ID A0A3Q2X3Y3_HAPBU Unreviewed; 485 AA.
AC A0A3Q2X3Y3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Transcription factor E3-like {ECO:0000313|Ensembl:ENSHBUP00000033381.1};
GN Name=TFE3 {ECO:0000313|Ensembl:ENSHBUP00000033381.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000033381.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000033381.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
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DR AlphaFoldDB; A0A3Q2X3Y3; -.
DR Ensembl; ENSHBUT00000027145.1; ENSHBUP00000033381.1; ENSHBUG00000020599.1.
DR GeneTree; ENSGT00940000157503; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR PANTHER; PTHR45776:SF3; TRANSCRIPTION FACTOR E3; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 269..322
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 118..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 315..356
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 118..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 53582 MW; FD758ECCD4904A55 CRC64;
LHHLLIMITK VCCHFCLQFI SSSSLLFIFF TAVSDVIEDL MRQQALEEEH KETQKKQQQL
LRFSDSSSPI CVSVPSSCIP PAQVPVEVLK VQTHLENPTR YHIQQAQRQQ VRQYLSTTKT
ANQQQAAVAS HSPQLGSTPG QPMDGSPKQE VRNKHVNKQT DIIVDDIISL DSSLNDEFLT
LIDSELQLAN TLPDPENLLD GYGGSVGNTM PTLTVSNSCP ANLHAVKREL TGKYHTLRLH
VTRYHRLSMK DDGQLGFVDS AFCALASSRW VAIFLEPERR RRFNINDRIK ELGALIPKSS
DPLTRWNKGT ILKASVDYIR KLQKEQHRAR EMEERQRRLE STNHSLMLRI QELELQARVH
GLSSSSSNSP PPKSSSSSLD PQTLLSPPLL HPFSSSSSPP SSSSLVTPSL GLDALTFTDL
DEPQGAATVF SPDLMSDMGL TDLNGLGGLL MEDGSGAGVM SDPLLSCGAS KTSSRRSSFS
MDEDL
//
