ID A0A3Q2X3U0_HAPBU Unreviewed; 1116 AA.
AC A0A3Q2X3U0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000034279.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000034279.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280815}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q2X3U0; -.
DR Ensembl; ENSHBUT00000028915.1; ENSHBUP00000034279.1; ENSHBUG00000021769.1.
DR GeneTree; ENSGT00940000166212; -.
DR OMA; ITGDCNE; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF29; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 10.
DR Pfam; PF12661; hEGF; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 14.
DR SMART; SM00214; VWC; 1.
DR SMART; SM00215; VWC_out; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 10.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 11.
DR PROSITE; PS50026; EGF_3; 15.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 960..984
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..120
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 121..154
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 187..225
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 227..263
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 265..301
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 303..339
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 341..376
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 378..414
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 416..452
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 482..518
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 520..556
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 558..594
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 596..632
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 635..671
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 673..709
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 711..747
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1079..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 78..87
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 91..103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 111..120
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 144..153
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 215..224
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 253..262
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 291..300
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 329..338
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 345..355
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 366..375
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 404..413
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 442..451
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 508..517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 546..555
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 584..593
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 622..631
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 661..670
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 699..708
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 737..746
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1116 AA; 122288 MW; 0B640ED62273581F CRC64;
MMQELLLSTN APCMSCLPQR SYTLIVEALD FNNETSGVDG RLIEKASHSG MINPSPQWQK
LTHNGPVAQF EYQIRVSCDE HYYGFGCNKF CRPRDEFFGH YTCDNNGNKT CLEGWSGPDC
NTAICRQGCS TEHGSCKEPG GCKCLYGWQG QYCDKCIPHP GCVHGTCKEP WQCLCDINWG
GHLCDKDLNY CGTHQPCLNR GTCINTGPDK YQCTCAEGYS GANCERAEHA CLSNPCSNGG
SCSETSQGFE CQCAPGWTGP SCTINVDDCL PNPCNHGGTC QDLVNSYKCH CPSQWTGKTC
LIDANECDSK PCVNANSCRN LIGGYFCECL PGWTGQNCDI NINDCKDQCQ NGGTCKDLVN
GYRCACPPGF AGEHCERDID ECASSPCLNG GRCQDEVNGF QCLCLTGFSG NLCQLDIDYC
LPNPCQNGAV CFNLATDYYC ACPEDYEGKN CSHLKDHCRT TTCKVIDSCT VAVASNSTPG
GERYISSNVC GPHGRCQSQA GGQFSCECQE GFRGTYCHEN INDCESNPCR NGGTCIDKVS
VYQCICGDGW EGDHCEINID DCSTNPCHNG GTCRDLVTDF FCECKNGWKG KTCHSRESQC
DEATCNNGGT CYDEGDTFQC KCSPGWEGTT CNIAKNSSCL PNPCENGGTC VVTGDSFTCV
CKEGWEGPTC TQNTNDCSPH PCYNSGTCVD GDNWYRCECA PGFAGPDCRI NINECQSSPC
ALGSTCVDEI NGYRCLCPPD RTGSHCQEVT RKPCSVNGHV TPDGVKWDED CNTCHCSNGK
VVCTKMWCGP MSCKLGAKGR GECPSGQSCI PLREGHCFVK PCIELGECWH SDPPQPPTKC
HPSSTYQDNS CANITFTFNK EIMPRVQGLT VEGVCKQLRS LYVVKNFSLE HSVSITCDPS
FSASNEIHVC ISTDDHRLDG SPVKKITERI IDLVSKHNGN NTIISAIAEV RVPSPSKTDY
LVPLLSSIFI VIWVLVLVSI LLWCMRRRRK QSNHNGTSAT SSEDNTTNNV REQLNQIKNP
IEKHVGLTVA IKDYENKNSI IAKIRTNHPE GDEDDKERHL QKGRFAKQPA YTLVERDEKA
TISNPNSTSK HANWTNKQDN RDLETANSIN RMDYIV
//
