDGEEKDEV VEAVLTEEDL IQQSQAEYDS GRYSPTLLMQ
     SELPLDTHTI TPEEDAHRLQ LARRQLQVTG DASESAEDAF VRRAKEGMGN DEAQFSVEFP
     VTGKMYLWAD KYRPRKPRFF NRVHTGFEWN KYNQTHYDFD NPPPKIVQGY KFNIFYPDLI
     DKRSTPQYFL EPSPDNKDFG ILRFHAGPPY EDIAFKIVNR EWEYSHRHGF RCQFANGIFQ
     LWFHFKRYRY RR
//