ID   A0A3Q2X994_HAPBU        Unreviewed;      1242 AA.
AC   A0A3Q2X994;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Ski2 like RNA helicase {ECO:0000313|Ensembl:ENSHBUP00000035506.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000035506.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000035506.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_005936320.1; XM_005936258.2.
DR   AlphaFoldDB; A0A3Q2X994; -.
DR   STRING; 8153.ENSHBUP00000035506; -.
DR   Ensembl; ENSHBUT00000031250.1; ENSHBUP00000035506.1; ENSHBUG00000000726.1.
DR   GeneID; 102313688; -.
DR   CTD; 6499; -.
DR   GeneTree; ENSGT00940000158255; -.
DR   OMA; CGSDITR; -.
DR   OrthoDB; 1352at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR   CDD; cd18027; DEXHc_SKIV2L; 1.
DR   CDD; cd18795; SF2_C_Ski2; 1.
DR   Gene3D; 1.10.3380.30; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR048392; MTR4-like_stalk.
DR   InterPro; IPR025696; MTR4_beta-barrel.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016438; SKI2-like.
DR   InterPro; IPR012961; Ski2/MTR4_C.
DR   InterPro; IPR040801; Ski2_N.
DR   PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR   PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08148; DSHCT; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF21408; MTR4-like_stalk; 1.
DR   Pfam; PF13234; MTR4_beta-barrel; 1.
DR   Pfam; PF17911; Ski2_N; 1.
DR   PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01142; DSHCT; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          323..479
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          594..759
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          137..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..248
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        265..283
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1242 AA;  138813 MW;  5F8B18E287E03DDA CRC64;
     MDRLNVPPPG PMDLPMSLLE MGCSGRFELI THPVPGQSLP PHSTLPHGLP PTNLNLETEV
     EKQFLRDPAW LPIHDKDFAF QKFLKVTQRK VDVDSLLNCC PSPLHSGLSV VRDPTTGMLL
     DFTEVLLENT GLSAKNSLSL QRQPGPPSES LRGSNTNYPF LPGGMEELTL EQIKKKSELE
     EEIDFESALL KVAPGLKAGM DFTDKDAKIA KPEVNLMSLL STVEGISGLQ LEEKEKDKES
     EDAPKLPRTN SLEDLGIKDA ASSSSPPEKG KEEKSKLKEN TEENKKWAIP VNITSPCDDF
     HKRIPNPAFK WPFELDVFQK QAVLRLEAHD SVFVAAHTSA GKTVVAEYAI ALSQKHMTRT
     IYTSPIKALS NQKFRDFKNT FGDVGLLTGD VQLSPESSCL IMTTEILRSM LYNGSEVIRD
     LEWVIFDEVH YINDAERGVV WEEVLIMLPD HVSIILLSAT VPNALEFSEW IGRIKKRHIY
     VISTLKRPVP LEHYLYTGNS TKTQKEMFLL VDATGNFLTK GYYAAVDAKK ERTSKHAQSF
     GTKNTSQNTT ASQDRSVWLT LLHFLSQRQQ TPVVAFTFSR TRCDENARSL DSMDLTTSIE
     KAEIHSFFQK SLTRLRGADR QLPQILLMRD LLKRGIAVHH SGILPILKEV IEMLFSRGLV
     KVLFATETFA MGVNMPARTV VFDSIRKHDG TGFRNLLPGE YIQMAGRAGR RGLDATGTVI
     ILCKAGVHEM ADLHVMMLGK PTLLQSQFRL TYTMILNLLR VEALRVTDMM RRSFSESHRD
     TQTHEKRISQ LKQMLSAVPS VDTEGQLSDL LPYYHTVTEL KKTTEAVQHA ILESVNGLKA
     LSVGRVIVVN NKQHLNALGV ILQVSSASVN RTFTALIICE KGNEEGKGND NAALPHLHNT
     SLFIPEGPCS HTVQKLKLQD ISAITVKTLK VIPERIIDNY NKRQQPRFKL DPPGQAISTA
     TQELLRLAEA NPGGIATLDP VNDLQLKSVD VVEANMRLRV LQDSLRDFNC IHSPMFAEQF
     ARIKERMSLQ EELDQLLFLV SDQSLTLLPE YHQRIKVLQS LQYIDSGGAV QLKGRVACQI
     SSHELLLTEL LFENVLSPLA PEESAALLSC LVFTQNTQVE PHITNTLQEG IEQVKSVAQR
     IGELQRECGI PQTAEEFVGQ FKFGLTEVVY CWARGMPFAE IAQLTDVQEG TVVRCIQRLD
     EVLKEVRQAA RIVGDSVLGS KMEKASLAIR RDIVFTASLY TH
//