UniProt: A0A3Q2X645

Database: UniProt
Entry: A0A3Q2X645_HAPBU

LinkDB:  A0A3Q2X645_HAPBU 
Original site:  A0A3Q2X645_HAPBU

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Ontology (7)   
   GO (7)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein domain (29)   
   InterPro (17)   
   Pfam (6)   
   PROSITE (3)   
   SMART (3)   
All databases (39)   

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ID   A0A3Q2X645_HAPBU        Unreviewed;      2502 AA.
AC   A0A3Q2X645;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Talin-2 {ECO:0000313|Ensembl:ENSHBUP00000034717.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000034717.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000034717.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   Ensembl; ENSHBUT00000029769.1; ENSHBUP00000034717.1; ENSHBUG00000022692.1.
DR   GeneTree; ENSGT00940000154699; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0005925; C:focal adhesion; IEA:InterPro.
DR   GO; GO:0001726; C:ruffle; IEA:InterPro.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd10569; FERM_C_Talin; 1.
DR   CDD; cd17172; FERM_F0_TLN2; 1.
DR   CDD; cd17174; FERM_F1_TLN2; 1.
DR   CDD; cd12150; talin-RS; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 5.
DR   Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.20.1420.10; Talin, central domain; 8.
DR   InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR032425; FERM_f0.
DR   InterPro; IPR035964; I/LWEQ_dom_sf.
DR   InterPro; IPR002558; ILWEQ_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR037438; Talin1/2-RS.
DR   InterPro; IPR015224; Talin_cent.
DR   InterPro; IPR036476; Talin_cent_sf.
DR   InterPro; IPR049108; Talin_R4.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR015009; Vinculin-bd_dom.
DR   PANTHER; PTHR19981; TALIN; 1.
DR   PANTHER; PTHR19981:SF34; TALIN-2; 1.
DR   Pfam; PF16511; FERM_f0; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF01608; I_LWEQ; 1.
DR   Pfam; PF09141; Talin_middle; 1.
DR   Pfam; PF21692; Talin_R4; 1.
DR   Pfam; PF08913; VBS; 1.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00307; ILWEQ; 1.
DR   SMART; SM01244; IRS; 1.
DR   SUPFAM; SSF109880; A middle domain of Talin 1; 1.
DR   SUPFAM; SSF47220; alpha-catenin/vinculin-like; 6.
DR   SUPFAM; SSF109885; I/LWEQ domain; 4.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS00661; FERM_2; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS50945; I_LWEQ; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840}.
FT   DOMAIN          88..406
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   DOMAIN          2254..2493
FT                   /note="I/LWEQ"
FT                   /evidence="ECO:0000259|PROSITE:PS50945"
FT   COILED          906..933
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1052..1079
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2461..2488
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   2502 AA;  267692 MW;  2D8025E51DF3FD44 CRC64;
     MVALSLKICV RQCNVVKTMQ FEPSTAVYDA CRIIRERVPE AQTGQASDYG LFLSDEDPRK
     GIWLESGRTL DYYMLRNGDI LEYKKKQRPQ KIKMLDGAVK TIMVDDSKTV GELLVTICSR
     IGITNYEEYS LIQETVEEKK EDGMGTLKKD RTLLRDERKM EKLKAKLHTD DDLNWLDHSR
     TFREQGVDEN ETLLLRRKFF YSDQNVDSRD PVQLNLLYVQ ARDDILNGSH PVSFDKACEF
     GGIQAQIQFG PHIEHKHKPG FLDLKEFLPK EYIKQRGAEK KIFQEHKNCG EMTEIEAKVK
     YVKLARSLRT YGVSFFLVKE KMKSKNKLVP RLLGITKESV MRVDEKTKDV VQEWPLTTVK
     RWAASPKSFT LDFGEYQESY YSVQTTEGEQ ISQLIAGYID IILKKKQSKD RFGLEGDEES
     TMLEESVSPK KSTILQQQFN RMGRVEHGSV ALPGVIRSGS IGAESLSMGT MPSPQQQITM
     GQMHRGHMPP LSSAQQALMG TINTSMQAVQ KAQIDLGEVD NLPPLGQDMA SKVWIQNKMD
     ESKHEIHSQV DAITAGTASV VNLTAADPTD TDYTAVGCAI TTISSNLTEM SKGVKLLAAL
     MEDDVGGGND LMKAARTLAG AVSDLLKAVE PASGEPRQTV LTAAGSIGQA SGDLLRQIGE
     NETDERFQDV LMNLAKAVAN AAAMLVLKAK NVAQVAEDTV LQNRVIAAAT QCALSTSQLV
     ACAKVVSPTI SSPVCQEQLI EAGKLVDRSV ESCVQACLSA TEDGELLKQV SAAASVVSQA
     LGDLLQHVRQ YTSRGEPIGR YDQATDTIMT VTESIFSSMG DAGEMVRQAR VLAQATSDLV
     NAMRSDAEAE VDVDNSKKLL AAAKLLADAT ARMVEAAKGA AAYPENEDQQ QRLREAAEGL
     RVATNAAAQN AIKKKLINRL ENAAKQAAAA ATQTIAAAQN AAASNKNTAA HQQLVQSCKA
     VADHIPQLVQ GVRGSQAKPE DLSAQLALII ASQNFLQPGS KMVTSAKSSV PTVTDQAAAM
     QLGQCAKNLA TCLAELRTSA QKAHEACGPM EIDSALTAIQ TLRSELQDAK MTAVNAQLKP
     LPGESLEKCA QDLGSTSKSV GSSMAQLLTC AAQGNEHYTG IAARETAQAL KTLAQAARGV
     AASTTEPKGA AAMLDSARDV MEGSALLIHE AKQALISPGD AESQQRLAQV AKAVSHSLNN
     CVNCLPGQKD VDMALKSIGE ASKKLLIETI PPASKSFQEA QSELNQTAAE LNQSAGEVVH
     ASRGSSSQLA VASGKFSQDF DEFLDAGIEM AGHTQKKDDQ VQVIGNLKNI SMASSKLLLA
     AKSLSVDPAA ANAKNLLAAA ARAVTDSINQ LITLCTQQAP GQKECDNALR ELEAVRGMLD
     NPNEPVSDLS YFDCIESVME NSKVLGESMA GISQNCKTGD VSAFGDCVGS ASKALCGLTE
     AAGQASYLVG VSDPNSQAGH QGLVDPIQFA KANQAIQMAC QNLVDPESSP SQVLSAATIV
     AKHTSALCNA CRLASSKTTN PVAKRHFVQS AKEVANSTAN LVKTIKALDG DFSEENRNRC
     RVATAPLIEA VENLTTFASN PEFASVPAKI SSEGSAAQEP ILQSARSMLD SSTHLLKTAR
     SLVINPKDPP TWSVLAGHSR TVSDSIKSLI TAIRDKAPGQ RECDSSIDNI NKCIRDIEQA
     SLAAVSQNLP SRDDISLEAL QEQLTSTVQE IGHLIDPVST AARGEASQLG HKVTQLAGYF
     EPLIKASVGV ASKLKDHQQQ MTFLDQTKTL AESALQMLYA AKEGGGNRKA SHTHDAIAEA
     AQLMKEAVDD IMVTLNEAAS EVGMVGGMVE SIADAMAKLD EGTPPEPEGS FVDYQTSMVK
     YSKAIAVTAQ EMIGFQIKTR VQDLGHGCIF LVQKAGALQI TPSDSFTKRE LIDCARAVTE
     KVSLVLSALQ AGNKGTQACI TAATAVSGII ADLDTTIMFA SAGTLNAENE ESFADHRENI
     LKTAKALVED TKMLVSGAAS GQEKLAQAAQ SSAKTITQLT DVVKLGAASI GSDDPETQVV
     LINAVKDVAK ALGELISATK CAAGKAADDP SMYQLKSAAK VMVTNVTSLL KTVKAVEDEA
     TRGTRALEAT IECIKQEMSV FQSRDAPNKT TTPEEFIRMT KGITMATAKA VAAGNSGRQE
     DIIHTANVSR KAMSDMLTTC KQAAYHPEVS EEVKNRALMF GAECTTAYID LLEHVLLVLQ
     KPTAEQKQHL AACSKRVAGA VTELIQTAEA MKGSEWVDPE DPTVIAETEL LGAAASIEAA
     AKKLEQLKPR AKPKQADETL NFEEQILEAA KSIAAATSAL VKSASAAQRE LVAQGKVGSV
     PANAVDDGQW SQGLISAARM VAAATSNLCE AANASVQGHA SEEKLISSAK QVAASTAQLL
     VACKVKADQD SEAMRRLQIA GNAVKKASDN LVRAAQKAAF EKSDEDNVVV KTKFVGGIAQ
     IIAAQEEMLR KERELEEARK KLAQIRQQQY KFLPSELRED SN
//

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